Overview
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Indication
For nutritional supplementation, also for treating dietary shortage or imbalance
Associated Conditions
- Hangover
- Nerve Disorders
- Neuropathy
Research Report
Glutathione (DB00143): A Comprehensive Monograph on its Biochemistry, Pharmacology, and Clinical Utility
Executive Summary & Introduction
Overview
Glutathione (GSH), a tripeptide molecule identified by DrugBank ID DB00143 and CAS Number 70-18-8, is the most abundant and significant non-protein thiol synthesized within mammalian cells.[1] Composed of the amino acids L-glutamate, L-cysteine, and glycine, it represents a cornerstone of cellular defense and metabolic homeostasis.[1] Its ubiquitous presence across nearly all tissues and in various cellular compartments underscores its fundamental role in maintaining life and cellular integrity.[4] This monograph provides an exhaustive, evidence-based analysis of Glutathione, intended for a professional audience of clinicians, researchers, and pharmacists. It aims to synthesize the vast body of knowledge spanning its fundamental biochemistry, complex pharmacology, investigated clinical applications, and critical safety considerations.
Core Physiological Importance
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2025/04/10 | Not Applicable | Recruiting | General Hospital of Shenyang Military Region | ||
2025/03/26 | Phase 1 | Recruiting | The First Affiliated Hospital of Zhengzhou University | ||
2023/07/20 | Phase 4 | Terminated | |||
2019/09/26 | Phase 1 | Completed | Dr Irma Bernadette S Sitohang | ||
2017/01/13 | Phase 2 | Completed | |||
2016/07/28 | Phase 1 | UNKNOWN | South Florida Veterans Affairs Foundation for Research and Education | ||
2015/10/22 | Phase 3 | Completed | Robert J. Porte | ||
2015/04/23 | Phase 2 | Completed | |||
2014/12/24 | Phase 1 | Completed | |||
2014/12/09 | Phase 3 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Guangzhou Kadiya Biotechnology Co., Ltd. | 84423-084 | CUTANEOUS | 5 mg in 250 mg | 7/31/2025 | |
| The Wellness Center for Research and Education, Inc. | 50181-0031 | ORAL | 6 [hp_X] in 1 mL | 5/28/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Orthoplex Clinical C | 299281 | Medicine | A | 2/2/2018 | |
| Entity RadianiX | 379157 | Medicine | A | 11/26/2021 | |
| Aurinda White Tomato Skin Booster | 422210 | Medicine | A | 9/21/2023 | |
| L-Glutathione Tablets | 420814 | Medicine | A | 9/1/2023 | |
| Princess Luna Liver Detox Max Plus | 448830 | Medicine | A | 5/16/2024 | |
| Poem Care EGT | 485205 | Medicine | A | 4/4/2025 | |
| METAGENICS GLUTATHIONE CAPSULES 250mg | 233639 | Medicine | A | 2/11/2015 | |
| Bioglan Medlab Manuka-C | 391036 | Medicine | A | 6/21/2022 | |
| Liposomal Glutathione | 320160 | Medicine | A | 7/15/2019 | |
| Henry Blooms Liposomal Glutathione Sublingual Tablet | 445559 | Medicine | A | 4/9/2024 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| ESSENTIALS PLUS - TAB | alive international | 02229851 | Tablet - Oral | 0.5 MG | 1/28/1997 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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