Amorolfine
- Generic Name
- Amorolfine
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C21H35NO
- CAS Number
- 78613-35-1
- Unique Ingredient Identifier
- AB0BHP2FH0
- Background
Amorolfine or amorolfin, is a morpholine antifungal drug that inhibits the fungal enzymes D14 reductase and D7-D8 isomerase. This inhibition affects fungal sterol synthesis pathways, depleting ergosterol and causing ignosterol to accumulate in the fungal cytoplasmic cell membranes. Amorolfine is marketed as Curanail, Loceryl, Locetar, and Odenil. It is avail...
- Indication
外用于治疗由皮肤癣菌如红色毛癣菌、须癣毛癣菌、絮状表皮癣菌和犬小孢子菌等所致的浅表皮肤真菌感染，如手癣、足癣（尤其是角化增厚型）、体癣、股癣；亦可用于头癣；也适用于治疗甲真菌病。外用于由念珠菌如白色念珠菌等所致的皮肤念珠菌感染和念珠菌性外阴阴道炎。外用于由马拉色菌属所致的花斑癣。
- Associated Conditions
- Fungal skin infection, Fungus, Nail, Pityriasis versicolor, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea inguinalis, Tinea manuum, Cutaneous candidiasis
- Associated Therapies
- -
Clinical Investigation for the Evaluation of Efficacy and Safety of Two Medical Devices for Onychomycosis Treatment
- Conditions
- Interventions
- First Posted Date
- 2024-02-12
- Last Posted Date
- 2024-02-12
- Lead Sponsor
- Oystershell NV
- Target Recruit Count
- 132
- Registration Number
- NCT06254027
Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis
- First Posted Date
- 2016-06-23
- Last Posted Date
- 2021-09-28
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 60
- Registration Number
- NCT02812043
- Locations
- 🇹🇭
Department of Dermatology Siriraj Hospital, Bangkoknoi, Bangkok, Thailand
A Randomized Study to Evaluate the Efficacy of Herbal Ingredients Combined With a Carrier System (Phytonail) Compared With Amorolfine 5% Nail Lacquer (Loceryl) in the Treatment of Toenail Onychomycosis
- First Posted Date
- 2013-08-27
- Last Posted Date
- 2013-08-27
- Lead Sponsor
- National Taiwan University Hospital
- Target Recruit Count
- 72
- Registration Number
- NCT01929187
- Locations
- 🇨🇳
National Taiwan University Hospital, Taipei, Taiwan
Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis
- Conditions
- Interventions
- First Posted Date
- 2013-05-10
- Last Posted Date
- 2015-11-30
- Lead Sponsor
- Helsinki University Central Hospital
- Target Recruit Count
- 129
- Registration Number
- NCT01851590
- Locations
- 🇫🇮
Vääksyn Lääkärikeskus, Vääksy, Finland
Drug Development Updates
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