Nitazoxanide
- Generic Name
- Nitazoxanide
- Brand Names
- Alinia, Busulfex
- Drug Type
- Small Molecule
- Chemical Formula
- C12H9N3O5S
- CAS Number
- 55981-09-4
- Unique Ingredient Identifier
- SOA12P041N
- Background
Nitazoxanide belongs to the class of drugs known as thiazolides. Nitazoxanide (NTZ) is a broad-spectrum anti-infective drug that markedly modulates the survival, growth, and proliferation of a range of extracellular and intracellular protozoa, helminths, anaerobic and microaerophilic bacteria, in addition to viruses. This drug is effective in the treatment of gastrointestinal infections including Cryptosporidium parvum or Giardia lamblia in healthy subjects. It is generally well tolerated. Nitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment of illnesses caused by other protozoa or helminths . Recently, this drug has been studied as a broad-spectrum antiviral agent due to its ability to inhibit the replication of several RNA and DNA viruses .
- Indication
用于治疗隐孢子虫、贾第鞭毛虫、阿米巴原虫引起的原虫性腹泻。
- Associated Conditions
- Diarrhea caused by Cryptosporidium parvum, Diarrhea caused by Giardia lamblia
- Associated Therapies
- -
Study of Nitazoxanide, Peginterferon Alfa-2a and Ribavirin for the Treatment of Hepatitis C
- Conditions
- Chronic Hepatitis C
- Interventions
- First Posted Date
- 2007-07-03
- Last Posted Date
- 2014-05-08
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 64
- Registration Number
- NCT00495391
- Locations
- 🇺🇸
VA Palo Alto Healthcare System, Palo Alto, California, United States
🇺🇸McGuire VA Medical Center, Richmond, Virginia, United States
🇺🇸Nashville Medical Research Institute, Nashville, Tennessee, United States
Study of Nitazoxanide, Peginterferon, and Ribavirin Combination Therapies in the Treatment of Chronic Hepatitis C
- Conditions
- Chronic Hepatitis C
- Interventions
- First Posted Date
- 2007-01-12
- Last Posted Date
- 2008-09-25
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 121
- Registration Number
- NCT00421434
- Locations
- 🇪🇬
Department of Tropical Medicine & Infectious Diseases, Alexandria University, Alexandria, Egypt
🇪🇬Department of Tropical Medicine & Infectious Diseases, Tanta University School of Medicine, Tanta, Egypt
Study of Nitazoxanide in the Treatment of Chronic Hepatitis C
- Conditions
- Chronic Hepatitis C
- First Posted Date
- 2007-01-05
- Last Posted Date
- 2007-01-05
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 50
- Registration Number
- NCT00418639
- Locations
- 🇪🇬
Department of Tropical Medicine & Infectious Diseases, Tanta University School of Medicine, Tanta, Egypt
🇪🇬Cairo Liver & GIT Center, Cairo, Egypt
🇪🇬Department of Tropical Medicine & Infectious Diseases, Alexandria University, Alexandria, Egypt
Study of Nitazoxanide in the Treatment of Clostridium Difficile Colitis
- Conditions
- Clostridium Difficile
- First Posted Date
- 2007-01-04
- Last Posted Date
- 2007-01-04
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 114
- Registration Number
- NCT00417872
- Locations
- 🇺🇸
WellStar Infectious Diseases, Marietta, Georgia, United States
🇺🇸The Reading Hospital and Medical Center, West Reading, Pennsylvania, United States
🇺🇸Remington-Davis, Inc., and Riverside Infection Consultants, Inc., Columbus, Ohio, United States
Study of Nitazoxanide in the Treatment of Clostridium Difficile-associated Disease
- First Posted Date
- 2006-10-06
- Last Posted Date
- 2015-05-05
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 50
- Registration Number
- NCT00384527
- Locations
- 🇺🇸
Michael E. Debakey VAMC, Houston, Texas, United States
🇺🇸Bay Pines VAMC, Bay Pines, Florida, United States
🇺🇸John D. Dingell VAMC, Ann Arbor, Michigan, United States
Study of Nitazoxanide in the Treatment of Amebiasis in Children
- Conditions
- Amebiasis
- First Posted Date
- 2006-08-21
- Last Posted Date
- 2006-08-21
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 50
- Registration Number
- NCT00366730
- Locations
- 🇪🇬
Benha University Hospital, Benha, Egypt
🇪🇬University Hospital, Alexandria, Egypt
Study of Nitazoxanide in the Treatment of Amebiasis in Adults and Adolescents
- Conditions
- Amebiasis
- First Posted Date
- 2006-08-21
- Last Posted Date
- 2006-08-21
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 50
- Registration Number
- NCT00366236
- Locations
- 🇪🇬
Benha University Hospital, Benha, Egypt
🇪🇬University Hospital, Alexandria, Egypt
Compassionate Use of Nitazoxanide for the Treatment of Clostridium Difficile Infection
- Conditions
- Pseudomembranous ColitisClostridium Enterocolitis
- Interventions
- First Posted Date
- 2006-03-17
- Last Posted Date
- 2017-12-15
- Lead Sponsor
- Daniel M. Musher MD
- Target Recruit Count
- 22
- Registration Number
- NCT00304356
- Locations
- 🇺🇸
Baylor College of Medicine, Houston, Texas, United States
🇺🇸Michael E. Debakey VA Medical Center, Houston, Texas, United States
Study of Nitazoxanide Tablets in the Treatment of Mild to Moderate Active Crohn's Disease
- First Posted Date
- 2005-08-15
- Last Posted Date
- 2012-05-31
- Lead Sponsor
- Romark Laboratories L.C.
- Target Recruit Count
- 98
- Registration Number
- NCT00130390
- Locations
- 🇺🇸
Gastrointestinal Associates, LLC, Kingsport, Tennessee, United States
🇺🇸Nashville Medical Research, Nashville, Tennessee, United States
🇺🇸Romark Laboratories, L.C., Tampa, Florida, United States
Nitazoxanide for the Treatment of Chronic Diarrhea in HIV Infected Children
- Conditions
- HIV InfectionsCryptosporidiosis
- First Posted Date
- 2003-02-20
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 6
- Registration Number
- NCT00055107
- Locations
- 🇹🇭
Siriraj Hospital Mahidol University CRS, Bangkok, Thailand
🇿🇦Stellenbosch Univ. CRS, Cape Town, South Africa
Drug Development Updates
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