Hydrocortisone

Generic Name: Hydrocortisone

Brand Names: Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody

Drug Type: Small Molecule

Chemical Formula: C_₂₁H_₃₀O_₅

CAS Number: 50-23-7

Unique Ingredient Identifier: WI4X0X7BPJ

Background: Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.

Hydrocortisone was granted FDA approval on 5 August 1952.

Indication: Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...

Associated Conditions: Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

Associated Therapies: Palliative Treatment

Clinical Trials

Treatment of Mature B-ALL and Burkitt Lymphoma (BL) in Adult Patients. BURKIMAB-14.

Phase 2

Conditions: Mature B-Cell Leukemia Burkitt Type
Burkitt Lymphoma (BL)
Unclassifiable Lymphoma Between DCBL and BL

Interventions: Drug: Rituximab
Drug: Methotrexate
Drug: Dexamethasone
Drug: Iphosphamid
Drug: Vincristine
Drug: Etoposide
Drug: Cytarabine
Drug: Cyclophosphamide
Drug: Doxorubicin
Drug: Vindesine
Drug: Hydrocortisone
Drug: Prednisone

First Posted Date: 2021-09-20

Last Posted Date: 2021-09-20

Lead Sponsor: PETHEMA Foundation

Target Recruit Count: 100

Registration Number: NCT05049473

Locations: 🇪🇸
Hospital Germans Trias i Pujol, Badalona, Barcelona, Spain
🇪🇸
Hospital del Mar, Barcelona, Spain
🇪🇸
ICO-Hospital Duran i Reynals, Bellvitge, Spain

and more 26 locations

Imaging CRF X NOP Interactions in CUD

Early Phase 1

Recruiting

Conditions: Cocaine Use Disorder

Interventions: Radiation: Baseline [C-11]NOP-1A PET Scan
Drug: Hydrocortisone
Radiation: Post-hydrocortisone [C-11]NOP-1A PET Scan

First Posted Date: 2021-08-17

Last Posted Date: 2024-12-13

Lead Sponsor: Rajesh Narendran

Target Recruit Count: 80

Registration Number: NCT05008146

Locations: 🇺🇸
University of Pittsburgh, Pittsburgh, Pennsylvania, United States

PTSD Prevention Using Oral Hydrocortisone

Phase 2

Recruiting

Conditions: PTSD
Acute Stress Disorder
Trauma-related Stressor

Interventions: Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2021-06-11

Last Posted Date: 2024-04-25

Lead Sponsor: Rachel Yehuda

Target Recruit Count: 220

Registration Number: NCT04924166

Locations: 🇮🇱
The Chaim Sheba Medical Center, Ramat Gan, Israel
🇺🇸
Mount Sinai Morningside Emergency Department, New York, New York, United States
🇺🇸
Icahn School of Medicine at Mount Sinai, New York, New York, United States

Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study Hydrocortisone Treatment for Symmetric Lipomatosis Associated With Neuropathy (SLN): an N-of-1 Study

Phase 3

Conditions: Symmetric Lipomatoses, Multiple

Interventions: Drug: Placebo
Drug: Hydrocortisone

First Posted Date: 2021-03-29

Last Posted Date: 2021-03-29

Lead Sponsor: Erasmus Medical Center

Target Recruit Count: 1

Registration Number: NCT04821583

Locations: 🇳🇱
Erasmus MC, Rotterdam, Zuid-Holland, Netherlands

Hydrocortisone Use During Peri-operation for Pituitary Adenomas

Not Applicable

Conditions: Adrenal Insufficiency
Surgery
Pituitary Adenoma

Interventions: Drug: Normal saline
Drug: Hydrocortisone

First Posted Date: 2020-11-09

Last Posted Date: 2020-11-09

Lead Sponsor: Peking Union Medical College Hospital

Target Recruit Count: 436

Registration Number: NCT04621565

Locations: 🇨🇳
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, Beijing, China