Treosulfan
- Generic Name
- Treosulfan
- Brand Names
- Trecondi
- Drug Type
- Small Molecule
- Chemical Formula
- C6H14O8S2
- CAS Number
- 299-75-2
- Unique Ingredient Identifier
- CO61ER3EPI
- Background
Treosulfan is under investigation in Allogeneic Haematopoietic Stem Cell Transplantation. Treosulfan has been investigated for the treatment of Lymphoblastic Leukemia, Acute, Childhood.
- Indication
Not Available
- Associated Conditions
- -
- Associated Therapies
- HSCT conditioning therapy
Low Dose Treosulfan Based Conditioning Regimen and PTCy in HSCT for Nijmegen Breakage Syndrome
- First Posted Date
- 2024-01-10
- Last Posted Date
- 2024-01-10
- Target Recruit Count
- 10
- Registration Number
- NCT06198842
- Locations
- 🇷🇺
HSCT department, Moscow, Russian Federation
Clinical Trial Investigating the Chemotherapeutic Compound Treosulfan (Trecondi® Ideogen) in Myeloma Patients
- First Posted Date
- 2022-12-05
- Last Posted Date
- 2024-07-08
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 120
- Registration Number
- NCT05636787
- Locations
- 🇨ðŸ‡
Departement of Medical Oncology, University Hospital Berne, Berne, Switzerland
Effect of Moderate Renal Impairment and Race/Ethnicity on Treosulfan Pharmacokinetics
- Conditions
- Interventions
- First Posted Date
- 2022-09-09
- Last Posted Date
- 2024-02-21
- Lead Sponsor
- medac GmbH
- Target Recruit Count
- 36
- Registration Number
- NCT05534620
- Locations
- 🇺🇸
University of Illinois, Chicago, Illinois, United States
🇺🇸Memorial Sloan Kettering Cancer Center, New York, New York, United States
🇺🇸The Ohio State University, Columbus, Ohio, United States
Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia
- Conditions
- Interventions
- Drug: FludarabineDrug: ClofarabineProcedure: Hematopoietic Cell TransplantationRadiation: Total-Body IrradiationDrug: TreosulfanProcedure: EchocardiographyProcedure: Multigated Acquisition ScanProcedure: Lumbar PunctureProcedure: Bone Marrow AspirationProcedure: Bone Marrow BiopsyProcedure: Biospecimen Collection
- First Posted Date
- 2021-08-06
- Last Posted Date
- 2024-07-08
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 80
- Registration Number
- NCT04994808
- Locations
- 🇺🇸
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)
- Conditions
- Diamond-Blackfan AnemiaHereditary Sideroblastic AnemiaParoxysmal Nocturnal HemoglobinuriaShwachman-Diamond SyndromeHematologic Neoplasm With Germline GATA2 MutationHematologic Neoplasm With Germline SAMD9 MutationHematologic Neoplasm With Germline SAMD9L MutationBone Marrow Failure SyndromeCongenital Amegakaryocytic Thrombocytopenia
- Interventions
- Drug: TreosulfanDrug: Fludarabine PhosphateDrug: TacrolimusDrug: MethotrexateBiological: Lapine T-Lymphocyte Immune GlobulinProcedure: Peripheral Blood Stem Cell TransplantationProcedure: Allogeneic Bone Marrow TransplantationOther: Quality-of-Life AssessmentProcedure: EchocardiographyProcedure: Multigated Acquisition ScanProcedure: Bone Marrow BiopsyProcedure: Bone Marrow AspirationProcedure: Biospecimen CollectionProcedure: X-Ray ImagingProcedure: Computed Tomography
- First Posted Date
- 2021-07-16
- Last Posted Date
- 2024-06-17
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 40
- Registration Number
- NCT04965597
- Locations
- 🇺🇸
Oregon Health & Science University, Portland, Oregon, United States
🇺🇸Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
🇺🇸Cohen Children's Hospital of NY, Queens, New York, United States
Low Dose Treosulfan Based Conditioning Regimen in HSCT for Nijmegen Breakage Syndrome
- First Posted Date
- 2020-05-22
- Last Posted Date
- 2020-06-25
- Target Recruit Count
- 10
- Registration Number
- NCT04400045
- Locations
- 🇷🇺
HSCT department, Moscow, Russian Federation
Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies
- Conditions
- Interventions
- Procedure: Allogeneic Hematopoietic Stem Cell TransplantationDrug: CyclophosphamideDrug: CyclosporineBiological: FilgrastimDrug: FludarabineDrug: Mycophenolate MofetilDrug: Mycophenolate SodiumRadiation: Total-Body IrradiationDrug: TreosulfanProcedure: Bone Marrow AspirationProcedure: Bone Marrow BiopsyProcedure: EchocardiographyProcedure: Biospecimen CollectionProcedure: Computed TomographyProcedure: Positron Emission Tomography
- First Posted Date
- 2019-12-12
- Last Posted Date
- 2024-08-28
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 60
- Registration Number
- NCT04195633
- Locations
- 🇺🇸
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Thiotepa in Treating Patients With Non-malignant Disorders
- Conditions
- Interventions
- First Posted Date
- 2019-06-10
- Last Posted Date
- 2024-07-23
- Lead Sponsor
- Fred Hutchinson Cancer Center
- Target Recruit Count
- 40
- Registration Number
- NCT03980769
- Locations
- 🇺🇸
Fred Hutch/University of Washington Cancer Consortium, Seattle, Washington, United States
Phase II Trial in Elderly Patients With AML or MDS in Complete Remission Not Eligible for Allogenic Transplant
- First Posted Date
- 2019-05-23
- Last Posted Date
- 2023-11-18
- Lead Sponsor
- Ciceri Fabio
- Target Recruit Count
- 15
- Registration Number
- NCT03961919
- Locations
- 🇮🇹
Ospedale San Raffaele, Milano, Lombardia, Italy
A Trial With Metronomic Low-dose Treosulfan, Pioglitazone and Clarithromycin Versus Standard Treatment in NSCLC
- First Posted Date
- 2016-08-02
- Last Posted Date
- 2018-01-18
- Lead Sponsor
- University Hospital Regensburg
- Target Recruit Count
- 86
- Registration Number
- NCT02852083
- Locations
- 🇩🇪
MVZ am Klinikum GmbH, Passau, Bavaria, Germany
🇩🇪Klinik für Innere Medizin, Homburg/Saar, Saarland, Germany
🇩🇪St. Antonius-Hospital, Eschweiler, Nordrhein-Westfalen, Germany
Drug Development Updates
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