Cidofovir
- Generic Name
- Cidofovir
- Brand Names
- Vistide
- Drug Type
- Small Molecule
- Chemical Formula
- C8H14N3O6P
- CAS Number
- 113852-37-2
- Unique Ingredient Identifier
- 768M1V522C
- Background
Cidofovir is an injectable antiviral medication employed in the treatment of cytomegalovirus (CMV) retinitis in patients diagnosed with AIDS. It suppresses CMV replication through selective inhibition of viral DNA synthesis. It was manufactured by Gilead and initially approved by the FDA in 1996, but has since been discontinued.
- Indication
用于治疗免疫功能缺陷患者不能耐受更昔洛韦和膦甲酸钠治疗或治疗无效的巨细胞病毒感染。
- Associated Conditions
- Cytomegalovirus Retinitis, Herpes Simplex Virus, Monkeypox, Variola Major (Smallpox)
- Associated Therapies
- -
Use of Cidofovir for Recurrent Respiratory Papillomatosis
- Conditions
- Interventions
- First Posted Date
- 2005-09-20
- Last Posted Date
- 2019-02-26
- Lead Sponsor
- University of Wisconsin, Madison
- Target Recruit Count
- 19
- Registration Number
- NCT00205374
Cidofovir in Renal Transplant Recipients With BKVN
- First Posted Date
- 2005-08-30
- Last Posted Date
- 2013-03-08
- Target Recruit Count
- 22
- Registration Number
- NCT00138424
- Locations
- 🇺🇸
Dartmouth-Hitchcock Medical Center - Infectious Disease, Lebanon, New Hampshire, United States
🇺🇸California Pacific Medical Center - Sutter Pacific Medical Foundation - Transplant Nephrology, San Francisco, California, United States
🇺🇸Mayo Clinic, Rochester - Infectious Diseases, Rochester, Minnesota, United States
Antiviral Therapy in Treating Patients With Kaposi's Sarcoma With or Without HIV Infection
- Conditions
- First Posted Date
- 2004-04-21
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- National Cancer Institute (NCI)
- Registration Number
- NCT00019240
- Locations
- 🇺🇸
Medicine Branch, Bethesda, Maryland, United States
A Phase I/II Study of the Safety and Efficacy of Topical 1-(S)-(3-Hydroxy-2-Phosphonylmethoxypropyl)Cytosine Dihydrate (Cidofovir; HPMPC) in the Treatment of Refractory Mucocutaneous Herpes Simplex Disease in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 30
- Registration Number
- NCT00002116
- Locations
- 🇺🇸
Mount Zion Med Ctr / UCSF, San Francisco, California, United States
🇺🇸Los Angeles County - USC Med Ctr, Los Angeles, California, United States
🇺🇸Johns Hopkins Hosp, Baltimore, Maryland, United States
An Open-Label Study of the Safety and Efficacy of Cidofovir for the Treatment of Relapsing Cytomegalovirus Retinitis in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 100
- Registration Number
- NCT00002142
- Locations
- 🇺🇸
Besselaar Associates, Princeton, New Jersey, United States
The Safety and Effectiveness of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 48
- Registration Number
- NCT00002437
- Locations
- 🇬🇧
Charing Cross and Westminster Med School, London SW 10, United Kingdom
🇺🇸Mount Zion Med Ctr, San Francisco, California, United States
🇺🇸Univ of North Carolina Hosps, Chapel Hill, North Carolina, United States
A Study of Cidofovir in the Treatment of Cytomegalovirus (CMV) of the Eyes in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Registration Number
- NCT00002384
The Safety and Effectiveness of Cidofovir in the Treatment of Venereal Warts in HIV-Infected Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Gilead Sciences
- Target Recruit Count
- 40
- Registration Number
- NCT00002327
- Locations
- 🇺🇸
Dr Brad Bowden, Houston, Texas, United States
🇺🇸Pacific Med Ctr, Seattle, Washington, United States
🇺🇸Houston Clinical Research Network, Houston, Texas, United States
HPMPC (Cidofovir) Peripheral CMV Retinitis Trial Protocol
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2012-11-01
- Target Recruit Count
- 100
- Registration Number
- NCT00000799
- Locations
- 🇺🇸
Johns Hopkins Hosp / SOCA, Baltimore, Maryland, United States
🇺🇸UCSD - Shiley Eye Ctr / SOCA, La Jolla, California, United States
🇺🇸UCLA - Jules Stein Eye Institute / SOCA, Los Angeles, California, United States
Treatment With Cidofovir for Children With Laryngeal Papillomatosis (Warts in the Throat)
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2010-08-27
- Target Recruit Count
- 36
- Registration Number
- NCT00001126
- Locations
- 🇺🇸
NIAID/DMID/CASG Central Unit, Birmingham, Alabama, United States
Drug Development Updates
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