Phenylephrine
- Generic Name
- Phenylephrine
- Brand Names
- 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
- Drug Type
- Small Molecule
- Chemical Formula
- C9H13NO2
- CAS Number
- 59-42-7
- Unique Ingredient Identifier
- 1WS297W6MV
- Background
Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.
Phenylephrine was granted FDA approval in 1939.
- Indication
Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation is used to treat hemorrhoids. Off-label uses include priapism and induction of local vasoconstriction.
- Associated Conditions
- Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
- Associated Therapies
- Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy
Aussie law firm sues pharma giant Johnson & Johnson over claims its cold and flu drugs don't work
Johnson & Johnson faces a class action in Australia for allegedly selling ineffective cold and flu medications containing phenylephrine, misleading consumers about their efficacy. The lawsuit seeks compensation for buyers since 2005, highlighting concerns over medication trust and the need for informed consumer choices.
Australian law firm files class action against Johnson & Johnson over 'ineffective' cold and flu medication
An Australian law firm accuses Johnson & Johnson of selling ineffective cold medications containing phenylephrine, deemed ineffective by the FDA. The lawsuit seeks compensation for consumers misled by the company's claims, highlighting the ineffectiveness of oral phenylephrine compared to nasal sprays.
FDA moves to pull popular decongestant from shelves amid effectiveness concerns
The FDA proposed removing oral phenylephrine from the market due to its ineffectiveness as a nasal decongestant, launching a six-month public comment period. CVS stopped selling products containing phenylephrine last year, but other major pharmacies still stock them. The FDA's proposal targets only oral forms of the drug, not nasal sprays. The Consumer Healthcare Products Association opposes the move, arguing that phenylephrine should remain available for consumer choice.
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A study by Fakayode et al. combines Raman and UV-visible spectroscopy with PCA and PLS regression to quantify active ingredients in OTCM syrups, offering a rapid, cost-effective method for quality control, crucial for detecting counterfeit drugs.
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