Hydroxychloroquine
- Generic Name
- Hydroxychloroquine
- Brand Names
- Plaquenil, Sovuna
- Drug Type
- Small Molecule
- Chemical Formula
- C18H26ClN3O
- CAS Number
- 118-42-3
- Unique Ingredient Identifier
- 4QWG6N8QKH
- Background
Hydroxychloroquine is a racemic mixture consisting of an R and S enantiomer. Hydroxychloroquine is an aminoquinoline like chloroquine. It is a commonly prescribed medication in the treatment of uncomplicated malaria, rheumatoid arthritis, chronic discoid lupus erythematosus, and systemic lupus erythematosus. Hydroxychloroquine is also used for the prophylaxi...
- Indication
Hydroxychloroquine is indicated for the prophylaxis of malaria where chloroquine resistance is not reported, treatment of uncomplicated malaria (caused by P. falciparum, P. malariae, P. ovale, or P. vivax), chronic discoid lupus erythematosus, systemic lupus erythematosus, acute rheumatoid arthritis, and chronic rheumatoid arthritis.
- Associated Conditions
- Acute Rheumatoid Arthritis, Malaria, Porphyria Cutanea Tarda, Q Fever, Sjogren's Syndrome (SS), Systemic Lupus Erythematosus, Uncomplicated Malaria caused by Plasmodium Vivax, Uncomplicated Malaria caused by Plasmodium malariae, Uncomplicated Malaria caused by Plasmodium ovale, Chronic Discoid Lupus Erythematosus (DLE), Chronic Rheumatoid Arthritis, Uncomplicated Malaria caused by Plasmodium falciparum
- Associated Therapies
- -
Hydroxychloroquine, Radiation, and Temozolomide Treating Patients With Newly Diagnosed Glioblastoma Multiforme
- Conditions
- Interventions
- First Posted Date
- 2007-06-14
- Last Posted Date
- 2019-07-10
- Target Recruit Count
- 92
- Registration Number
- NCT00486603
- Locations
- 🇺🇸
Winship Cancer Institute of Emory University, Atlanta, Georgia, United States
🇺🇸Case Comprehensive Cancer Center, Cleveland, Ohio, United States
🇺🇸Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, United States
Rheumatoid Arthritis: Comparison of Active Therapies in Patients With Active Disease Despite Methotrexate Therapy
- Conditions
- Interventions
- First Posted Date
- 2006-11-30
- Last Posted Date
- 2013-12-03
- Lead Sponsor
- US Department of Veterans Affairs
- Target Recruit Count
- 353
- Registration Number
- NCT00405275
- Locations
- 🇺🇸
VA Medical Center, Loma Linda, Loma Linda, California, United States
🇺🇸VA Pittsburgh Health Care System, Pittsburgh, Pennsylvania, United States
🇺🇸Geisinger Medical Group - State College, State College, Pennsylvania, United States
Hydroxychloroquine in Cystic Fibrosis
- Conditions
- First Posted Date
- 2006-04-06
- Last Posted Date
- 2008-01-30
- Lead Sponsor
- Vanderbilt University
- Target Recruit Count
- 20
- Registration Number
- NCT00311883
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Treatment of Early Aggressive Rheumatoid Arthritis (TEAR)
- Conditions
- Interventions
- First Posted Date
- 2005-11-29
- Last Posted Date
- 2014-07-17
- Lead Sponsor
- University of Alabama at Birmingham
- Target Recruit Count
- 755
- Registration Number
- NCT00259610
- Locations
- 🇺🇸
University of Alabama at Birmingham, Birmingham, Alabama, United States
Plaquenil for Alopecia Areata, Alopecia Totalis
- Conditions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2009-08-13
- Lead Sponsor
- Hordinsky, Maria K., MD
- Target Recruit Count
- 16
- Registration Number
- NCT00176982
- Locations
- 🇺🇸
State University of New York at Stony Brook, Stonybrook, New York, United States
🇺🇸University of Minnesota, Minneapolis, Minnesota, United States
Hydroxychloroquine vs. Clobetasol Rinse to Treat Oral Lichen Planus
- Conditions
- First Posted Date
- 2005-01-31
- Last Posted Date
- 2008-03-04
- Target Recruit Count
- 74
- Registration Number
- NCT00102557
- Locations
- 🇺🇸
National Institute of Dental And Craniofacial Research (NIDCR), Bethesda, Maryland, United States
Hydroxychloroquine in Treating Patients With Newly Diagnosed Chronic Graft-Versus-Host Disease
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2014-02-14
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 82
- Registration Number
- NCT00031824
- Locations
- 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
🇺🇸All Children's Hospital, St. Petersburg, Florida, United States
🇺🇸Maine Children's Cancer Program, Scarborough, Maine, United States
Drug Development Updates
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