Ketamine

Generic Name: Ketamine

Brand Names: Ketalar

Drug Type: Small Molecule

Chemical Formula: C_₁₃H_₁₆ClNO

CAS Number: 6740-88-1

Unique Ingredient Identifier: 690G0D6V8H

Background: Ketamine is an NMDA receptor antagonist with a potent anesthetic effect. It was developed in 1963 as a replacement for phencyclidine (PCP) by Calvin Stevens at Parke Davis Laboratories. It started being used for veterinary purposes in Belgium and in 1964 was proven that compared to PCP, it produced minor hallucinogenic effects and shorter psychotomimetic eff...

Indication: Ketamine is indicated as an anesthetic agent for recommended diagnostic and surgical procedures. If skeletal muscle relaxation is needed, it should be combined with a muscle relaxant. If the surgical procedure involves visceral pain, it should be supplemented with an agent that obtunds visceral pain. Ketamine can be used for induction of anesthesia prior oth...

Associated Conditions: -

Associated Therapies: General Anesthesia, Induction and Maintenance of General Anesthesia

Clinical Trials

The Effect of Ketamine on Interleukin-6 Synthesis in Hepatic Resections Requiring Temporary Porto-arterial Occlusion

Phase 4

Completed

Conditions: Hepatectomy

Interventions: Other: Placebo
Drug: Ketamine

First Posted Date: 2009-09-17

Last Posted Date: 2019-01-15

Lead Sponsor: Hospital Italiano de Buenos Aires

Target Recruit Count: 42

Registration Number: NCT00978757

Locations: 🇦🇷
Hospital Italiano de Buenos Aires, Ciudad Autonoma de Buenos Aires, Argentina

Oral Ketamine Administration in Patients With Peripheral Neuropathic Pain

Phase 2

Completed

Conditions: Neuropathic Pain

Interventions: Drug: Ketamine

First Posted Date: 2009-08-18

Last Posted Date: 2014-12-02

Lead Sponsor: University Hospital, Toulouse

Target Recruit Count: 22

Registration Number: NCT00961194

Locations: 🇫🇷
Service de Neurochirurgie, Toulouse, France

Treatment Study of Bipolar Depression

Phase 4

Terminated

Conditions: Bipolar Disorder

Interventions: Drug: ketamine
Drug: midazolam

First Posted Date: 2009-07-28

Last Posted Date: 2017-05-17

Lead Sponsor: Icahn School of Medicine at Mount Sinai

Target Recruit Count: 1

Registration Number: NCT00947791

Locations: 🇺🇸
Mount Sinai School of Medicine, New York, New York, United States

Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain

Not Applicable

Completed

Conditions: Chronic Low Back Pain

Interventions: Drug: Ketamine
Other: Normal saline

First Posted Date: 2009-05-12

Last Posted Date: 2018-10-18

Lead Sponsor: Dartmouth-Hitchcock Medical Center

Target Recruit Count: 102

Registration Number: NCT00899600

Locations: 🇺🇸
Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity

Not Applicable

Completed

Conditions: Chronic Cough

Interventions: Drug: ketamine

First Posted Date: 2009-03-10

Last Posted Date: 2013-06-19

Lead Sponsor: Jacky Smith

Target Recruit Count: 24

Registration Number: NCT00858624

Locations: 🇬🇧
University of Manchester, Education and Research Centre, Wythenshawe Hospital, Manchester, United Kingdom

Effect of Ketamine on Opioid-Induced Hyperalgesia

Not Applicable

Completed

Conditions: Pain
Chronic Pain
Hyperalgesia

Interventions: Drug: Placebos
Drug: Ketamine

First Posted Date: 2009-02-02

Last Posted Date: 2020-07-23

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 79

Registration Number: NCT00833755

Locations: 🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Percutaneous Ketamine Versus Lidocaine for Mid-Sternotomy

Phase 4

Conditions: Sternotomy

Interventions: Drug: ketamine
Drug: non-drug cream
Drug: lidocaine

First Posted Date: 2009-01-14

Last Posted Date: 2009-01-14

Lead Sponsor: Tel-Aviv Sourasky Medical Center

Target Recruit Count: 75

Registration Number: NCT00822419

Locations: 🇮🇱
Tel Aviv Sourasky Medical center, Tel Aviv, Israel

Percutaneous Ketamine Versus Lidocaine or Placebo, for Post-Surgery Analgesia, in Patients Undergoing Laparoscopic Partial Lung Resection

Phase 4

Conditions: Postoperative Pain

Interventions: Drug: non-active drug cream
Drug: lidocaine
Drug: ketamine

First Posted Date: 2009-01-14

Last Posted Date: 2009-01-14

Lead Sponsor: Tel-Aviv Sourasky Medical Center

Target Recruit Count: 75

Registration Number: NCT00822133

Locations: 🇮🇱
Tel Aviv Sourasky Medical center, Tel Aviv, Israel

Optimization of IV Ketamine for Treatment Resistant Depression

Phase 2

Completed

Conditions: Major Depressive Disorder (MDD)
Treatment Resistant Depression (TRD)

Interventions: Drug: Midazolam
Drug: Ketamine

First Posted Date: 2008-10-08

Last Posted Date: 2014-01-31

Lead Sponsor: Baylor College of Medicine

Target Recruit Count: 73

Registration Number: NCT00768430

Locations: 🇺🇸
Michael E. Dabakey VA Medical Center & Baylor College of Medicine, Houston, Texas, United States
🇺🇸
Mount Sinai School of Medicine, New York, New York, United States

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Phase 2

Completed

Conditions: Depression
PTSD
Anxiety Disorder
Stress Disorders, Post-Traumatic

Interventions: Drug: Ketamine
Drug: Midazolam

First Posted Date: 2008-09-09

Last Posted Date: 2018-02-14

Lead Sponsor: Dennis Charney

Target Recruit Count: 41

Registration Number: NCT00749203

Locations: 🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

Drug Development Updates

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