Hydrocortisone

Generic Name
Hydrocortisone
Brand Names
Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody
Drug Type
Small Molecule
Chemical Formula
C21H30O5
CAS Number
50-23-7
Unique Ingredient Identifier
WI4X0X7BPJ
Background

Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication

Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions
Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
Associated Therapies
Palliative Treatment
Clinical Trials
Related News

Cortisol Control of Human Inflammatory Responses to Endotoxin

Not Applicable
Completed
Conditions
Sepsis
Interventions
Other: Çontrol
Drug: Hydrocortisone
First Posted Date
2006-11-06
Last Posted Date
2008-05-09
Lead Sponsor
Dartmouth-Hitchcock Medical Center
Target Recruit Count
36
Registration Number
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Locations
🇺🇸

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Hydrocortisone Versus Hydrocortisone Plus Fludrocortisone for the Treatment of Adrenal Insufficiency in Severe Sepsis

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Conditions
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Adrenal Insufficiency
Interventions
Drug: Hydrocortisone
First Posted Date
2006-08-24
Last Posted Date
2012-02-13
Lead Sponsor
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Registration Number
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Low-dose Cortisol in Chronic Posttraumatic Stress Disorder

Not Applicable
Terminated
Conditions
Posttraumatic Stress Disorder
First Posted Date
2006-08-10
Last Posted Date
2010-01-12
Lead Sponsor
University of Zurich
Target Recruit Count
20
Registration Number
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Locations
🇨🇭

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Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants

Phase 3
Completed
Conditions
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First Posted Date
2006-08-01
Last Posted Date
2011-04-12
Lead Sponsor
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40
Registration Number
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Locations
🇨🇦

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Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock

First Posted Date
2006-05-03
Last Posted Date
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Registration Number
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Locations
🇫🇷

Hôpital Jean Verdier, Bondy, France

🇫🇷

Hôpital central, Nancy, France

🇫🇷

Hôpital Avicenne, Bobigny, France

and more 5 locations

Effect of Estrogen & Stress for Postmenopausal Women

Phase 2
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Conditions
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First Posted Date
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Last Posted Date
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Registration Number
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Allogeneic Transplantation From Related Haploidentical Donors

First Posted Date
2005-09-16
Last Posted Date
2019-12-04
Lead Sponsor
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Target Recruit Count
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Registration Number
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Locations
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Phase 2 Trial of Prophylactic Rituximab Therapy for Prevention of CGVHD

First Posted Date
2005-09-16
Last Posted Date
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Lead Sponsor
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Registration Number
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Locations
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Trilostane for Androgen-Independent Prostate Cancer

Phase 2
Completed
Conditions
Prostate Cancer
Prostate Adenocarcinoma
First Posted Date
2005-09-16
Last Posted Date
2013-12-03
Lead Sponsor
Genzyme, a Sanofi Company
Target Recruit Count
24
Registration Number
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Locations
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Massachusetts General Hospital, Boston, Massachusetts, United States

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Dana-Farber Cancer Institute, Boston, Massachusetts, United States

Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response?

Not Applicable
Completed
Conditions
Depressive Disorder, Major
First Posted Date
2005-09-16
Last Posted Date
2019-10-04
Lead Sponsor
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Target Recruit Count
18
Registration Number
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Locations
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Stanford University School of Medicine, Stanford, California, United States

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