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Ketorolac

Generic Name
Ketorolac
Brand Names
Acular, Acuvail, Omidria, Readysharp Anesthetics Plus Ketorolac, Sprix, Toradol, Toronova Suik
Drug Type
Small Molecule
Chemical Formula
C15H13NO3
CAS Number
74103-06-3
Unique Ingredient Identifier
YZI5105V0L
Background

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and is commercially available as an oral tablet, injectable, nasal spray and as an ophthalmic solution.

It's analgesic properties make it a useful pain management tool across many settings including postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. Impressively, ketorolac has a similar efficacy to standard doses of morphine and meperidine making it a useful opioid sparing agent.

Indication

Ketorolac is a Non-steroidal anti-inflammatory drug (NSAID) and has antipyretic, analgesic and anti-inflammatory properties. It is indicated for short term management of acute pain that requires the calibre of pain management offered by opioids. Clinicians may choose to initiate ketorolac to manage post-operative pain, spinal and soft tissue pain, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, menstrual disorders and headaches among other ailments. Regardless of the etiology of pain, patients should use the lowest possible dose, and avoid using ketorolac for an extended period of time (ideally ≤ 5 days). A benefit of choosing ketorolac over other analgesics with similar potency is that that there does not appear to be a risk of dependence or tolerance with ketorolac use.

Associated Conditions
Acute Migraine, Eye Pain, Inflammation, Macular Edema, Cystoid, Ocular Itching, Pericarditis Acute, Pseudophakic Cystoid Macular Oedema, Severe Acute Pain, Acute, moderate Pain, Chronic aphakic cystoid macular edema, Intraoperative miosis, Postoperative ocular pain

Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy

Phase 2
Completed
Conditions
Bunionectomy
Orthopedic Surgery
First Posted Date
2006-02-17
Last Posted Date
2012-12-03
Lead Sponsor
POZEN
Target Recruit Count
100
Registration Number
NCT00293631
Locations
🇺🇸

Advanced Clinical Research Institute, Anaheim, California, United States

Use of Ketorolac in Management of Post-Operative Pain After Heart Surgery

Phase 4
Completed
Conditions
Pain Management Following Cardiopulmonary Bypass Surgery
Interventions
Other: Placebo
First Posted Date
2005-09-12
Last Posted Date
2009-05-13
Lead Sponsor
Weill Medical College of Cornell University
Target Recruit Count
25
Registration Number
NCT00161577
Locations
🇺🇸

New York Presbyterian Hospital, Weill Cornell Medical College, New York, New York, United States

Randomized, Double Blind, Placebo-Controlled, Phase IIB Trial of Ketorolac Mouth Rinse Evaluating the Effect of Cyclooxygenase Inhibition on Oropharyngeal Leukoplakia: Collaborative Study of the NCI, NIDCD and the NIDCR

Phase 2
Completed
Conditions
Leukoplakia
Periodontal Disease
First Posted Date
1999-11-04
Last Posted Date
2008-03-04
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
57
Registration Number
NCT00001698
Locations
🇺🇸

National Cancer Institute (NCI), Bethesda, Maryland, United States

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