Esomeprazole
- Generic Name
- Esomeprazole
- Brand Names
- Nexium, Vimovo, Nexium Control
- Drug Type
- Small Molecule
- Chemical Formula
- C17H19N3O3S
- CAS Number
- 119141-88-7
- Unique Ingredient Identifier
- N3PA6559FT
- Background
Esomeprazole, sold under the brand name Nexium, is a proton pump inhibitor (PPI) medication used for the management of gastroesophageal reflux disease (GERD), for gastric protection to prevent recurrence of stomach ulcers or gastric damage from chronic use of NSAIDs, and for the treatment of pathological hypersecretory conditions including Zollinger-Ellison ...
- Indication
Esomeprazole is indicated for the treatment of acid-reflux disorders including healing and maintenance of erosive esophagitis, and symptomatic gastroesophageal reflux disease (GERD), peptic ulcer disease, H. pylori eradication, prevention of gastrointestinal bleeds with NSAID use, and for the long-term treatment of pathological hypersecretory conditions incl...
- Associated Conditions
- Duodenal Ulcer, Erosive Esophagitis, Gastro-esophageal Reflux Disease (GERD), Heartburn, Helicobacter Pylori Infection, Stress Ulcers, Upper Gastrointestinal Hemorrhage, Zollinger-Ellison Syndrome, Acute benign gastric ulcers, Develop NSAID-induced gastric ulcers, Maintenance of healing Erosive esophagitis, Postendoscopy Bleeding
- Associated Therapies
- -
The Effect of Lifestyle-Adjustments Prior to Medical Treatment on the Effect of Medical Treatment in Reflux Patients
- Conditions
- First Posted Date
- 2007-09-03
- Last Posted Date
- 2008-09-17
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 990
- Registration Number
- NCT00524251
- Locations
- 🇳🇱
Research Site, Zoetermeer, Netherlands
Phase 1 Pharmacokinetics of Intravenous Nexium in Children
- First Posted Date
- 2007-05-16
- Last Posted Date
- 2010-12-03
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 42
- Registration Number
- NCT00474019
- Locations
- 🇸🇪
Research Site, Goteborg, Sweden
Compare Efficacy of Gastric Acid Suppression by Oral and Intravenous Administration of Esomeprazole in Patients With Peptic Ulcer
- Conditions
- First Posted Date
- 2007-05-09
- Last Posted Date
- 2007-05-09
- Lead Sponsor
- Pamela Youde Nethersole Eastern Hospital
- Target Recruit Count
- 20
- Registration Number
- NCT00471029
- Locations
- 🇨🇳
Pamela Youde Nethersole Eastern Hospital, Hong Kong, China
A Study to Compare the Number of Patients With Gastro-Oesophageal Reflux Disease (GORD) Achieving Heartburn and Regurgitation Symptom Resolution After Treatment With Either Rabeprazole Sodium 20mg, Esomeprazole 20mg or Esomeprazole 40mg
- First Posted Date
- 2007-04-23
- Last Posted Date
- 2014-04-21
- Lead Sponsor
- Janssen-Cilag Pty Ltd
- Target Recruit Count
- 1392
- Registration Number
- NCT00464308
Esomeprazole, Moxifloxacin and Amoxicilin for Rescue Therapy of Helicobacter Pylori Infection
- Conditions
- First Posted Date
- 2007-04-04
- Last Posted Date
- 2007-04-04
- Lead Sponsor
- Technische Universität Dresden
- Target Recruit Count
- 132
- Registration Number
- NCT00455806
- Locations
- 🇩🇪
Technical University of Munich, Medical Dept. II, Munich, Germany
🇩🇪Med. Department, Jung-Stilling Krankenhaus, Siegen, Germany
🇩🇪Med. Dept. I, Gastroenterology, University Hospital, Technical University of Dresden, Dresden, Germany
Esomeprazole Treatment for Patients With Lymphocytic Gastritis
- Conditions
- First Posted Date
- 2007-04-04
- Last Posted Date
- 2007-04-04
- Lead Sponsor
- Technische Universität Dresden
- Target Recruit Count
- 40
- Registration Number
- NCT00455754
- Locations
- 🇩🇪
Medical Department I, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany
Effect of Acid Reflux on Respiratory Physiology During Exercise in Athletes With GER-Response to Acid Suppression
- Conditions
- Interventions
- First Posted Date
- 2007-03-07
- Last Posted Date
- 2016-01-21
- Lead Sponsor
- University of Utah
- Target Recruit Count
- 31
- Registration Number
- NCT00444236
- Locations
- 🇺🇸
University of Utah Health Sciences Center, Salt Lake City, Utah, United States
Efficacy and Safety of Esomeprazole Once Daily for the Treatment of GERD in Neonatal Patients
- Conditions
- First Posted Date
- 2007-01-29
- Last Posted Date
- 2010-12-20
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 32
- Registration Number
- NCT00427635
- Locations
- 🇬🇧
Research Site, Sheffield, United Kingdom
Efficacy and Safety Study of Esomeprazole 20mg qd vs Ranitidine 150mg Bid in Patients With an NSAID-induced Gastric Ulcer
- Conditions
- First Posted Date
- 2006-11-22
- Last Posted Date
- 2010-07-08
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 397
- Registration Number
- NCT00401752
- Locations
- 🇭🇰
Research Site, Hong Kong, Hong Kong
Examine National Characteristics & Outcome Measures of GERD Patients Using the PPI Acid Suppression Symptom (PASS) Test for Response
- Conditions
- First Posted Date
- 2006-10-25
- Last Posted Date
- 2008-01-25
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 2000
- Registration Number
- NCT00392002
- Locations
- 🇨🇦
Research Site, Toronto, Ontario, Canada
Drug Development Updates
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