Bleomycin
- Generic Name
- Bleomycin
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C55H84N17O21S3
- CAS Number
- 11056-06-7
- Unique Ingredient Identifier
- 40S1VHN69B
- Background
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2 (B2 CAS # 9060-10-0). It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. Bleomycin A2 is used as the representative structure for Bleomycin.
- Indication
For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas.
- Associated Conditions
- Hodgkin's Lymphoma, Malignant Pleural Effusion, Non-Hodgkin's Lymphomas, Squamous Cell Carcinoma (SCC), Teratocarcinoma, Testicular Choriocarcinoma, Testicular Embryonal Carcinoma
- Associated Therapies
- Palliative Treatment
ECT STUDY High-grade or Initially Invasive Vulva - GinOnc-ECT Study
- First Posted Date
- 2024-12-04
- Last Posted Date
- 2024-12-04
- Target Recruit Count
- 18
- Registration Number
- NCT06715592
- Locations
- 🇮🇹
Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Lazio, Italy
GISEL:Registry of Breast Cancer Patients Treated With ECT
- Conditions
- Interventions
- First Posted Date
- 2024-11-11
- Last Posted Date
- 2024-11-11
- Lead Sponsor
- Istituto Oncologico Veneto IRCCS
- Target Recruit Count
- 205
- Registration Number
- NCT06683404
- Locations
- 🇮🇹
Veneto Institute of Oncology IRCCS, Padova, Italy
The Effect of Reduced Bleomycin in Electrochemotherapy Treatment
- Conditions
- Interventions
- First Posted Date
- 2024-10-17
- Last Posted Date
- 2024-10-17
- Lead Sponsor
- Julie Gehl
- Target Recruit Count
- 55
- Registration Number
- NCT06647342
- Locations
- 🇩🇰
Copenhagen University Hospital Herlev-Gentofte, Herlev, Denmark
🇩🇰Zealand University Hospital, Roskilde, Denmark
Use of Bleomycin in the Sclerotherapy of Lymphatic Malformations for Pediatric Patients
- First Posted Date
- 2024-05-31
- Last Posted Date
- 2024-06-03
- Lead Sponsor
- West China Hospital
- Target Recruit Count
- 200
- Registration Number
- NCT06437158
- Locations
- 🇨🇳
West China Hospital of Sichuan University, Chengdu, Sichuan, China
Treatment of Low-flow Venous Malformations With Electrosclerotherapy. Prospective Observational Study
- First Posted Date
- 2024-01-03
- Last Posted Date
- 2024-10-29
- Lead Sponsor
- Istituto Ortopedico Rizzoli
- Target Recruit Count
- 65
- Registration Number
- NCT06189092
- Locations
- 🇮🇹
Istituto Ortopedico Rizzoli, Bologna, Emilia Romagna, Italy
Electrochemotherapy With Carboplatinum Plus Bleomycin Versus Bleomycin Alone in Vulvar Cancer
- First Posted Date
- 2022-05-27
- Last Posted Date
- 2022-05-27
- Target Recruit Count
- 92
- Registration Number
- NCT05395962
- Locations
- 🇮🇹
IRCCS- Azienda Ospedaliera-Universitaria di Bologna, Bologna, Bo, Italy
Role of Propranolol as Compared to Bleomycin in Management of Hemangioma
- First Posted Date
- 2022-04-14
- Last Posted Date
- 2023-09-13
- Lead Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
- Target Recruit Count
- 90
- Registration Number
- NCT05327309
Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11)
- First Posted Date
- 2021-08-17
- Last Posted Date
- 2024-11-20
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 146
- Registration Number
- NCT05008224
- Locations
- 🇺🇸
Stanford Cancer Center ( Site 0023), Palo Alto, California, United States
🇺🇸Northwestern Memorial Hospital ( Site 0002), Chicago, Illinois, United States
🇺🇸Texas Oncology-Plano East ( Site 0020), Plano, Texas, United States
Brentuximab Vedotin in Early Stage Hodgkin Lymphoma
- First Posted Date
- 2020-12-28
- Last Posted Date
- 2024-10-30
- Lead Sponsor
- University College, London
- Target Recruit Count
- 1042
- Registration Number
- NCT04685616
- Locations
- 🇳🇱
Reinier de Graafweg 3-11 - Postbus 5011 - 2625 AD Delft, Delft, Netherlands
🇬🇧Colchester Hospital, ESNEFT, Colchester, United Kingdom
🇬🇧The Clatterbridge Cancer Centre NHSFT, 65 Pembroke Place, Liverpool, United Kingdom
First Line Chemotherapy for Classical Hodgkin Lymphoma in Russia (HL-Russia-1)
- First Posted Date
- 2020-11-20
- Last Posted Date
- 2022-11-01
- Target Recruit Count
- 300
- Registration Number
- NCT04638790
- Locations
- 🇮🇳
Tata Memorial Hospital, Mumbai, OPD-81 Main building, Dr. E Borges Road, Parel 400012, India
🇷🇺The Federal Budget-Funded Institution National Medical Surgical Center named after N. I. Pirogov of the Ministry of health of the Russian Federation, Moscow, Russian Federation
Drug Development Updates
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