扎鲁司特 (Accolate)

概览

Zafirlukast is a leukotriene receptor antagonist used for prophylaxis and chronic treatment of asthma.

作用机制

Zafirlukast is a selective and competitive receptor antagonist of leukotriene D4 and E4 (LTD and LTE4), components of slow-reacting substance of anaphylaxis (SRSA). Cysteinyl leukotriene production and receptor occupation have been correlated with the pathophysiology of asthma, including airway edema, smooth muscle constriction, and altered cellular activity associated with the inflammatory process, which contribute to the signs and symptoms of asthma.

适应症

For the prophylaxis and chronic treatment of asthma.

• Asthma
• Chronic Urticaria