Amodiaquine

Generic Name: Amodiaquine

Brand Names: -

Drug Type: Small Molecule

Chemical Formula: C_₂₀H_₂₂ClN_₃O

CAS Number: 86-42-0

Unique Ingredient Identifier: 220236ED28

Background: A 4-aminoquinoquinoline compound with anti-inflammatory properties.

Indication: For treatment of acute malarial attacks in non-immune subjects.

Associated Conditions: -

Associated Therapies: -

Clinical Trials

Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali

Phase 2

Completed

Conditions: Malaria,Falciparum

Interventions: Drug: Artemether-lumefantrine
Drug: Artesunate-amodiaquine combination
Drug: Amodiaquine
Drug: Primaquine Phosphate

First Posted Date: 2022-09-22

Last Posted Date: 2024-09-30

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 100

Registration Number: NCT05550909

Locations: 🇲🇱
Malaria Research and Training Centre, Bamako, Mali

Chemoprevention Efficacy Study in Burkina Faso

Phase 4

Active, not recruiting

Conditions: Malaria

Interventions: Drug: Sulfadoxine pyrimethamine
Drug: Amodiaquine

First Posted Date: 2022-07-28

Last Posted Date: 2023-11-01

Lead Sponsor: Malaria Consortium

Target Recruit Count: 800

Registration Number: NCT05478954

Locations: 🇧🇫
Unité de Recherche Clinique de Nanoro, Nanoro, Burkina Faso

Effectiveness, Feasibility and Acceptability of Seasonal Malaria Chemoprevention in Aweil South County in South Sudan

Phase 3

Active, not recruiting

Conditions: Malaria

Interventions: Drug: Sulfadoxine pyrimethamine
Drug: Amodiaquine

First Posted Date: 2022-07-25

Last Posted Date: 2024-03-25

Lead Sponsor: Malaria Consortium

Target Recruit Count: 3575

Registration Number: NCT05471544

Locations: 🇸🇸
Aweil South, Aweil, Northern Bahr El Gazal, South Sudan

Feasibility and Safety of Combining Anti-malarial With Deworming Drugs in African Children

Not Applicable

Conditions: Seasonal Malaria Chemoprevention
Mass Drug Administration With Anthelminthic Drugs
Soil Transmitted Helminths
Schistosomiasis
Malaria
Integrated Control

Interventions: Drug: Praziquantel
Drug: Albendazole
Drug: Sulfadoxine pyrimethamine
Drug: Amodiaquine

First Posted Date: 2022-04-29

Last Posted Date: 2022-07-14

Lead Sponsor: London School of Hygiene and Tropical Medicine

Target Recruit Count: 600

Registration Number: NCT05354258

Locations: 🇸🇳
Saraya Health Centre, Saraya, Kedougou, Senegal

Pharmacokinetic Study of Artemether-lumefantrine and Amodiaquine in Healthy Subjects

Phase 1

Recruiting

Conditions: Pharmacokinetic
Healthy
Drug Combination

Interventions: Drug: Amodiaquine
Drug: Artemether-lumefantrine
Drug: Artemether-lumefantrine + Amodiaquine

First Posted Date: 2019-09-06

Last Posted Date: 2024-03-08

Lead Sponsor: University of Oxford

Target Recruit Count: 16

Registration Number: NCT04080895

Locations: 🇹🇭
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Phase 2 Efficacy Study of Primaquine and Methylene Blue

Phase 2

Completed

Conditions: Malaria

Interventions: Drug: Sulphadoxine-pyrimethamine
Drug: Dihydroartemisinin-piperaquine
Drug: Methylene blue
Drug: 0.25 mg/kg primaquine
Drug: Amodiaquine

First Posted Date: 2016-07-13

Last Posted Date: 2017-01-11

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 80

Registration Number: NCT02831023

Locations: 🇲🇱
Malaria Research and Training Centre, Bamako, Mali

Study of Artemether-lumefantrine, Amodiaquine and Primaquine in Healthy Subjects

Phase 1

Terminated

Conditions: Drug Combination
Healthy
Pharmacokinetic

Interventions: Drug: Artemether-lumefantrine
Drug: Amodiaquine
Drug: Artemether-lumefantrine + Amodiaquine
Drug: Primaquine
Drug: Artemether-lumefantrine + Amodiaquine + Primaquine
Drug: Artemether-lumefantrine + Primaquine

First Posted Date: 2016-03-02

Last Posted Date: 2019-06-28

Lead Sponsor: University of Oxford

Target Recruit Count: 17

Registration Number: NCT02696954

Locations: 🇹🇭
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

Evaluation of Oral Activated Charcoal on Antimalarial Drug's Ability to Kill Parasites in Malian Children With Malaria

Phase 2

Completed

Conditions: Malaria
Severe Malaria

Interventions: Drug: Actidose Aqua
Drug: Artesunate
Drug: Amodiaquine

First Posted Date: 2013-10-07

Last Posted Date: 2018-02-06

Lead Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Target Recruit Count: 70

Registration Number: NCT01955382

Locations: 🇲🇱
Universite des Sciencies, Techniques et Technologies de Bamako, Bamako, Mali

A Comparative Safety and Activity Study With Ferroquine Associated With Artesunate Versus Amodiaquine Associated With Artesunate in African Adult Patients With Uncomplicated Malaria

Phase 1

Completed

Conditions: Malaria

Interventions: Drug: ferroquine (SSR97193)
Drug: amodiaquine

First Posted Date: 2007-11-26

Last Posted Date: 2009-12-21

Lead Sponsor: Sanofi

Target Recruit Count: 72

Registration Number: NCT00563914

Locations: 🇰🇪
Sanofi-Aventis Administrative Office, Nairobi, Kenya

Arsucam® (Artesunate + Amiodaquine) Efficacy and TOLerance

Phase 4

Completed

Conditions: Malaria

First Posted Date: 2007-03-09

Last Posted Date: 2008-04-10

Lead Sponsor: Sanofi

Target Recruit Count: 300

Registration Number: NCT00445796

Locations: 🇸🇳
Sanofi-Aventis, Dakar, Senegal

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