MedPath

Hydrogen peroxide

Generic Name
Hydrogen peroxide
Brand Names
Eskata, Orajel Mouth Sore Rinse
Drug Type
Small Molecule
Chemical Formula
H2O2
CAS Number
7722-84-1
Unique Ingredient Identifier
BBX060AN9V
Background

Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition. Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction . As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells .

Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide . It is used in industrial and cosmetic applications as a bleaching agent. Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA ; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks.

Indication

Indicated to be used as a disinfectant and sterilizer.

Associated Conditions
Ear infection bacterial, Seborrheic Keratosis (SK), Impacted ear wax, Superficial skin infections
Associated Therapies
-

Antiseptic Effects on the Dental Implant Internal Surface Microbiome

Early Phase 1
Recruiting
Conditions
Implant Infection
Peri-implant Mucositis
Dental Implant Failed
Peri-Implantitis
Interventions
First Posted Date
2021-08-27
Last Posted Date
2024-12-27
Lead Sponsor
Madigan Army Medical Center
Target Recruit Count
150
Registration Number
NCT05024760
Locations
🇺🇸

Madigan Army Medical Center, Tacoma, Washington, United States

Evaluation of Aerosol in a Dental Clinic

Phase 4
Recruiting
Conditions
Covid19
Interventions
Device: High volume evacuation (HVE)
Device: Extraoral vacuum aspirator (EVA)
Device: External evacuation device (EED)
Drug: Hydrogen Peroxide
First Posted Date
2020-12-09
Last Posted Date
2024-05-09
Lead Sponsor
The University of Texas Health Science Center, Houston
Target Recruit Count
50
Registration Number
NCT04659928
Locations
🇺🇸

The University of Texas Health Science Center at Houston, Houston, Texas, United States

KORTUC Phase II - Intra-tumoural Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer

Phase 2
Recruiting
Conditions
Breast Cancer
Interventions
First Posted Date
2019-05-10
Last Posted Date
2024-03-04
Lead Sponsor
Institute of Cancer Research, United Kingdom
Target Recruit Count
184
Registration Number
NCT03946202
Locations
🇮🇳

Regional Cancer Centre (RCC), Trivandrum, Kerala, India

🇮🇳

Tata Medical Centre, Kolkata, West Bengal, India

🇮🇳

Christian Medical Centre, Vellore, Tamil Nadu, India

and more 6 locations

Evaluation of Anti-biofilm Effects of Ferumoxytol (Feraheme) Using an in Situ Biofilm Demineralization Model

Early Phase 1
Completed
Conditions
Dental Caries
Interventions
Drug: Ferumoxytol/Hydrogen peroxide
Drug: Hydrogen Peroxide
Drug: Water
First Posted Date
2018-09-19
Last Posted Date
2018-09-19
Lead Sponsor
University of Pennsylvania
Target Recruit Count
16
Registration Number
NCT03678012
Locations
🇺🇸

Oral Health Research Institute, Indianapolis, Indiana, United States

🇺🇸

University of Pennsylvania, School of dental medicine, Philadelphia, Pennsylvania, United States

DMT310-001 Topical in the Treatment of Acne Vulgaris

Phase 2
Completed
Conditions
Acne Vulgaris
Interventions
Drug: DMT310
Drug: Hydrogen Peroxide
Drug: Placebo
First Posted Date
2018-05-25
Last Posted Date
2020-07-22
Lead Sponsor
Dermata Therapeutics
Target Recruit Count
121
Registration Number
NCT03536637
Locations
🇺🇸

Dermata Investigational Site, Katy, Texas, United States

Effects of Desensitizing Dentifrices on the Reduction of Pain Sensitivity Caused by In-office Dental Whitening

Phase 4
Completed
Conditions
Sensitivity
Tooth Whitening
Interventions
Procedure: Selection and preparation of the volunteers
Procedure: Evaluation of the tooth color
Procedure: Relative isolation
Procedure: Gingival protection barrier
Procedure: Application of desensitizing gel
Drug: Hydrogen peroxide
Procedure: Used a dentifrice
First Posted Date
2017-01-12
Last Posted Date
2017-01-12
Lead Sponsor
University of Campinas, Brazil
Target Recruit Count
4
Registration Number
NCT03019224

KORTUC: Intra-tumoural Hydrogen Peroxide as a Radiation Sensitizer in Patients With Locally Advanced/Recurrent Breast Cancer in Terms of Toxicity and Tumour Response

Phase 1
Completed
Conditions
Breast Cancer
Interventions
First Posted Date
2016-05-02
Last Posted Date
2020-11-27
Lead Sponsor
Institute of Cancer Research, United Kingdom
Target Recruit Count
12
Registration Number
NCT02757651
Locations
🇬🇧

The Royal Marsden NHS Foundation Trust, London, United Kingdom

Clinical Study to Evaluate of The Whitening Efficacy and Safety of REMEWHITE

Phase 3
Completed
Conditions
Tooth Whitening
Interventions
First Posted Date
2009-09-17
Last Posted Date
2009-09-17
Lead Sponsor
JDC Tech
Target Recruit Count
70
Registration Number
NCT00978861
Locations
🇰🇷

The cathiloc university of korea seoul st. mary's hospital, Seoul, Korea, Republic of

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