MedPath

Ademetionine

Generic Name
Ademetionine
Drug Type
Small Molecule
Chemical Formula
C15H22N6O5S
CAS Number
29908-03-0
Unique Ingredient Identifier
7LP2MPO46S

Overview

Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed)

Indication

S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being.

Associated Conditions

  • Fatigue
  • Intrahepatic Cholestasis
  • Major Depressive Disorder (MDD)

Research Report

Published: May 13, 2025

Ademetionine Report

Name: Ademetionine Name (English): Ademetionine DrugBank ID: DB00118 Type: Small Molecule CAS Number: 29908-03-0

Uses: Ademetionine is used to treat various conditions, including:

  • Liver diseases (e.g., cholestatic liver diseases, alcoholic fatty liver disease, non-alcoholic fatty liver disease, liver disease during pregnancy, liver conditions with reduced bile formation).
  • Depression.
  • Osteoarthritis (to reduce pain and swelling in the joints).
  • Biliary cholangitis (an autoimmune disease of the liver).
  • Excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis.
  • Fibromyalgia symptoms.
  • Nerve problems in people with AIDS.
  • Sexual dysfunction in men with depression.

Mechanism of Action: Ademetionine (S-adenosylmethionine or SAMe) is a naturally occurring compound involved in several crucial biological processes:

  • Methylation: It acts as a methyl donor in the transfer of a methyl group to other molecules like DNA, proteins, and lipids, which is essential for gene expression, protein function, and lipid metabolism.
  • Trans-sulfuration: It participates in the synthesis of cysteine and glutathione, a vital antioxidant that protects liver cells from toxins and oxidative stress.
  • Aminopropylation: It is a precursor in the synthesis of polyamines, which are involved in cellular growth and repair. In liver disease, ademetionine helps maintain glutathione levels, minimizing liver damage and preventing the accumulation of lipids associated with cirrhosis. In depression, it affects neurotransmitters like serotonin, which regulate mood. In osteoarthritis, it may stimulate cartilage production and reduce inflammation.

Continue reading the full research report

FDA Drug Approvals

Approved Product
Manufacturer
NDC Code
Route
Strength
Effective Date
No FDA approvals found for this drug.

EMA Drug Approvals

Approved Product
Authorization Holder
Status
Issued Date
No EMA approvals found for this drug.

HSA Drug Approvals

Approved Product
Manufacturer
Approval Number
Dosage Form
Strength
Approval Date
No HSA approvals found for this drug.

NMPA Drug Approvals

Approved Product
Company
Approval Number
Drug Type
Dosage Form
Approval Date
No NMPA approvals found for this drug.

PPB Drug Approvals

Approved Product
Registration No.
Company
Licence No.
Strength
Registration Date
No PPB approvals found for this drug.

TGA Drug Approvals

Approved Product
ARTG ID
Sponsor
Registration Type
Status
Registration Date
No TGA approvals found for this drug.

Health Canada Drug Approvals

Approved Product
Company
DIN
Dosage Form
Strength
Market Date
No Health Canada approvals found for this drug.

CIMA AEMPS Drug Approvals

Approved Product
Company
Registration Number
Pharmaceutical Form
Prescription Type
Status
No CIMA AEMPS (Spain) approvals found for this drug.

Philippines FDA Drug Approvals

Approved Product
Company
License Number
Dosage Form
Strength
Approval Date
No Philippines FDA approvals found for this drug.

Saudi SFDA Drug Approvals

Approved Product
Company
License Number
Dosage Form
Strength
Approval Date
No Saudi SFDA approvals found for this drug.

Malaysia NPRA Drug Approvals

Approved Product
Company
Registration Number
Dosage Form
Strength
Approval Date
No Malaysia NPRA approvals found for this drug.

UK EMC Drug Information

Medicine Name
MA Holder
MA Number
Pharmaceutical Form
Active Ingredient
Authorization Date
No UK EMC drug information found for this drug.

Help Us Improve

Your feedback helps us provide better drug information and insights.

MedPath

Empowering clinical research with data-driven insights and AI-powered tools.

© 2025 MedPath, Inc. All rights reserved.