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Acitretin

Generic Name
Acitretin
Brand Names
Soriatane
Drug Type
Small Molecule
Chemical Formula
C21H26O3
CAS Number
55079-83-9
Unique Ingredient Identifier
LCH760E9T7
Background

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Indication

For the treatment of severe psoriasis in adults.

Associated Conditions
Keratinization disorders, Severe Psoriasis
Associated Therapies
-

Pilot Study on the Use of Acitretin for the Treatment of Severe Chronic Hand Dermatitis

Phase 2
Completed
Conditions
Chronic Hand Dermatitis
Interventions
First Posted Date
2012-03-06
Last Posted Date
2014-07-24
Lead Sponsor
Innovaderm Research Inc.
Target Recruit Count
9
Registration Number
NCT01545284
Locations
🇨🇦

Windsor Clinical Research Inc., Windsor, Ontario, Canada

🇨🇦

Innovaderm Research Inc., Montreal, Quebec, Canada

Study Evaluating the Efficacy and Safety of Triptergium Wilfordii and Acitretin in Psoriasis Vulgaris - CHINA201002016-2

Phase 4
Conditions
Psoriasis Vulgaris
Interventions
Drug: Triptergium Wilfordii
Drug: Acitretin
First Posted Date
2011-09-29
Last Posted Date
2011-09-29
Lead Sponsor
Ministry of Health, China
Target Recruit Count
720
Registration Number
NCT01443338
Locations
🇨🇳

Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China

Study of Acitretin to Treat Skin Rash Caused by Erlotinib (a Chemotherapy Drug)

Phase 4
Withdrawn
Conditions
Skin Rash
First Posted Date
2011-02-18
Last Posted Date
2013-01-16
Lead Sponsor
University of Pittsburgh
Registration Number
NCT01299220
Locations
🇺🇸

University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, United States

Alzheimer's Disease Acitretin Medication

Phase 2
Completed
Conditions
Alzheimer Disease
Interventions
Drug: Placebo
Drug: Acitretin
First Posted Date
2010-03-02
Last Posted Date
2018-02-05
Lead Sponsor
K. Lieb
Target Recruit Count
22
Registration Number
NCT01078168
Locations
🇩🇪

Department of psychiatry and psychotherapy, University medical center of the Johannes Gutenberg-University Mainz, Mainz, Rheinland-Pfalz, Germany

🇩🇪

Universität Rostock, Rostock, Germany

Dose Ranging Study to Assess the Efficacy and Safety of Acitretin in Severe Plaque Type Psoriasis

Phase 4
Completed
Conditions
Psoriasis
Interventions
First Posted Date
2009-12-24
Last Posted Date
2009-12-24
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
61
Registration Number
NCT01039142
Locations
🇮🇳

Post Graduate institute Of Medical Education and Research, Chandigarh, India

Study Evaluating the Efficacy and Safety of Etanercept and Acitretin in Korean Patient With Moderate to Severe Psoriasis

Phase 4
Completed
Conditions
Moderate to Severe Psoriasis
Interventions
First Posted Date
2009-07-09
Last Posted Date
2012-04-09
Lead Sponsor
Pfizer
Target Recruit Count
60
Registration Number
NCT00936065
Locations
🇰🇷

Pfizer Investigational Site, Seoul, Korea, Republic of

Evaluation of the Efficacy of Acitretin Therapy for Nail Psoriasis

Phase 4
Completed
Conditions
Psoriasis
First Posted Date
2008-07-28
Last Posted Date
2008-07-28
Lead Sponsor
Istituti Fisioterapici Ospitalieri
Target Recruit Count
36
Registration Number
NCT00723437
Locations
🇮🇹

Department of Dermatology University of Bologna, Bologna, Italy

Acitretin in Preventing Skin Cancer in Patients at High Risk for Skin Cancer

Not Applicable
Completed
Conditions
Non-melanomatous Skin Cancer
First Posted Date
2008-03-26
Last Posted Date
2011-05-16
Lead Sponsor
Mayo Clinic
Target Recruit Count
130
Registration Number
NCT00644384

Efficacy and Safety of Acitretin Plus Pioglitazone in Patients With Psoriasis

Phase 2
Completed
Conditions
Psoriasis
Interventions
First Posted Date
2006-11-06
Last Posted Date
2019-03-20
Lead Sponsor
Post Graduate Institute of Medical Education and Research, Chandigarh
Target Recruit Count
40
Registration Number
NCT00395941
Locations
🇮🇳

PGIMER, Chandigarh, India

Acitretin and Etanercept in Psoriasis

Phase 2
Completed
Conditions
Psoriasis
Interventions
First Posted Date
2005-09-12
Last Posted Date
2015-02-16
Lead Sponsor
University of Medicine and Dentistry of New Jersey
Target Recruit Count
10
Registration Number
NCT00156247
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