Leuprolide is a synthetic 9-residue peptide analogue of gonadotropin-releasing hormone (GnRH). Unlike the endogenous decapeptide GnRH, leuprolide contains a single D-amino acid (D-leucyl) residue, which helps to increase its circulating half-life from three to four minutes to approximately three hours. As a GnRH mimic, leuprolide is capable of binding to the...
Leuprolide is indicated for the treatment of advanced prostate cancer and as palliative treatment of advanced prostate cancer.
It is also used for the treatment of pediatric patients with central precocious puberty (CPP).
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Froedtert Hospital, Milwaukee, Wisconsin, United States
University Hospital Ulm Gynecology/Obstetrics, Ulm, Germany
ICO Paul Papin, Angers, France
ICO René Gauducheau, Saint-Herblain, France
Queensland Fertility Group, Brisbane, Queensland, Australia
Ouzid, Paris La Défense,, Paris, France
Tenon Hospital Paris France, Paris, France
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