Phenylephrine

Generic Name
Phenylephrine
Brand Names
4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain
Drug Type
Small Molecule
Chemical Formula
C9H13NO2
CAS Number
59-42-7
Unique Ingredient Identifier
1WS297W6MV
Background

Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication

Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation ...

Associated Conditions
Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes
Associated Therapies
Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Phenylephrine in Spinal Anesthesia in Preeclamptic Patients

Not Applicable
Completed
Conditions
Interventions
First Posted Date
2007-04-09
Last Posted Date
2022-06-02
Lead Sponsor
Northwestern University
Target Recruit Count
110
Registration Number
NCT00458003
Locations
🇺🇸

Northwestern University, Chicago, Illinois, United States

🇺🇸

Northwestern Memorial Hospital, Chicago, Illinois, United States

Mechanisms of Choroidal Blood Flow Changes During Dark/Light Transitions

Phase 2
Completed
Conditions
First Posted Date
2007-02-05
Last Posted Date
2007-02-05
Lead Sponsor
Medical University of Vienna
Target Recruit Count
42
Registration Number
NCT00431392
Locations
🇦🇹

Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria

Ideal Dose of Phenylephrine to Treat Low Blood Pressure During Cesarean Section

Not Applicable
Completed
Conditions
First Posted Date
2006-09-22
Last Posted Date
2007-03-21
Lead Sponsor
Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Target Recruit Count
50
Registration Number
NCT00379691
Locations
🇨🇦

Mount Sinai Hospital, Toronto, Ontario, Canada

The Use of Nasal Phenylephrine in Infants With Bronchiolitis

Phase 2
Completed
Conditions
First Posted Date
2006-09-08
Last Posted Date
2009-01-12
Lead Sponsor
Akron Children's Hospital
Target Recruit Count
50
Registration Number
NCT00373802

Hemodynamic Measurements During Cesarean Section With Spinal Anesthesia

Phase 4
Completed
Conditions
First Posted Date
2005-09-20
Last Posted Date
2011-07-06
Lead Sponsor
Oslo University Hospital
Target Recruit Count
80
Registration Number
NCT00199784
Locations
🇳🇴

Rikshospitalet-Radiumhospitalet HF, Oslo, Norway

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