Hydrocortisone

Generic Name: Hydrocortisone

Brand Names: Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₅

CAS Number: 50-23-7

Unique Ingredient Identifier: WI4X0X7BPJ

Background: Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication: Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Corticosteroid Therapy in Refractory Shock Following Cardiac Arrest

Phase 1

Completed

Conditions: Cardiac Arrest

Interventions: Drug: Hydrocortisone
Drug: Normal Saline

First Posted Date: 2008-05-13

Last Posted Date: 2017-05-17

Lead Sponsor: Beth Israel Deaconess Medical Center

Target Recruit Count: 50

Registration Number: NCT00676585

Locations: 🇺🇸
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

Organ Donation and Hydrocortisone Treatment

Not Applicable

Terminated

Conditions: Brain Death

Interventions: Drug: hydrocortisone
Drug: sodium chloride

First Posted Date: 2008-05-09

Last Posted Date: 2015-04-06

Lead Sponsor: Kuopio University Hospital

Target Recruit Count: 38

Registration Number: NCT00675272

Locations: 🇫🇮
Kuopio University Hospital, Kuopio, Finland
🇫🇮
Tampere University Hospital, Tampere, Finland

Veteran Stress and Learning Study

Phase 4

Completed

Conditions: Stress Disorders, Posttraumatic

Interventions: Drug: Placebo
Drug: D-Cycloserine
Drug: Hydrocortisone

First Posted Date: 2008-05-08

Last Posted Date: 2019-05-30

Lead Sponsor: VA Office of Research and Development

Target Recruit Count: 111

Registration Number: NCT00674570

Locations: 🇺🇸
San Francisco VA Medical Center, San Francisco, CA, San Francisco, California, United States

Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression

Phase 1

Terminated

Conditions: Renin Angiotensin

Interventions: Drug: Fludrocortisone
Drug: Hydrocortisone
Drug: Placebo of Hydrocortisone
Drug: Placebo of Fludrocortisone

First Posted Date: 2008-05-07

Last Posted Date: 2012-03-02

Lead Sponsor: Rennes University Hospital

Target Recruit Count: 13

Registration Number: NCT00673270

Locations: 🇫🇷
Unité d'Investigation Clinique - Hôpital de Pontchaillou, Rennes, France

Hydrocortisone for Prevention of Septic Shock

Phase 3

Completed

Conditions: Severe Sepsis

Interventions: Drug: Hydrocortisone
Drug: Placebo

First Posted Date: 2008-05-01

Last Posted Date: 2013-09-27

Lead Sponsor: Charite University, Berlin, Germany

Target Recruit Count: 380

Registration Number: NCT00670254

Locations: 🇩🇪
Zentralklinik Bad Berka GmbH, Zentrum für Anaesthesie, Intensivtherapie und Notfallmedizin, Bad Berka, Germany
🇩🇪
HELIOS Klinikum Bad Saarow; Zentrum für Anaesthesiologie, Intensivmedizin, Notfallmedizin und Schmerztherapie, Bad Saarow, Germany
🇩🇪
Vivantes Klinikum Hellersdorf, Klinik fuer Anaesthesie, operative Intensivmedizin und Schmerztherapie, Berlin, Germany

and more 27 locations