硝酸布康唑 (Gynazole-1)

概览

Butoconazole is an imidazole antifungal used to treat vulvovaginal candidiasis.

作用机制

The exact mechanism of the antifungal action of butoconazole is unknown, however, it is presumed to function as other imidazole derivatives via inhibition of steroid synthesis. Imidazoles generally inhibit the conversion of lanosterol to ergosterol via the inhibition of the enzyme cytochrome P450 14α-demethylase, resulting in a change in fungal cell membrane lipid composition. This structural change alters cell permeability and, ultimately, results in the osmotic disruption or growth inhibition of the fungal cell.

适应症

For the local treatment of vulvovaginal candidiasis (infections caused by Candida)

• Vulvovaginal Candidiasis