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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain
Associated Therapies
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A Single-dose Study of Intranasal Ketorolac in the Treatment of Pain Secondary to Dental Impaction Surgery

Phase 2
Completed
Conditions
Dental Impaction
Pain
Interventions
First Posted Date
2011-05-19
Last Posted Date
2017-02-09
Lead Sponsor
Egalet Ltd
Target Recruit Count
80
Registration Number
NCT01356225
Locations
🇺🇸

Austin Oral Surgery - PPD Development, Austin, Texas, United States

Tolerability, Safety and Pharmacokinetics of Four Formulations of Ketorolac Tromethamine in Healthy Volunteers

Phase 1
Completed
Conditions
Healthy Volunteers
Interventions
First Posted Date
2011-05-18
Last Posted Date
2017-03-16
Lead Sponsor
Egalet Ltd
Target Recruit Count
16
Registration Number
NCT01355588
Locations
🇬🇧

Medeval Ltd, Manchester, United Kingdom

Study of the Safety, Tolerability and Analgesic Efficacy of Multiple Doses of Ketorolac Tromethamine (IN) for Postoperative Pain

Phase 2
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2011-05-10
Last Posted Date
2012-10-18
Lead Sponsor
American Regent, Inc.
Target Recruit Count
127
Registration Number
NCT01351090
Locations
🇳🇿

Waikato Clinical Research, Hamilton, New Zealand

Safety and Efficacy of Multiple Doses of Ketorolac Tromethamine Administered Intranasally for Postoperative Pain

Phase 3
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2011-05-04
Last Posted Date
2017-02-08
Lead Sponsor
Egalet Ltd
Target Recruit Count
300
Registration Number
NCT01347853
Locations
🇳🇿

Waikato Clinical Research, Hamilton, New Zealand

Use of Local Infiltration Analgesia Following Total Hip Arthroplasty

Phase 4
Completed
Conditions
Pain, Postoperative
Pain
Interventions
First Posted Date
2011-04-29
Last Posted Date
2013-01-23
Lead Sponsor
University of Aarhus
Target Recruit Count
80
Registration Number
NCT01344395
Locations
🇩🇰

Aarhus University Hospital, Aarhus, Denmark

Disposition of Intravenous Ketorolac

Phase 4
Completed
Conditions
Postoperative Pain
Interventions
First Posted Date
2011-02-08
Last Posted Date
2011-12-13
Lead Sponsor
Universitaire Ziekenhuizen KU Leuven
Target Recruit Count
42
Registration Number
NCT01291472
Locations
🇧🇪

University Hospitals Leuven, Leuven, Belgium

Valproate Versus Ketorolac Versus Metoclopramide

Phase 4
Completed
Conditions
Acute Migraine
Interventions
First Posted Date
2010-12-29
Last Posted Date
2018-06-04
Lead Sponsor
Montefiore Medical Center
Target Recruit Count
330
Registration Number
NCT01267864
Locations
🇺🇸

Montefiore Medical Center, Bronx, New York, United States

Study of Whether 15 mg Dose of Ketorolac IV is as Effective as a 30 mg Dose.

Not Applicable
Conditions
Pain
Pain, Postoperative
Interventions
First Posted Date
2010-10-29
Last Posted Date
2010-10-29
Lead Sponsor
University of Calgary
Target Recruit Count
50
Registration Number
NCT01230463
Locations
🇨🇦

Foothills Medical Centre, Calgary, Alberta, Canada

Ketorolac Effects on Post-operative Pain and Bone Healing

Not Applicable
Terminated
Conditions
Bunion
Interventions
Drug: Placebo
Drug: Ketorolac
First Posted Date
2010-05-31
Last Posted Date
2019-08-21
Lead Sponsor
Beth Israel Deaconess Medical Center
Target Recruit Count
18
Registration Number
NCT01133639
Locations
🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Efficacy of Multimodal Perioperative Analgesia With Periarticular Drug Injection in Total Knee Arthroplasty(TKA)

Not Applicable
Completed
Conditions
Osteoarthritis,Knee
Interventions
First Posted Date
2010-01-05
Last Posted Date
2013-11-08
Lead Sponsor
Towson Orthopaedic Associates
Target Recruit Count
160
Registration Number
NCT01042093
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