Ademetionine

Ademetionine Report

Name: Ademetionine Name (English): Ademetionine DrugBank ID: DB00118 Type: Small Molecule CAS Number: 29908-03-0

Uses: Ademetionine is used to treat various conditions, including:

• Liver diseases (e.g., cholestatic liver diseases, alcoholic fatty liver disease, non-alcoholic fatty liver disease, liver disease during pregnancy, liver conditions with reduced bile formation).
• Depression.
• Osteoarthritis (to reduce pain and swelling in the joints).
• Biliary cholangitis (an autoimmune disease of the liver).
• Excess cholesterol in bile and biliary and liver diseases caused by cystic fibrosis.
• Fibromyalgia symptoms.
• Nerve problems in people with AIDS.
• Sexual dysfunction in men with depression.

Mechanism of Action: Ademetionine (S-adenosylmethionine or SAMe) is a naturally occurring compound involved in several crucial biological processes:

• Methylation: It acts as a methyl donor in the transfer of a methyl group to other molecules like DNA, proteins, and lipids, which is essential for gene expression, protein function, and lipid metabolism.
• Trans-sulfuration: It participates in the synthesis of cysteine and glutathione, a vital antioxidant that protects liver cells from toxins and oxidative stress.
• Aminopropylation: It is a precursor in the synthesis of polyamines, which are involved in cellular growth and repair. In liver disease, ademetionine helps maintain glutathione levels, minimizing liver damage and preventing the accumulation of lipids associated with cirrhosis. In depression, it affects neurotransmitters like serotonin, which regulate mood. In osteoarthritis, it may stimulate cartilage production and reduce inflammation.