Mitomycins
- Generic Name
- Mitomycins
- Brand Names
- Jelmyto, Mitosol, Mutamycin
- Drug Type
- Small Molecule
- Chemical Formula
- C15H18N4O5
- CAS Number
- 50-07-7
- Unique Ingredient Identifier
- 50SG953SK6
- Background
Mitomycin is an antineoplastic antibiotic first isolated by Japanese microbiologists in the 1950s from cultures of Streptomyces caespitosus. It is an alkylating agent that inhibits DNA synthesis (and, at higher concentrations, RNA and protein synthesis) by cross-linking the complementary strands of the DNA double helix. Few other antibiotics have been discov...
- Indication
For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. Mitomycin is also indicated as a pyelocalyceal solution for the treatment of adults with low-grade upper tract urothelial cancer (LG-UTUC).
- Associated Conditions
- Anal Cancer, Bladder Cancer, Breast Cancer, Carcinoma of the Head and Neck, Cervical Cancer, Gastric Adenocarcinoma, Mesothelioma, Non-Small Cell Lung Cancer (NSCLC), Pancreatic Adenocarcinoma, Ab externo surgery Glaucoma, Low-grade Upper Tract Urothelial Cancer (LG-UTUC)
- Associated Therapies
- -
Mitomycin C With Hyperthermia and Intravesical Mitomycin C to Treat Recurrent Bladder Cancer
- Conditions
- Interventions
- First Posted Date
- 2008-08-14
- Last Posted Date
- 2015-06-29
- Lead Sponsor
- Mark Dewhirst
- Target Recruit Count
- 15
- Registration Number
- NCT00734994
- Locations
- 🇺🇸
Duke University Medical Center, Durham, North Carolina, United States
Primary Tube Versus Trabeculectomy Study
- Conditions
- Interventions
- First Posted Date
- 2008-04-24
- Last Posted Date
- 2022-10-19
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 242
- Registration Number
- NCT00666237
- Locations
- 🇺🇸
St. Louis University, Saint Louis, Missouri, United States
🇺🇸New York Eye and Ear Infirmary, New York, New York, United States
🇺🇸University of Virginia, Charlottesville, Virginia, United States
Use of Ranibizumab With Mitomycin C During Trabeculectomy
- First Posted Date
- 2008-04-18
- Last Posted Date
- 2016-10-13
- Lead Sponsor
- University of Colorado, Denver
- Target Recruit Count
- 30
- Registration Number
- NCT00661583
- Locations
- 🇺🇸
Rocky Mountain Lions Eye Institute, Aurora, Colorado, United States
Automated Lamellar Keratectomy in Symptomatic Patients With Bullous Keratopathy
- Conditions
- Interventions
- First Posted Date
- 2008-04-09
- Last Posted Date
- 2008-04-11
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 28
- Registration Number
- NCT00654888
Combination Chemotherapy, Radiation Therapy, and Sargramostim Before and After Surgery in Treating Patients With Soft Tissue Sarcoma That Can Be Removed By Surgery
- Conditions
- First Posted Date
- 2008-04-04
- Last Posted Date
- 2011-05-16
- Lead Sponsor
- Mayo Clinic
- Target Recruit Count
- 39
- Registration Number
- NCT00652860
Evaluation of Topical Mitomycin C as Adjuvant Drug to Esophageal Dilation in Children
- Conditions
- Interventions
- First Posted Date
- 2007-10-31
- Last Posted Date
- 2008-04-09
- Lead Sponsor
- Federal University of São Paulo
- Target Recruit Count
- 10
- Registration Number
- NCT00551824
- Locations
- 🇧🇷
Hospital São Paulo, São Paulo, SP, Brazil
Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer
- Conditions
- Interventions
- First Posted Date
- 2007-01-18
- Last Posted Date
- 2019-02-27
- Lead Sponsor
- Radiation Therapy Oncology Group
- Target Recruit Count
- 63
- Registration Number
- NCT00423293
- Locations
- 🇺🇸
St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States
🇺🇸Genesys Hurley Cancer Institute, Flint, Michigan, United States
🇺🇸Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States
Study of Mitomycin-C in Patients With Advanced or Recurrent Pancreatic Cancer With Mutated BRCA2 Gene
- Locations
- 🇺🇸
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Outcomes of Intraoperative 5-Fluorouracil Versus Mitomycin C
- Conditions
- First Posted Date
- 2006-06-30
- Last Posted Date
- 2007-12-27
- Lead Sponsor
- Indiana University School of Medicine
- Target Recruit Count
- 70
- Registration Number
- NCT00346489
- Locations
- 🇺🇸
University Hospital and Outpatient Center, Indianapolis, Indiana, United States
🇺🇸IU Eye at Carmel, Indianapolis, Indiana, United States
Safety Study of Recombinant Human Hyaluronidase (Chemophase) in Combination With Mitomycin in Participants With Superficial Bladder Cancer
- First Posted Date
- 2006-04-27
- Last Posted Date
- 2021-10-29
- Lead Sponsor
- Halozyme Therapeutics
- Target Recruit Count
- 27
- Registration Number
- NCT00318643
- Locations
- 🇺🇸
MedResearch, La Mesa, California, United States
🇺🇸Advanced Research Institute, New Port Richey, Florida, United States
🇺🇸BCG Oncology, Phoenix, Arizona, United States
Drug Development Updates
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