MedPath

Sulfadoxine

Generic Name
Sulfadoxine
Drug Type
Small Molecule
Chemical Formula
C12H14N4O4S
CAS Number
2447-57-6
Unique Ingredient Identifier
88463U4SM5
Background

A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.

Indication

Sulfadoxine is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well.

Sulfadoxine and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.

Associated Conditions
Malaria, Malaria caused by Plasmodium falciparum, Acute, uncomplicated Malaria caused by plasmodium falciparum
Clinical Trials
Related News

Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children

Not Applicable
Conditions
Seasonal Malaria Chemoprevention
Mass Drug Administration With Anthelminthic Drugs
Soil Transmitted Helminths
Schistosomiasis
Malaria
Integrated Control
Interventions
First Posted Date
2022-04-29
Last Posted Date
2022-07-14
Lead Sponsor
London School of Hygiene and Tropical Medicine
Target Recruit Count
600
Registration Number
NCT05354258
Locations
🇸🇳

Saraya Health Centre, Saraya, Kedougou, Senegal

Effectiveness and Chemoprevention Efficacy of Implementing Seasonal Malaria Chemoprevention in Karamoja Region, Uganda

Phase 4
Active, not recruiting
Conditions
Malaria
Interventions
First Posted Date
2022-04-12
Last Posted Date
2023-11-01
Lead Sponsor
Malaria Consortium
Target Recruit Count
6805
Registration Number
NCT05323721
Locations
🇺🇬

Amudat, Amudat, Karamoja, Uganda

Comparison of ISTp- PYRAMAX-US-RDT to IPTp-SP to Prevent Malaria in Pregnant Women in DRC (ULTRAPYRAPREG)

Phase 3
Completed
Conditions
Malaria in Pregnancy
Interventions
First Posted Date
2021-03-04
Last Posted Date
2022-11-04
Lead Sponsor
University of Kinshasa
Target Recruit Count
250
Registration Number
NCT04783051
Locations
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Maternité Esengo, Kinshasa, Congo, The Democratic Republic of the

Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin

Phase 3
Active, not recruiting
Conditions
Malaria,Falciparum
Interventions
First Posted Date
2019-11-04
Last Posted Date
2023-03-07
Lead Sponsor
University Clinical Research Center, Mali
Target Recruit Count
4556
Registration Number
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Locations
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Ucrc - Usttb, Bamako, Select, Mali

Azithromycin (AZ) and Sulphadoxine-pyrimethamine (SP) for Malaria Prevention in Pregnant Women (IPT-AZ/IPT-SP)

Not Applicable
Conditions
Malaria in Pregnancy
Pregnancy
Interventions
First Posted Date
2019-05-09
Last Posted Date
2019-05-10
Lead Sponsor
Federal Medical Centre, Owo
Target Recruit Count
168
Registration Number
NCT03944317
Locations
🇳🇬

FMCOWO, Owo, Ondo, Nigeria

Controlled Human Malaria Infection Model for Evaluation of Transmission-blocking Interventions - Study 2

Not Applicable
Completed
Conditions
Malaria,Falciparum
Controlled Human Malaria Infection
Transmission
Gametocytes
Interventions
Other: malaria challenge infection, P. falciparum 3D7
Other: Blood stage malaria challenge infection, P. falciparum 3D7
First Posted Date
2018-03-05
Last Posted Date
2020-07-07
Lead Sponsor
Radboud University Medical Center
Target Recruit Count
24
Registration Number
NCT03454048
Locations
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Radboud university medical center, Nijmegen, Gelderland, Netherlands

Intermittent Preventive Treatment in Infant in Mali

Not Applicable
Completed
Conditions
Malaria
First Posted Date
2008-10-06
Last Posted Date
2008-10-06
Lead Sponsor
University of Bamako
Registration Number
NCT00766662
Locations
🇲🇱

Malaria Research & Training Center; Faculty of Medicine, Pharmacy and Dentistry, University of Bamako, Bamako, Mali

Antimalarial Treatments for Clearing Low Density P. Falciparum and Its Impact on Malaria Transmission

Phase 3
Completed
Conditions
Plasmodium Falciparum
Asymptomatic Parataemia
Sub Patent Parasitaemia
Interventions
Drug: placebo tablet similar to active drug in shape and size
First Posted Date
2008-03-28
Last Posted Date
2008-03-28
Lead Sponsor
Tropical Medicine Research Institute
Registration Number
NCT00646126
Locations
🇸🇩

Tropical Medicine Research Institute, Khartoum, Sudan

Three Alternative Drug Regimens for Malaria Seasonal Preventive Treatment in Senegal

First Posted Date
2007-09-14
Last Posted Date
2010-05-27
Lead Sponsor
London School of Hygiene and Tropical Medicine
Target Recruit Count
1833
Registration Number
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Locations
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Departement de Parasitologie et Mycologie, Universite Cheikh Anta Diop, Dakar, Senegal

Efficacy of Sulfadoxine-Pyrimethamine for Treating Malaria in Gabonese Children

Phase 4
Terminated
Conditions
Malaria
First Posted Date
2007-03-29
Last Posted Date
2007-08-10
Lead Sponsor
Albert Schweitzer Hospital
Target Recruit Count
139
Registration Number
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Locations
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Medical Research Unit of the Albert Schweitzer Hospital, Lambaréné, Moyen Ogooué, Gabon

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