MedPath

Methylcellulose

Generic Name
Methylcellulose
Brand Names
Citrucel
Drug Type
Small Molecule
CAS Number
9004-67-5
Background

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values are 1.3 2.6. Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic

Indication

Solutions containing methyl cellulose are used as substitute for tears or saliva if the natural production of these fluids is disturbed. It is also used or constipation, diverticulosis, hemorrhoids and irritable bowel syndrome. Used in the manufacture of capsules in nutritional supplements. Its edible and nontoxic properties provide a vegetarian alternative to the use of gelatin.

Associated Conditions
Constipation, Dry Eye Syndrome (DES)
Associated Therapies
Eye disinfection

Effects of Topical Insulin on Corneal Epithelium Healing After Corneal Crosslinking in Patients With Keratoconus

Phase 3
Recruiting
Conditions
Keratoconus
Cornea Disease
Eye Diseases
Wound Heal
Interventions
First Posted Date
2024-09-19
Last Posted Date
2025-01-14
Lead Sponsor
University of Campinas, Brazil
Target Recruit Count
36
Registration Number
NCT06601101
Locations
🇧🇷

State University of Campinas, Campinas, São Paulo, Brazil

Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated with Radioactive Iodine for Thyroid Cancer

Phase 3
Recruiting
Conditions
Nasolacrimal Duct Obstruction
Thyroid Cancer
Interventions
First Posted Date
2023-08-21
Last Posted Date
2024-10-26
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
100
Registration Number
NCT05999630
Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Midodrine as Novel Treatment of Post-Cardiopulmonary Bypass Vasoplegic Syndrome

Phase 4
Terminated
Conditions
Use of Midodrine in Post-cardiopulmonary Bypass Vasoplegic Syndrome
Interventions
First Posted Date
2020-12-16
Last Posted Date
2022-07-01
Lead Sponsor
Medstar Health Research Institute
Target Recruit Count
10
Registration Number
NCT04668859

Effect of Topical Besifloxacin on Ocular Surface Bacterial Microbiota Prior to Cataract Surgery

Phase 1
Completed
Conditions
Cataract Senile
Microbial Disease
Interventions
First Posted Date
2020-09-09
Last Posted Date
2020-09-09
Lead Sponsor
Instituto de Oftalmología Fundación Conde de Valenciana
Target Recruit Count
60
Registration Number
NCT04542759
Locations
🇲🇽

Institute of Ophthalmology, Conde de Valenciana Foundation, Mexico, City, Mexico City, Mexico

Parasitic Ulcer Treatment Trial Pilot

Phase 2
Active, not recruiting
Conditions
Acanthamoeba Keratitis
Interventions
First Posted Date
2018-03-30
Last Posted Date
2024-02-06
Lead Sponsor
University of California, San Francisco
Target Recruit Count
49
Registration Number
NCT03484507
Locations
🇮🇳

Aravind Eye Hospital, Madurai, Tamil Nadu, India

Vitamin K to Attenuate Coronary Artery Calcification in Hemodialysis Patients

Phase 2
Completed
Conditions
End-stage Kidney Disease
Interventions
First Posted Date
2012-02-08
Last Posted Date
2021-06-28
Lead Sponsor
Dr. Rachel Holden
Target Recruit Count
85
Registration Number
NCT01528800
Locations
🇨🇦

The Ottawa Hospital, Ottawa, Ontario, Canada

🇨🇦

Kingston Health Sciences Centre: Kingston General Hospital Site, Kingston, Ontario, Canada

🇨🇦

London Health Sciences Centre, London, Ontario, Canada

Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial)

Phase 4
Completed
Conditions
Irritable Bowel Syndrome
Interventions
Drug: placebo
Behavioral: CBT website with minimal support
Behavioral: No website
Behavioral: CBT website with support
First Posted Date
2009-07-08
Last Posted Date
2021-04-30
Lead Sponsor
Hazel Everitt
Target Recruit Count
135
Registration Number
NCT00934973
Locations
🇬🇧

University of Southampton, Southampton, Hampshire, United Kingdom

Effect of Anti-inflammatory Topical Prednisolone, Nepafenac and Ketorolac in Intra-operative Mydriasis in Facetectomies

First Posted Date
2009-03-19
Last Posted Date
2011-05-24
Lead Sponsor
Clinica Oftamologica Zona Sul
Target Recruit Count
30
Registration Number
NCT00865540
Locations
🇧🇷

Clínica Oftalmológica Zona Sul, Recife, Pernambuco, Brazil

Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB)

Phase 1
Completed
Conditions
Multi-Drug Resistant Tuberculosis
Extensively Drug Resistant Tuberculosis
Interventions
First Posted Date
2008-06-05
Last Posted Date
2012-08-17
Lead Sponsor
Centers for Disease Control and Prevention
Target Recruit Count
26
Registration Number
NCT00691392
Locations
🇿🇦

King George V Hospital, Durban, KwaZulu Natal, South Africa

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