Hydroxyethyl Starch
- Generic Name
- Hydroxyethyl Starch
- Brand Names
- Hespan, Hextend, Volulyte, Voluven
- Drug Type
- Small Molecule
- CAS Number
- 9005-27-0
- Unique Ingredient Identifier
- 875Y4127EA
- Background
Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.
HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.
- Indication
An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.
- Associated Conditions
- Hypovolaemia
- Associated Therapies
- Granulocyte yield increase
Pilot Study of Hemospan® in Patients With Chronic Critical Limb Ischemia
- Conditions
- Vascular DiseaseCritical Lower Limb Ischemia
- Interventions
- Drug: Hemospan (MP4OX)
- First Posted Date
- 2008-03-12
- Last Posted Date
- 2013-08-19
- Lead Sponsor
- Sangart
- Target Recruit Count
- 6
- Registration Number
- NCT00633659
- Locations
- 🇸🇪
Karolinska Universitetssjukhuset, Stockholm, Sweden
Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty
- Conditions
- Hip Replacement Arthroplasty
- Interventions
- Drug: Ringer's lactate
- First Posted Date
- 2007-10-11
- Last Posted Date
- 2009-02-19
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 48
- Registration Number
- NCT00542516
- Locations
- 🇧🇷
Institute of Orthopedics and Traumatology of HCFMUSP, São Paulo, Brazil
Crystalloids Versus Colloids During Surgery
- Conditions
- Fluid OverloadPostoperative Complications
- Interventions
- Drug: Lactated Ringer's Solution
- First Posted Date
- 2007-08-16
- Last Posted Date
- 2018-01-10
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 1109
- Registration Number
- NCT00517127
- Locations
- 🇦🇹
Medical University of Vienna, Vienna, Austria
An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy
- Conditions
- Crohn's DiseaseUlcerative ColitisRectal CancerColon CancerColon PolypsRectal PolypsDiverticulitis
- First Posted Date
- 2007-05-01
- Last Posted Date
- 2009-10-21
- Lead Sponsor
- Spectrum Health Hospitals
- Target Recruit Count
- 69
- Registration Number
- NCT00467922
- Locations
- 🇺🇸
Spectrum Health, Grand Rapids, Michigan, United States
Effects of Voluven on Hemodynamics and Tolerability of Enteral Nutrition in Patients With Severe Sepsis
- Conditions
- Sepsis
- Interventions
- Drug: 0.9 % NaCl
- First Posted Date
- 2007-04-23
- Last Posted Date
- 2012-01-11
- Lead Sponsor
- Fresenius Kabi
- Target Recruit Count
- 196
- Registration Number
- NCT00464204
- Locations
- 🇫🇷
CHU de Dijon - Hôpital du Bocage Service de Réanimation Médicale, Dijon, France
🇫🇷Hôpital Lapeyronie / CHU Montpellier, Département d'Anesthésie Réanimation, Montpellier, France
🇫🇷Hôpital Central, Service Anesthésie-Réanimation, Chirurgicale CHU, Nancy, France
Stroke Volume Optimisation in Patients With Hip Fracture
- Conditions
- Hip Fractures
- Interventions
- Procedure: hemodynamic optimisation guided using esophageal Doppler
- First Posted Date
- 2007-03-07
- Last Posted Date
- 2011-10-07
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 215
- Registration Number
- NCT00444262
- Locations
- 🇫🇷
Centre Hospitalier Universitaire de La Cote de Nacre, Caen, Calvados, France
🇫🇷Centre Hospitalier Universitaire de Poitiers, Poitiers, Vienne, France
🇫🇷Hopital La Pitie Salpetriere, Paris, France
Fluid Infusion During Breast Surgery
- Conditions
- Breast Surgery
- First Posted Date
- 2007-02-06
- Last Posted Date
- 2009-03-03
- Lead Sponsor
- Rigshospitalet, Denmark
- Target Recruit Count
- 32
- Registration Number
- NCT00431743
- Locations
- 🇩🇰
Dept of anesthesia 2041, ABD centre, Rigshospitalet, Blegdamsvej, Copenhagen, Seeland, Denmark
Phase III Study of Hemospan® to Prevent Hypotension in Hip Arthroplasty
- Conditions
- HypotensionIschemia
- Interventions
- Drug: Hemospan (MP4OX)
- First Posted Date
- 2007-01-11
- Last Posted Date
- 2013-08-19
- Lead Sponsor
- Sangart
- Target Recruit Count
- 375
- Registration Number
- NCT00421200
- Locations
- 🇸🇪
S:t Görans Hospital, Stockholm, Sweden
🇬🇧Univ. Hospital - Queen's Medical Center, Nottingham, United Kingdom
🇸🇪Skaraborg Hospital, Skövde, Sweden
Phase III Study of Hemospan® for Treating Hypotension in Hip Arthroplasty
- Conditions
- HypotensionIschemia
- Interventions
- Drug: Hemospan (MP4OX)
- First Posted Date
- 2007-01-11
- Last Posted Date
- 2013-08-19
- Lead Sponsor
- Sangart
- Target Recruit Count
- 462
- Registration Number
- NCT00420277
- Locations
- 🇧🇪
Stedelijk Ziekenhuis Roeselare, Roeselare, Belgium
🇨🇿Fakultni nemocnice Motol, I. Ortopedicka klinika, Prague, Czech Republic
🇸🇪Länssjukhuset Gävle, Gävle, Sweden
Pilot Study of Hemoglobin Based Oxygen Therapeutics in Elective Coronary Revascularization
- Conditions
- Angina PectorisUnstable AnginaMyocardial Infarction
- Interventions
- Procedure: Percutaneous Coronary RevascularizationDrug: Hemoglobin-Based Oxygen Carrier-201 (HBOC-201)
- First Posted Date
- 2006-04-25
- Last Posted Date
- 2008-05-16
- Lead Sponsor
- Biopure Corporation
- Target Recruit Count
- 45
- Registration Number
- NCT00317512
- Locations
- 🇧🇪
Site # 6 Antwerpen, Antwerpen, Belgium
🇩🇪Site # 2 Herzzentrum, Leipzig, Germany
🇧🇪Site # 5 Onze Lieve Vrouw Ziekenhuis (OLVZ), Aalst, Belgium
Drug Development Updates
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