Hydroxyethyl Starch

Generic Name: Hydroxyethyl Starch

Brand Names: Hespan, Hextend, Volulyte, Voluven

Drug Type: Small Molecule

Chemical Formula: -

CAS Number: 9005-27-0

Unique Ingredient Identifier: 875Y4127EA

Background: Hydroxyethyl starch (HES/HAES) is a nonionic starch derivative. Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation to replace intravascular volume.

HES is a general term and can be sub-classified according to average molecular weight, molar substitution, concentration, C2/C6 ratio and Maximum Daily Dose.

Indication: An intravenous solution of hydroxyethyl starch is used to prevent shock following severe blood loss caused by trauma, surgery, or other issues.

Associated Conditions: Hypovolaemia

Associated Therapies: Granulocyte yield increase

Clinical Trials

The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies

Phase 4

Completed

Conditions: Subarachnoid Hemorrhage

Interventions: Drug: Lactated Ringer's solution
Drug: Hydroxyethyl starch

First Posted Date: 2014-02-17

Last Posted Date: 2014-02-17

Lead Sponsor: University of Debrecen

Target Recruit Count: 96

Registration Number: NCT02064075

Locations: 🇭🇺
University of Debrecen Medical and Health Science Center Department of Anesthesiology and Intensive Care, Debrecen, Hungary

Effect of Colloid Versus Crystalloid on Coagulation in Elective Urological Surgery

Phase 4

Completed

Conditions: Disorders of Coagulation

Interventions: Drug: Lactated Ringer
Drug: Hydroxyethylstarch

First Posted Date: 2013-12-11

Last Posted Date: 2013-12-11

Lead Sponsor: K. C. Rasmussen

Target Recruit Count: 40

Registration Number: NCT02009033

Effects of Colloid and Crystalloid on the Microcirculatory Alterations During Off-pump Coronary Artery Bypass Surgery

Not Applicable

Completed

Conditions: Cardiac Surgery

Interventions: Drug: plasmalyte solution
Drug: Hextend

First Posted Date: 2012-10-24

Last Posted Date: 2016-06-16

Lead Sponsor: Seoul National University Hospital

Target Recruit Count: 120

Registration Number: NCT01713166

Locations: 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of

Fluid Resuscitation in Patients Suffering From Burns Injury

Phase 4

Terminated

Conditions: Burns

Interventions: Drug: Volulyte
Drug: Human Serum Albumin

First Posted Date: 2012-09-21

Last Posted Date: 2014-06-26

Lead Sponsor: Fresenius Kabi

Target Recruit Count: 11

Registration Number: NCT01689506

Locations: 🇬🇧
University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Queen Elizabeth Medical Centre, Birmingham, United Kingdom

Cabergoline and Hydroxyethyl Starch in Ovarian Hyperstimulation Syndrome Prevention

Early Phase 1

Completed

Conditions: Complications Associated With Artificial Fertilization
Disorder of Endocrine Ovary

Interventions: Drug: Cabergoline and Hydroxyethyl Starch
Drug: Hydroxyethyl Starch

First Posted Date: 2012-02-10

Last Posted Date: 2012-02-10

Lead Sponsor: Hospital de Cruces

Target Recruit Count: 80

Registration Number: NCT01530490

Liberal Versus Restrictive Transfusion During Symptomatic Moderate Anemia After Hip Arthroplasty

Not Applicable

Terminated

Conditions: Arthroplasty, Hip

Interventions: Other: Red blood cell transfusion
Drug: Voluven

First Posted Date: 2011-10-17

Last Posted Date: 2015-03-06

Lead Sponsor: Rigshospitalet, Denmark

Target Recruit Count: 5

Registration Number: NCT01452581

Locations: 🇩🇰
Gentofte Hospital, Department of orthopedic surgery, Gentofte, Denmark
🇩🇰
Vejle Sygehus, Department of orthopedic surgery, Vejle, Denmark

Use of Hextend in Trauma

Completed

Conditions: Trauma

Interventions: Drug: Hextend

First Posted Date: 2009-09-24

Last Posted Date: 2017-06-14

Lead Sponsor: University of Miami

Target Recruit Count: 1714

Registration Number: NCT00983281

Locations: 🇺🇸
University of Miami, Miami, Florida, United States

Effect of Prime Solution on Fluid Balance After Open Heart Surgery

Phase 4

Completed

Conditions: Valve Surgery
Coronary Artery Bypass Grafting

Interventions: Drug: Ringer lactate
Drug: HES

First Posted Date: 2008-11-25

Last Posted Date: 2015-08-25

Lead Sponsor: University of Helsinki

Target Recruit Count: 35

Registration Number: NCT00797589

Locations: 🇫🇮
Helsinki University Central Hospital, Helsinki, Finland

Comparison Between Two Techniques of Volemic Expansion in Hip Replacement Arthroplasty

Phase 4

Completed

Conditions: Hip Replacement Arthroplasty

Interventions: Drug: Hydroxyethyl Starch
Drug: Ringer's lactate

First Posted Date: 2007-10-11

Last Posted Date: 2009-02-19

Lead Sponsor: University of Sao Paulo

Target Recruit Count: 48

Registration Number: NCT00542516

Locations: 🇧🇷
Institute of Orthopedics and Traumatology of HCFMUSP, São Paulo, Brazil

An Assessment of Goal-Directed Intraoperative Fluid Management in Hand Assisted Laparoscopic Colectomy

Phase 3

Completed

Conditions: Crohn's Disease
Ulcerative Colitis
Rectal Cancer
Colon Cancer
Colon Polyps
Rectal Polyps
Diverticulitis

First Posted Date: 2007-05-01

Last Posted Date: 2009-10-21

Lead Sponsor: Spectrum Health Hospitals

Target Recruit Count: 69

Registration Number: NCT00467922

Locations: 🇺🇸
Spectrum Health, Grand Rapids, Michigan, United States

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