Tafenoquine
- Generic Name
- Tafenoquine
- Brand Names
- Arakoda, Krintafel
- Drug Type
- Small Molecule
- Chemical Formula
- C24H28F3N3O3
- CAS Number
- 106635-80-7
- Unique Ingredient Identifier
- 262P8GS9L9
- Background
Tafenoquine is an 8-aminoquinoline analogue of primaquine which varies only on the presence of a 5-phenoxy group. It was discovered by the scientists at the Walter Reed Army Institute of Research in 1978 as a substitute for primaquine that would be more effective against relapsing vivax malaria. Tafenoquine was further developed collaboratively between Glaxo...
- Indication
用于16岁及以上疟疾患者，根治(预防复发)由间日疟原虫(P.vivax)导致的疟疾。
- Associated Conditions
- Malaria caused by plasmodium vivax
- Associated Therapies
- -
An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older
- Conditions
- Interventions
- First Posted Date
- 2024-10-30
- Last Posted Date
- 2024-12-13
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 300
- Registration Number
- NCT06666491
- Locations
- 🇮🇳
GSK Investigational Site, Surat, India
Vivax Elimination With Tafenoquine (VET) Study
- Conditions
- Interventions
- First Posted Date
- 2024-08-28
- Last Posted Date
- 2024-12-02
- Lead Sponsor
- Shoklo Malaria Research Unit
- Target Recruit Count
- 1000
- Registration Number
- NCT06575647
- Locations
- 🇹🇭
Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak Province, Thailand
Expanded Use in Persistent (B. Microti) Babesiosis
- Conditions
- First Posted Date
- 2024-06-27
- Last Posted Date
- 2024-06-27
- Lead Sponsor
- 60 Degrees Pharmaceuticals LLC
- Registration Number
- NCT06478641
Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis
- First Posted Date
- 2024-01-17
- Last Posted Date
- 2024-06-20
- Lead Sponsor
- 60 Degrees Pharmaceuticals LLC
- Target Recruit Count
- 33
- Registration Number
- NCT06207370
- Locations
- 🇺🇸
Tufts Medical Center, Boston, Massachusetts, United States
A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria
- First Posted Date
- 2023-11-28
- Last Posted Date
- 2024-08-29
- Lead Sponsor
- Menzies School of Health Research
- Target Recruit Count
- 1090
- Registration Number
- NCT06148792
- Locations
- 🇪🇹
Arba Minch General Hospital, Arba Minch, Ethiopia
🇵🇬Dr Moses Laman and Dr Brioni Moore, Alexishafen, Papua New Guinea
🇮🇩Dr Rini Poespoprodjo, Timika, Indonesia
Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand
- First Posted Date
- 2023-03-03
- Last Posted Date
- 2023-10-26
- Lead Sponsor
- Dr. Prayuth Sudathip
- Target Recruit Count
- 187
- Registration Number
- NCT05753150
- Locations
- 🇹🇭
Malaria Clinic, Than To, Yala, Thailand
🇹🇭District Hospital, Than To, Yala, Thailand
Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in Peru
- Conditions
- Interventions
- First Posted Date
- 2022-05-04
- Last Posted Date
- 2023-12-05
- Lead Sponsor
- Medicines for Malaria Venture
- Target Recruit Count
- 40
- Registration Number
- NCT05361486
- Locations
- 🇵🇪
Nauta Nucleo- Base, Nauta, Loreto, Peru
Operational Feasibility of Appropriate Radical Cure of Plasmodium Vivax With Tafenoquine or Primaquine After Quantitative G6PD Testing in Brazil
- Conditions
- Interventions
- First Posted Date
- 2021-10-27
- Last Posted Date
- 2023-06-13
- Target Recruit Count
- 16000
- Registration Number
- NCT05096702
- Locations
- 🇧🇷
Grande Vitória, Manaus, AM, Brazil
🇧🇷Efigênio Salles (UBSR), Manaus, AM, Brazil
🇧🇷Cooperativa I, Manaus, AM, Brazil
Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali
- Conditions
- Interventions
- First Posted Date
- 2021-10-18
- Last Posted Date
- 2022-01-18
- Lead Sponsor
- London School of Hygiene and Tropical Medicine
- Target Recruit Count
- 80
- Registration Number
- NCT05081089
- Locations
- 🇲🇱
Malaria Research and Training Centre, Bamako, Mali
Tafenoquine and Primaquine in Colostrum and Breast Milk
- First Posted Date
- 2021-08-02
- Last Posted Date
- 2024-04-04
- Lead Sponsor
- University of Oxford
- Registration Number
- NCT04984759
- Locations
- 🇹🇭
Shoklo Malaria Research Unit (SMRU), Mae Sot, Tak, Thailand
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.