Varlilumab
- Generic Name
- Varlilumab
- Brand Names
- -
- Drug Type
- Biotech
- Chemical Formula
- -
- CAS Number
- 1393344-72-3
- Unique Ingredient Identifier
- 0125DUV5XC
- Background
Varlilumab has been used in trials studying the treatment of MELANOMA, Skin Ulcer, Burkett's Lymphoma, Mantle cell lymphoma, and Any T-cell Malignancy, among others.
- Associated Conditions
- -
- Associated Therapies
- -
Testing A New Combination of Anti-cancer Immune Therapies, Atezolizumab and CDX-1127 (Varlilumab) With or Without the Addition of a Third Anti-cancer Drug, Cobimetinib, for Advanced-Stage Biliary Tract Cancer
Phase 2
Active, not recruiting
- Conditions
- Metastatic Distal Bile Duct AdenocarcinomaUnresectable Liver CarcinomaMetastatic Gallbladder CarcinomaRecurrent Distal Bile Duct AdenocarcinomaMetastatic Intrahepatic CholangiocarcinomaRecurrent Gallbladder CarcinomaRecurrent Intrahepatic CholangiocarcinomaStage IV Distal Bile Duct Cancer AJCC v8Stage IV Gallbladder Cancer AJCC v8Stage IV Intrahepatic Cholangiocarcinoma AJCC v8
- Interventions
- Biological: AtezolizumabProcedure: BiopsyProcedure: Biospecimen CollectionDrug: CobimetinibProcedure: Computed TomographyProcedure: Magnetic Resonance ImagingDrug: Varlilumab
- First Posted Date
- 2021-06-28
- Last Posted Date
- 2024-07-19
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 56
- Registration Number
- NCT04941287
- Locations
- 🇺🇸
UM Sylvester Comprehensive Cancer Center at Aventura, Aventura, Florida, United States
🇺🇸Emory Saint Joseph's Hospital, Atlanta, Georgia, United States
🇺🇸Roswell Park Cancer Institute, Buffalo, New York, United States
Nivolumab With or Without Varlilumab in Treating Patients With Relapsed or Refractory Aggressive B-cell Lymphomas
Phase 2
Active, not recruiting
- Conditions
- High Grade B-Cell Lymphoma With MYC and BCL2 and/or BCL6 RearrangementsHigh Grade B-Cell Lymphoma, Not Otherwise SpecifiedPrimary Effusion LymphomaRefractory Diffuse Large B-Cell LymphomaRefractory T-Cell/Histiocyte-Rich Large B-Cell LymphomaALK-Positive Large B-Cell LymphomaDiffuse Large B-Cell Lymphoma Activated B-Cell TypeDiffuse Large B-Cell Lymphoma Germinal Center B-Cell TypeEBV-Positive Diffuse Large B-Cell Lymphoma, Not Otherwise SpecifiedEBV-Positive Mucocutaneous Ulcer
- Interventions
- First Posted Date
- 2017-02-01
- Last Posted Date
- 2024-12-27
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 54
- Registration Number
- NCT03038672
- Locations
- 🇺🇸
The University of Kansas Cancer Center - Olathe, Olathe, Kansas, United States
🇺🇸Mayo Clinic Hospital in Arizona, Phoenix, Arizona, United States
🇺🇸Mayo Clinic in Arizona, Scottsdale, Arizona, United States
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