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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Non-Narcotic Pain Control After ACL Reconstruction

Phase 3
Recruiting
Conditions
ACL - Anterior Cruciate Ligament Rupture
ACL Injuries
Interventions
Drug: dispense of study drug
First Posted Date
2025-05-15
Last Posted Date
2025-05-15
Lead Sponsor
The Cleveland Clinic
Target Recruit Count
30
Registration Number
NCT06973785
Locations
🇺🇸

Cleveland Clinic Coral Springs, Coral Springs, Florida, United States

🇺🇸

Cleveland clinic sports medicine, Garfield, Ohio, United States

🇺🇸

Cleveland Clinic, Strongsville, Ohio, United States

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection

Phase 3
Not yet recruiting
Conditions
Aortic Dissection
Inflammation
Interventions
Drug: 0.9 % saline
First Posted Date
2025-05-13
Last Posted Date
2025-05-13
Lead Sponsor
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Target Recruit Count
360
Registration Number
NCT06968806
Locations
🇨🇳

Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China

Oral Ketorolac for IUD Pain Reduction

Phase 2
Not yet recruiting
Conditions
IUD Insertion Pain
Interventions
Drug: Placebo
First Posted Date
2025-02-28
Last Posted Date
2025-02-28
Lead Sponsor
University of North Carolina, Chapel Hill
Target Recruit Count
108
Registration Number
NCT06853327
Locations
🇺🇸

University of North Carolina - Hillsborough Campus, Hillsborough, North Carolina, United States

Ketorolac at Lower Doses for Analgesic Pain Control in ICU: A Pilot Feasibility Study

Phase 3
Not yet recruiting
Conditions
Pain Management
Interventions
Drug: Placebo
First Posted Date
2025-02-11
Last Posted Date
2025-03-06
Lead Sponsor
University of Alberta
Target Recruit Count
30
Registration Number
NCT06819956
Locations
🇨🇦

University of Alberta Hospital, Edmonton, Alberta, Canada

Prophylactic Intravenous Injection of Neostigmine Plus Atropine Versus Ketorolac on Post-dural Puncture Headache in Patients Undergoing Infraumbilical Surgeries

Phase 1
Not yet recruiting
Conditions
Post-Dural Puncture Headache
Interventions
First Posted Date
2024-12-11
Last Posted Date
2024-12-11
Lead Sponsor
Assiut University
Target Recruit Count
330
Registration Number
NCT06729047
Locations
🇪🇬

Faculty of medicine, Assiut University, Assiut, Egypt,, Assiut, Egypt

Study of Complication Rates in Cataract Surgery Patients Treated With Combined Pre-operative NSAID, OMIDRIA, and Subconjunctival Triamcinolone Acetonide Compared With Peri-operative SOC

First Posted Date
2024-11-08
Last Posted Date
2024-11-28
Lead Sponsor
Inder Paul Singh, M.D.
Target Recruit Count
94
Registration Number
NCT06681688
Locations
🇺🇸

The Eye Associates - Venice, Venice, Florida, United States

🇺🇸

The Eye Centers of Racine & Kenosha, Racine, Wisconsin, United States

Combined Ketorolac and Lidocaine Paracervical Block for Office Hysteroscopy

Phase 1
Recruiting
Conditions
Abnormal Uterine Bleeding
Analgesia
Paracervical Block
Interventions
Procedure: paracervical block
First Posted Date
2024-10-22
Last Posted Date
2024-10-22
Lead Sponsor
Icahn School of Medicine at Mount Sinai
Target Recruit Count
44
Registration Number
NCT06653400
Locations
🇺🇸

Mount Sinai, New York, New York, United States

The Effect of Anti-inflammatory Cryoagent on the Level of Postoperative Pain in Patients with Symptomatic Irreversible Pulpitis and Apical Periodontitis.

Phase 2
Not yet recruiting
Conditions
Postoperative Pain
Interventions
First Posted Date
2024-09-04
Last Posted Date
2024-09-04
Lead Sponsor
Ain Shams University
Target Recruit Count
60
Registration Number
NCT06584188
Locations
🇪🇬

Faculty of Dentistry, Ain Shams University, Cairo, Egypt

Ketorolac for Acute Vaso-Occlusive Crisis in Pediatric Sickle Cell Disease

Phase 4
Not yet recruiting
Conditions
Sickle Cell Disease
Sickle Cell Crisis
Veno-occlusive Disease
Interventions
First Posted Date
2024-08-30
Last Posted Date
2024-08-30
Lead Sponsor
Children's Blood and Cancer Center at Dell Children's Medical Center
Target Recruit Count
102
Registration Number
NCT06579703

Ketorolac Effects on Post-operative Pain and Lumbar Fusion

Phase 4
Not yet recruiting
Conditions
Spinal Fusion
Interventions
First Posted Date
2024-07-22
Last Posted Date
2024-07-22
Lead Sponsor
University of Maryland St. Joseph Medical Center
Target Recruit Count
140
Registration Number
NCT06513208
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