Trimetrexate
- Generic Name
- Trimetrexate
- Brand Names
- Neutrexin
- Drug Type
- Small Molecule
- Chemical Formula
- C19H23N5O3
- CAS Number
- 52128-35-5
- Unique Ingredient Identifier
- UPN4ITI8T4
Overview
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Background
A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Indication
用于白血病及各种实体瘤，如非小细胞癌、结直肠癌、前列腺癌、膀胱癌、胃癌、乳腺癌、胰腺癌、宫颈癌等。
Associated Conditions
- Pneumocystis Jirovecii Pneumonia
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2005/07/13 | Phase 1 | Completed | |||
2004/08/18 | Phase 2 | Completed | |||
2004/08/12 | Phase 2 | Completed | |||
2004/04/09 | Phase 2 | Completed | Grupo Oncologico Cooperativo del Sur | ||
2003/01/27 | Phase 2 | Completed | |||
2001/08/31 | Phase 1 | Completed | U.S. Bioscience | ||
2001/08/31 | Phase 1 | Completed | |||
2001/08/31 | Phase 3 | Completed | |||
2001/08/31 | Phase 3 | Completed | |||
2001/08/31 | Not Applicable | Completed | U.S. Bioscience |
FDA Approved Products
Product Name | Manufacturer | Route | Strength | Approved | NDC Code |
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No FDA products found
No FDA products found for this drug
EMA Approved Products
Medicine Name | EMA Number | Auth. Holder | Country | Drug Type | Status | Issued | Opinion | Revision |
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No EMA products found
No EMA products found for this drug
HSA Approved Products
Product Name | Manufacturer | Dosage Form | Strength | Approved | Approval No. |
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No HSA products found
No HSA products found for this drug
NMPA Approved Products
Product Name | Approval No. | Manufacturer | Dosage Form | Trade Name | Strength | Type | Status | Date | Import |
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No NMPA products found
No NMPA products found for this drug
PPB Approved Products
Product Name | Registration Code | Company | Category | Sale Type | Reg. Date |
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No PPB products found
No PPB products found for this drug
TGA Approved Products
Product Name | ARTG ID | Sponsor | Status | Reg. Date | Ingredient |
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No TGA products found
No TGA products found for this drug