Refractory anaplastic astrocytoma (WHO grade III) and Glioblastoma multiforme (WHO grade IV) are primary malignant brain tumours with poor prognosis and limited treatment options. Despite considerable genetic heterogeneity, these tumours often have impaired DNA repair systems, rendering them initially sensitive to alkylating agents, although they invariably ...
Temozolomide is indicated in adult patients for the treatment of newly diagnosed glioblastoma concomitantly with radiotherapy and for use as maintenance treatment thereafter. It is also indicated for the treatment of refractory anaplastic astrocytoma in adult patients or adjuvant therapy for adults with newly diagnosed anaplastic astrocytoma.
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Memorial Sloan-Kettering Cancer Center at Commack, Commack, New York, United States
Memorial Sloan-Kettering at Basking Ridge, Basking Ridge, New Jersey, United States
Memorial Sloan-Kettering Cancer Center, New York, New York, United States
University of Washington/Seattle Cancer Care Alliance, Seattle, Washington, United States
Edmond Odette Cancer Centre at Sunnybrook, Toronto, Ontario, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
Allan Blair Cancer Centre at Pasqua Hospital, Regina, Saskatchewan, Canada
UCSF Department of Neurological Surgery, San Francisco, California, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Beth Israel Deaconness Medical Center, Boston, Massachusetts, United States
Brigham and Women's Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Insitute, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Lehigh Valley Hospital - Muhlenberg, Bethlehem, Pennsylvania, United States
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, New York, New York, United States
Hopital Sainte Justine, Montreal, Quebec, Canada
Daniel Den Hoed Cancer Center at Erasmus Medical Center, Rotterdam, Netherlands
Klinikum der Universitaet Regensburg, Regensburg, Germany
U.Z. Gasthuisberg, Leuven, Belgium
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