Heparin

Generic Name: Heparin

Brand Names: Heparin Leo

Drug Type: Small Molecule

Chemical Formula: -

CAS Number: 9005-49-6

Unique Ingredient Identifier: T2410KM04A

Background: Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (fac...

Indication: Unfractionated heparin is indicated for prophylaxis and treatment of venous thrombosis and its extension, prevention of post-operative deep venous thrombosis and pulmonary embolism and prevention of clotting in arterial and cardiac surgery. In cardiology, it is used to prevent embolisms in patients with atrial fibrillation and as an adjunct antithrombin ther...

Associated Conditions: Blunt Injury, Clotting, Coagulopathy, Consumption, Contusions, Deep vein thrombosis postoperative, Disseminated Intravascular Coagulation (DIC), External Hemorrhoid, Inflammation, Inflammatory, non-infectious pruritic dermatosis, Interstitial Cystitis, Post procedural pulmonary embolism, Pulmonary Embolism, ST Segment Elevation Myocardial Infarction (STEMI), Sprains, Thromboembolism, Unstable Angina Pectoris, Venous Thrombosis (Disorder), Hematomas, Peripheral arterial embolism, Thromboembolic phenomena, Varicosities of the great saphenous vein

Associated Therapies: Circulation, Extracorporeal, Dialysis therapy, Transfusions, Maintenance of patency of IV injection devices

Clinical Trials

Safety and Efficacy of Bivalirudin Versus Heparin for Systemic Anticoagulation in Extracorporeal Membrane Oxygenation

Phase 4

Conditions: Extracorporeal Membrane Oxygenation Complication
Anticoagulants

Interventions: Drug: Bivalirudin
Drug: Unfractionated heparin

First Posted Date: 2019-05-28

Last Posted Date: 2019-05-28

Lead Sponsor: Legacy Health System

Target Recruit Count: 34

Registration Number: NCT03965208

Locations: 🇺🇸
Legacy Health System, Portland, Oregon, United States

Papaverine vs Heparin for Peripheral Arterial Catheter Patency in Pediatric Patients

Phase 4

Completed

Conditions: Pediatrics
Anesthesia
Vasospasm

Interventions: Drug: Papaverine
Drug: Rescue papaverine, as needed
Drug: Heparin

First Posted Date: 2019-03-29

Last Posted Date: 2022-10-27

Lead Sponsor: The University of Texas Health Science Center, Houston

Target Recruit Count: 100

Registration Number: NCT03894904

Locations: 🇺🇸
UT Health, Houston, Texas, United States

Bivalirudin in Elderly Patients With Acute ST-segment Elevation Myocardial Infarction

Phase 4

Conditions: Aged
STEMI
Percutaneous Coronary Intervention

Interventions: Drug: Heparin
Drug: Bivalirudin

First Posted Date: 2019-03-20

Last Posted Date: 2019-03-20

Lead Sponsor: The First Affiliated Hospital of Dalian Medical University

Target Recruit Count: 240

Registration Number: NCT03882775

Locations: 🇨🇳
The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China

Study to Evaluate Safety and Efficacy of IBsolvMIR in Islet Transplantation

Phase 2

Terminated

Conditions: Diabetes Mellitus, Type 1

Interventions: Drug: IBsolvMIR
Drug: Heparin

First Posted Date: 2019-03-08

Last Posted Date: 2024-05-16

Lead Sponsor: TikoMed AB

Target Recruit Count: 7

Registration Number: NCT03867851

Locations: 🇳🇱
Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands
🇸🇪
Sahlgrenska sjukhuset, Göteborg, Sweden
🇸🇪
Akademiska sjukhuset, Uppsala, Sweden

and more 2 locations

Low Dose Catheter Directed Thrombolysis for Acute Pulmonary Embolism

Phase 2

Conditions: Pulmonary Embolism

Interventions: Drug: Low dose alteplase
Drug: Unfractionated heparin
Device: Infusion catheter

First Posted Date: 2019-02-26

Last Posted Date: 2021-04-28

Lead Sponsor: University of Aarhus

Target Recruit Count: 60

Registration Number: NCT03854266

Locations: 🇩🇰
Aarhus University Hospital, Dep. Cardiology, Aarhus N, Denmark

Bivalirudin With Prolonged Full Dose Infusion Versus Heparin Alone During Emergency PCI

Not Applicable

Conditions: ST Elevation Myocardial Infarction

Interventions: Drug: unfractionated Heparin
Drug: Bivalirudin

First Posted Date: 2019-01-30

Last Posted Date: 2022-06-13

Lead Sponsor: Shenyang Northern Hospital

Target Recruit Count: 6016

Registration Number: NCT03822975

Locations: 🇨🇳
Linquan County Peoples Hospital, Fuyang, Anhui, China
🇨🇳
Bengbu Second People's Hospital, Bengbu, Anhui, China
🇨🇳
Fu Yang People'S Hospital, Fuyang, Anhui, China

and more 82 locations