Aspirin

Generic Name: Aspirin

Brand Names: Aggrenox, Alka-seltzer, Alka-seltzer Fruit Chews, Anacin, Arthriten Inflammatory Pain, Ascomp, Aspi-cor, Aspir-low, Bayer Aspirin, Bayer Womens, Bc Arthritis, Bc Original Formula, Bufferin, Duoplavin, Durlaza, Ecotrin, Ecpirin, Endodan Reformulated May 2009, Equagesic, Exaprin, Excedrin, Excedrin PM Triple Action, Fasprin, Fiorinal, Goody's Body Pain, Goody's Extra Strength, Goody's PM, Miniprin, Norgesic, Norgesic Forte, Orphengesic, Pamprin Max Formula, Robaxisal, ST. Joseph Aspirin, Stanback Headache Powder Reformulated Jan 2011, Trianal, Trianal C, Vanquish, Vazalore, Yosprala

Drug Type: Small Molecule

Chemical Formula: C_₉H_₈O_₄

CAS Number: 50-78-2

Unique Ingredient Identifier: R16CO5Y76E

Background: Also known as Aspirin, acetylsalicylic acid (ASA) is a commonly used drug for the treatment of pain and fever due to various causes. Acetylsalicylic acid has both anti-inflammatory and antipyretic effects. This drug also inhibits platelet aggregation and is used in the prevention of blood clots stroke, and myocardial infarction (MI) .
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Indication: Pain, fever, and inflammation
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Associated Conditions: Acute Coronary Syndrome (ACS), Anxiety, Atherothrombotic cerebral infarction, Cardiovascular Disease (CVD), Cardiovascular Events, Cardiovascular Mortality, Colorectal Adenomas, Colorectal Cancer, Common Cold, Coronary artery reocclusion, Death, Dyspeptic signs and symptoms, Fever, Flu caused by Influenza, Headache, Heterozygous Familial Hypercholesterolemia (HeFH), Inflammation, Juvenile Idiopathic Arthritis (JIA), Major Adverse Cardiovascular and Cerebrovascular Events (MACCE), Menstrual Pain, Migraine, Morbidity, Mucocutaneous Lymph Node Syndrome, Muscle Contraction, Myalgia, Myocardial Infarction, Myocardial Infarction (MI), first occurrence, Neuropathic Pain, Pain, Pain caused by Common Cold, Pain caused by Rheumatism, Pericarditis, Polycythemia Vera (PV), Pre-Eclampsia, Rheumatism, Rheumatoid Arthritis, Rhino Sinusitis, Severe Pain, Spondyloarthropathies, Stroke, Systemic Lupus Erythematosus, Tension Headache, Thromboembolism, Thrombosis, Toothache, Transient Ischemic Attack, Vascular Death, Venous Thromboembolism, Acute Inflammation, Articular inflammation, Atherothrombotic events, Death caused by Myocardial Infarction, Fever or influenza-like illness, Moderate Pain, Recurrent Ischemic Stroke

Associated Therapies: Anti-platelet Therapy, Hemodialysis Treatment, Secondary Prevention

Clinical Trials

Early Prediction and Randomised Prevention of Preeclampsia With Low Dose Aspirin in Chinese Cohort

Phase 4

Conditions: Preeclampsia

Interventions: Drug: Aspirin

First Posted Date: 2020-11-17

Last Posted Date: 2020-11-17

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 1500

Registration Number: NCT04631627

Transplacental Aspirin Therapy for Early Onset Fetal Growth Restriction

Phase 3

Withdrawn

Conditions: Fetal Growth Restriction
Intrauterine Growth Retardation
Intrauterine Growth Restriction
Fetal Growth Retardation

Interventions: Drug: Aspirin

First Posted Date: 2020-09-21

Last Posted Date: 2021-06-16

Lead Sponsor: Johns Hopkins University

Registration Number: NCT04557475

Efficacy of Immunoglobulin Plus Infliximab for the Early Regression of Coronary Artery Lesion in Kawasaki Disease

Phase 3

Withdrawn

Conditions: Kawasaki Disease

Interventions: Drug: IVIG
Drug: Aspirin
Drug: Infliximab

First Posted Date: 2020-09-02

Last Posted Date: 2021-03-12

Lead Sponsor: Children's Hospital of Fudan University

Registration Number: NCT04535518

Locations: 🇨🇳
Shanghai Children's Hospital, Shanghai, China
🇨🇳
Shanghai Children's Medical Center, Shanghai, China
🇨🇳
Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China

and more 2 locations

Regorafenib in Combination With Metronomic Chemotherapies, and Low-dose Aspirin in Metastatic Colorectal Cancer

Phase 2

Completed

Conditions: Colo-rectal Cancer
Metastatic Cancer

Interventions: Drug: Regorafenib
Drug: Cyclophosphamide
Drug: Capecitabine
Drug: Aspirin

First Posted Date: 2020-09-01

Last Posted Date: 2024-12-20

Lead Sponsor: Centre Hospitalier Universitaire de Besancon

Target Recruit Count: 49

Registration Number: NCT04534218

Locations: 🇫🇷
Hôpital Nord Franche-Comté, Montbéliard, France
🇫🇷
CHU de Besançon, Besançon, France
🇫🇷
Centre georges-François Leclerc, Dijon, France

COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-80

Phase 3

Terminated

Conditions: COVID-19

Interventions: Drug: Apixaban 2.5 MG
Drug: Apixaban 5MG
Drug: Placebo
Drug: Aspirin

First Posted Date: 2020-08-04

Last Posted Date: 2022-02-17

Lead Sponsor: Frank C Sciurba

Target Recruit Count: 657

Registration Number: NCT04498273

Locations: 🇺🇸
University of Illinois at Chicago, Chicago, Illinois, United States
🇺🇸
Olivo Wellness Medical Center, Chicago, Illinois, United States
🇺🇸
UPMC Presby, Pittsburgh, Pennsylvania, United States

and more 66 locations

Hemostasis in COVID-19: an Adaptive Clinical Trial

Phase 2

Conditions: COVID-19

Interventions: Drug: acetylsalicylic acid
Drug: Unfractionated heparin nebulized

First Posted Date: 2020-07-10

Last Posted Date: 2021-06-09

Lead Sponsor: University of Sao Paulo General Hospital

Target Recruit Count: 379

Registration Number: NCT04466670

Locations: 🇧🇷
Vanderson Rocha, Sao Paulo, Brazil

Pathways of Eicosanoid Metabolism

Early Phase 1

Conditions: Metabolism of Prostaglandin D2

Interventions: Dietary Supplement: niacin
Other: PGD2
Drug: aspirin

First Posted Date: 2020-07-09

Last Posted Date: 2024-06-14

Lead Sponsor: Vanderbilt University

Target Recruit Count: 10

Registration Number: NCT04464070

Locations: 🇺🇸
Vanderbilt University, Nashville, Tennessee, United States

Genetic and Dietary Predictors of Anti-platelet Response

Phase 4

Terminated

Conditions: Platelet Function

Interventions: Drug: Aspirin

First Posted Date: 2020-07-02

Last Posted Date: 2023-12-15

Lead Sponsor: University of Washington

Target Recruit Count: 126

Registration Number: NCT04456608

Locations: 🇺🇸
University of Montana, Missoula, Montana, United States
🇺🇸
Oregon Health & Sciences University, Portland, Oregon, United States
🇺🇸
Southcentral Foundation, Anchorage, Alaska, United States