Hydroxyethyl Starch

Generic Name: Hydroxyethyl Starch

Brand Names: Hespan, Hextend, Volulyte, Voluven

Drug Type: Small Molecule

CAS Number: 9005-27-0

Unique Ingredient Identifier: 875Y4127EA

Background: Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.

HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.

Indication: An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.

Associated Conditions: Hypovolaemia

Associated Therapies: Granulocyte yield increase

Clinical Trials

Safety and Efficacy of Perioperative Volume Replacement with Volulyte 6% in Moderate-to-high Cardiovascular Risk Patients Having Major Abdominal Surgery

Phase 4

Not yet recruiting

Conditions: Perioperative Volume Replacement
Hydroxyethyl Starch

Interventions: Drug: Hydroxyethyl starch 130/0.4
Drug: Sodium acetate Ringer

First Posted Date: 2024-10-29

Last Posted Date: 2024-10-29

Lead Sponsor: Xiangya Hospital of Central South University

Target Recruit Count: 410

Registration Number: NCT06663254

Locations: 🇨🇳
The First Affiliated Hospital of Zhengzhou University;, Zhengzhou, Henan, China
🇨🇳
Xiangya Hospital of Central South University, Changsha, Hunan, China
🇨🇳
The First Hospital of China Medical University, Shenyang, Liaoning, China

and more 3 locations

Comparison of Hydroxyethyl Starch and Crystalloid Coload Combined With Norepinephrine Infusion for Hypotension

Not Applicable

Completed

Conditions: Adverse Effect

Interventions: Drug: Crystalloid
Drug: Hydroxyethyl starch

First Posted Date: 2022-07-27

Last Posted Date: 2023-03-22

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 80

Registration Number: NCT05475990

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

6% Hydroxyethyl Starch (130/0.4) Coload for Postspinal Anesthesia Hypotension

Not Applicable

Recruiting

Conditions: Adverse Effect

Interventions: Drug: Hydroxyethyl starch 130/0.4

First Posted Date: 2022-07-27

Last Posted Date: 2024-02-02

Lead Sponsor: General Hospital of Ningxia Medical University

Target Recruit Count: 40

Registration Number: NCT05475886

Locations: 🇨🇳
General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China

Days Alive and Out of Hospital for Patients With Sepsis

Completed

Conditions: Sepsis
Septic Shock

Interventions: Drug: Hydroxyethyl starch
Procedure: Early Goal Directed Therapy
Drug: Hydrocortisone

First Posted Date: 2020-09-28

Last Posted Date: 2024-02-23

Lead Sponsor: The George Institute for Global Health, Australia

Target Recruit Count: 6213

Registration Number: NCT04567433

Locations: 🇦🇺
Division of Critical Care, The George Institute for Global Health, Newtown, New South Wales, Australia

Restrictive or Doppler-guided Fluid Treatment in Colorectal Surgery

Not Applicable

Completed

Conditions: Fluid Overload

Interventions: Drug: Voluven to near maximal stroke volume of the heart

First Posted Date: 2018-09-19

Last Posted Date: 2018-10-05

Lead Sponsor: Holbaek Sygehus

Target Recruit Count: 150

Registration Number: NCT03677622

Different Preloads for Prevention of Hypotension in Patients Undergoing Elective CS Under Intrathecal Anesthesia

Early Phase 1

Conditions: Hypotension Drug-Induced

Interventions: Drug: Ringer
Drug: Voluven

First Posted Date: 2018-03-15

Last Posted Date: 2018-03-15

Lead Sponsor: Assiut University

Target Recruit Count: 60

Registration Number: NCT03465943

A Comparison of Eleview Versus Hetastarch as Injectate for EMR

Phase 4

Completed

Conditions: Delayed Bleeding
Procedural Bleeding
Post-Polypectomy Syndrome
Post Procedural Complication

Interventions: Drug: Eleview
Drug: Hetastarch

First Posted Date: 2017-11-22

Last Posted Date: 2019-12-17

Lead Sponsor: Indiana University

Target Recruit Count: 160

Registration Number: NCT03350217

Locations: 🇺🇸
Indiana University, Indianapolis, Indiana, United States

Safety and Efficacy of a 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Trauma Patients

Phase 4

Completed

Conditions: Hypovolemia Due to Acute Blood Loss

Interventions: Drug: Volulyte 6%
Drug: Ionolyte

First Posted Date: 2017-11-09

Last Posted Date: 2022-08-05

Lead Sponsor: Fresenius Kabi

Target Recruit Count: 238

Registration Number: NCT03338218

Locations: 🇫🇷
CHRU Nancy - Hôpital Central, Nancy, France
🇿🇦
FCRN Clinical Trials Centre, Vereeniging, South Africa
🇪🇸
Hospital Clinico Universitario, Valencia, Spain

and more 19 locations

Comparing Human Albumin Versus Hydroxyethylstarch in Renal Transplant Recipients

Not Applicable

Completed

Conditions: Anesthesia Morbidity

Interventions: Other: Albumin resuscitation
Other: Hydroxyethylstarch resuscitation
Drug: Albumin 5%
Drug: Hydroxyethylstarch 6%

First Posted Date: 2017-10-11

Last Posted Date: 2020-01-28

Lead Sponsor: Cairo University

Target Recruit Count: 120

Registration Number: NCT03306914

Locations: 🇪🇬
Cairo University, Cairo, Egypt

Safety and Efficacy of 6% Hydroxyethyl Starch (HES) Solution Versus an Electrolyte Solution in Patients Undergoing Elective Abdominal Surgery

Phase 4

Completed

Conditions: Hypovolaemia Due to Acute Blood Loss

Interventions: Drug: Volulyte 6%
Drug: Ionolyte

First Posted Date: 2017-09-11

Last Posted Date: 2024-01-31

Lead Sponsor: Fresenius Kabi

Target Recruit Count: 2289

Registration Number: NCT03278548

Locations: 🇵🇱
Klinika Wiśniowa, Zielona Góra, Poland
🇦🇹
Social Medical Center East - Donauspital, Vienna, Austria
🇵🇱
Medical University of Lublin, Lublin, Poland

and more 58 locations

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