Phenylephrine

Generic Name: Phenylephrine

Brand Names: 4-way, Advil Congestion Relief, Advil Sinus Congestion and Pain, Ala-hist PE, Allerest PE, Benadryl-D Allergy and Sinus, Biorphen, Cyclomydril, Dayquil Sinex, Deconex, Despec Reformulated Jun 2008, Dimetapp Nighttime Cold & Congestion, Diphen, Entex Lq, Gilphex, Histex Ac, Immphentiv, Little Noses Decongestant, M-end PE, Mucinex Stuffy Nose & Cold, Mydcombi, Mydfrin, Nasopen PE, Neo-synephrine, Omidria, Poly Hist Forte Reformulated Nov 2013, Preparation H Cooling Gel, Preparation H Cream, Preparation H Reformulated Jun 2013, Refenesen PE, Rescon-GG, Rymed-D, Soframycin, Sudafed PE, Sudafed PE Children's Cold & Cough, Sudafed PE Children's Nasal Decongestant, Sudafed PE Head Congestion Plus Pain, Sudafed PE Sinus Headache, Sudo-tab, Sudogest PE, Triaminic Day Time Cold & Cough, Triaminic Night Time Cold & Cough, Vazculep, Wal-profen Congestion Relief and Pain

Drug Type: Small Molecule

Chemical Formula: C_₉H_₁₃NO_₂

CAS Number: 59-42-7

Unique Ingredient Identifier: 1WS297W6MV

Background: Phenylephrine is an alpha-1 adrenergic receptor agonist used to treat hypotension, dilate the pupil, and induce local vasoconstriction. The action of phenylephrine, or neo-synephrine, was first described in literature in the 1930s.

Phenylephrine was granted FDA approval in 1939.

Indication: Phenylephrine is available in various drug formulations, which have different indications. Phenylephrine injections are indicated to treat hypotension caused by shock or anesthesia. The ophthalmic formulation is indicated to induce mydriasis and conjunctival vasoconstriction. The intranasal formulation is used to treat congestion, and a topical formulation ...

Associated Conditions: Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergy to Tree Pollen, Anorectal discomfort, Cold, Common Cold, Congestion of the Conjunctivas, Cough, Cough caused by Common Cold, Eye allergy, Eye redness, Fever, Flu caused by Influenza, Haemorrhoids, Headache, Headache caused by Allergies, Headache caused by Common Cold, Headache caused by Pollen Allergy, Hypotension, Irritative cough, Itching of the nose, Itching of the throat, Laryngotracheitis, Nasal Congestion, Nose discomfort, Ocular Inflammation, Ocular Irritation, Paroxysmal Supraventricular Tachycardia (PSVT), Respiratory tract congestion, Respiratory tract irritation, Rhinopharyngitis, Rhinorrhoea, Seasonal Allergies, Sinus Congestion, Sinus pressure, Sinusitis, Sneezing, Sore Throat, Tracheobronchitis, Upper respiratory tract hypersensitivity reaction, site unspecified, Vasomotor Rhinitis, Aching caused by Flu caused by Influenza, Bronchial congestion, Cold or flu syndrome, Itchy throat, Minor aches and pains, Vascular failure, Watery itchy eyes

Associated Therapies: Airway secretion clearance therapy, Mydriasis, Antihistamine, Vasoconstrictor in regional analgesia therapy

Clinical Trials

The Impact of Carbon Monoxide and Altitude on Vascular Function

Not Applicable

Completed

Conditions: Vasodilation
Vasoconstriction

Interventions: Other: Carbon monoxide rebreathe
Drug: Sodium Nitroprusside
Drug: Phenylephrine Hydrochloride

First Posted Date: 2021-06-16

Last Posted Date: 2022-05-25

Lead Sponsor: University of Alberta

Target Recruit Count: 19

Registration Number: NCT04928183

Locations: 🇨🇦
University of Alberta, Edmonton, Alberta, Canada

Comparing Between CO2 and Phenylephrine Treatment in Patients With Progressive Lacunar Infarction (CARBOGEN Study)

Phase 3

Conditions: Acute Ischemic Stroke

Interventions: Drug: carbogen
Drug: phenylephrine

First Posted Date: 2021-04-09

Last Posted Date: 2021-05-20

Lead Sponsor: Yonsei University

Target Recruit Count: 40

Registration Number: NCT04839224

Locations: 🇰🇷
Yonsei University Health System, Severance Hospital, Seoul, Korea, Republic of

Comparison of Phenylephrine and Norepinephrine for Spinal-induced Hypotension

Phase 3

Completed

Conditions: Spinal Induced-hypotension

Interventions: Drug: Phenylephrine
Drug: Norepinephrine

First Posted Date: 2021-03-09

Last Posted Date: 2021-03-09

Lead Sponsor: Tribhuvan University Teaching Hospital, Institute Of Medicine.

Target Recruit Count: 80

Registration Number: NCT04789005

Locations: 🇳🇵
Tribhuvan university teaching hospital, Kathmandu, Bagmati, Nepal

Norepinephrine vs Phenylephrine During General Anesthesia

Phase 4

Completed

Conditions: Anesthesia
Surgery
Hypotension

Interventions: Drug: Norepinephrine
Drug: Phenylephrine

First Posted Date: 2021-03-09

Last Posted Date: 2022-05-05

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 2000

Registration Number: NCT04789330

Locations: 🇺🇸
UCSF Medical Center at Parnassus, San Francisco, California, United States
🇺🇸
UCSF Medical Center at Mission Bay, San Francisco, California, United States
🇺🇸
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States

and more 2 locations