Hydrocortisone
- Generic Name
- Hydrocortisone
- Brand Names
- Ala-cort, Ala-scalp, Alcortin, Alkindi, Anusol HC, Aquanil HC, Casporyn HC, Cipro, Cipro HC, Colocort, Cortaid, Cortane-B, Cortef, Cortenema, Cortisporin, Cortizone-10, Dermacort, Dermarest Eczema, Dermazene, Home Papkit, Hydroskin, Monistat Itch Relief, Neosporin Eczema, Preparation H Hydrocortisone, Procto-med, Procto-pak, Proctocort, Proctol, Proctosedyl, Proctosol, Proctozone HC, Scalpicin Itch Relief, Texacort, Vanoxide-HC, Xerese, Plenadren, Efmody
- Drug Type
- Small Molecule
- Chemical Formula
- C21H30O5
- CAS Number
- 50-23-7
- Unique Ingredient Identifier
- WI4X0X7BPJ
- Background
Hydrocortisone, or cortisol, is a glucocorticoid secreted by the adrenal cortex. Hydrocortisone is used to treat immune, inflammatory, and neoplastic conditions. It was discovered in the 1930s by Edward Kendall and named Compound F, or 17-hydroxycorticosterone.
Hydrocortisone was granted FDA approval on 5 August 1952.
- Indication
Otic solutions are indicated for infections of the external auditory canal caused by susceptible organisms and with inflammation. Hydrocortisone tablets are indicated for certain endocrine, rheumatic, collagen, allergic, ophthalmic, respiratory, hematologic, neoplastic, edematous, gastrointestinal, and other conditions. A hydrocortisone enema is indicated fo...
- Associated Conditions
- Acute Gouty Arthritis, Acute Leukemia, Acute Otitis Externa, Adrenal Insufficiency, Allergic Conjunctivitis (AC), Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Ankylosing Spondylitis (AS), Aspiration Pneumonitis, Asthma, Atopic Dermatitis, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Choroiditis, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Contact Dermatitis, Crohn's Disease (CD), Dermatitis, Dermatomyositis (DM), Dermatosis, Drug hypersensitivity reaction, Epicondylitis, Erythroblastopenia, Fissure;Anal, Haemorrhoids, Herpes Labialis, Hypercalcemia of Malignancy, Immune Thrombocytopenia (ITP), Infection of the Fenestration Cavity, Infection of the Mastoidectomy Cavity, Iridocyclitis, Iritis, Itching caused by Hemorrhoids, Itching of the Anus, Keratitis, Leukemias, Loeffler's syndrome, Lymphoma, Lymphomas NEC, Mycosis Fungoides (MF), Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Hemorrhoids, Pemphigus, Posterior Uveitis, Posttraumatic Osteoarthritis, Primary adrenocortical insufficiency, Proctitis, Proteinuria, Pruritis of the skin, Psoriatic Arthritis, Rectal inflammations NEC, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Skin Diseases, Stevens-Johnson Syndrome, Synovitis, Systemic Lupus Erythematosus, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Acute rheumatic carditis, Anterior eye segment inflammation, Cryptitis, Disseminated Pulmonary Tuberculosis (TB), Exfoliative erythroderma, Fulminating Pulmonary Tuberculosis, Non-suppurative Thyroiditis, Severe Erythema multiforme, Severe Psoriasis, Subacute Bursitis, Superficial infection of the external auditory canal with inflammation, Symptomatic Sarcoidosis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis
- Associated Therapies
- Palliative Treatment
Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With Coronavirus Disease (COVID-19)
- First Posted Date
- 2020-07-02
- Last Posted Date
- 2023-05-06
- Lead Sponsor
- Mesoblast International Sàrl
- Registration Number
- NCT04456439
Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia
- First Posted Date
- 2020-04-24
- Last Posted Date
- 2021-05-12
- Lead Sponsor
- University Hospital, Tours
- Registration Number
- NCT04359511
Hydrocortisone for COVID-19 and Severe Hypoxia
- Conditions
- Interventions
- First Posted Date
- 2020-04-16
- Last Posted Date
- 2021-09-21
- Lead Sponsor
- Scandinavian Critical Care Trials Group
- Target Recruit Count
- 30
- Registration Number
- NCT04348305
- Locations
- 🇩🇰
Aarhus University Hospital - Dept of Intensive care, Aarhus, Denmark
🇩🇰Rigshospitalet, Copenhagen, Denmark
🇩🇰Herlev Hospital - Dept. of Intensive Care, Herlev, Denmark
Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis
- Conditions
- Interventions
- First Posted Date
- 2019-12-12
- Last Posted Date
- 2020-10-19
- Lead Sponsor
- IMSS Hospital General de Zona 11, Piedras Negras
- Target Recruit Count
- 19
- Registration Number
- NCT04197115
- Locations
- 🇲🇽
Hospital General Zona 11 Imss Piedras Negras Coahuila, Piedras Negras, Coahuila, Mexico
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
- Conditions
- Interventions
- First Posted Date
- 2019-09-09
- Last Posted Date
- 2024-08-22
- Lead Sponsor
- Hospital for Special Surgery, New York
- Target Recruit Count
- 132
- Registration Number
- NCT04082533
- Locations
- 🇺🇸
Hospital for Special Surgery, New York, New York, United States
Safety and Efficacy of Prednisolone in Adrenal Insufficiency Disease (PRED-AID Study)
- Conditions
- Interventions
- First Posted Date
- 2019-05-03
- Last Posted Date
- 2023-09-01
- Lead Sponsor
- Imperial College London
- Target Recruit Count
- 44
- Registration Number
- NCT03936517
- Locations
- 🇬🇧
Imperial College Healthcare NHS Trust, London, United Kingdom
Inotuzumab Ozogamicin for Children With MRD Positive CD22+ Lymphoblastic Leukemia
- First Posted Date
- 2019-04-12
- Last Posted Date
- 2024-08-19
- Lead Sponsor
- St. Jude Children's Research Hospital
- Target Recruit Count
- 32
- Registration Number
- NCT03913559
- Locations
- 🇺🇸
Rady Children's Hospital San Diego, San Diego, California, United States
🇺🇸St. Jude Children's Research Hospital, Memphis, Tennessee, United States
Pregabalin Versus Hydrocortisone for Postdural Puncture Headache After Spinal for Cesarean
- Conditions
- Interventions
- First Posted Date
- 2019-04-10
- Last Posted Date
- 2019-11-12
- Lead Sponsor
- Cairo University
- Target Recruit Count
- 30
- Registration Number
- NCT03910088
- Locations
- 🇪🇬
Cairo University, Cairo, Zamalek, Egypt
Palbociclib in Combination With Chemotherapy in Treating Children With Relapsed Acute Lymphoblastic Leukemia (ALL) or Lymphoblastic Lymphoma (LL)
- Conditions
- Interventions
- First Posted Date
- 2019-01-03
- Last Posted Date
- 2024-08-16
- Lead Sponsor
- Children's Oncology Group
- Target Recruit Count
- 12
- Registration Number
- NCT03792256
- Locations
- 🇺🇸
Children's Healthcare of Atlanta - Egleston, Atlanta, Georgia, United States
🇺🇸Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States
🇺🇸University of Minnesota/Masonic Cancer Center, Minneapolis, Minnesota, United States
Mitochondrial Function in Septic Patients
- First Posted Date
- 2018-11-21
- Last Posted Date
- 2020-01-27
- Lead Sponsor
- Chiang Mai University
- Target Recruit Count
- 20
- Registration Number
- NCT03748537
- Locations
- 🇹🇭
Emergency Department, Faculty of Medicine, Chaing Mai University, Chiang Mai, Thailand
Drug Development Updates
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