Fluticasone furoate
- Generic Name
- Fluticasone furoate
- Brand Names
- Arnuity Ellipta, Avamys, Breo Ellipta, Flonase Sensimist, Trelegy Ellipta, Veramyst
- Drug Type
- Small Molecule
- Chemical Formula
- C27H29F3O6S
- CAS Number
- 397864-44-7
- Unique Ingredient Identifier
- JS86977WNV
- Background
Fluticasone furoate is a synthetic glucocorticoid available as an inhaler and nasal spray for various inflammatory indications. Fluticasone furoate was first approved in 2007.
- Indication
Fluticasone furoate is indicated for once-daily maintenance (i.e. prophylactic) treatment of asthma in patients ≥5 years old. Fluticasone furoate is available in two combination medications - one in combination with vilanterol and one in combination with both vilanterol and umeclidinium- which are both indicated for the management of chronic obstructive pulmonary disease (COPD) and for the treatment of asthma in patients ≥18 years old for the vilanterol-umeclidinium-fluticasone product and ≥5 years old for the vilanterol-fluticasone product.
Fluticasone furoate is available over the counter as a nasal spray for the symptomatic treatment of hay fever and other upper respiratory allergies in patients ≥2 years old.
- Associated Conditions
- Asthma, Chronic Obstructive Pulmonary Disease (COPD), Perennial Allergy, Seasonal Allergies
Mechanism of Action of Fluticasone Furoate in Childhood Obstructive Sleep Apnea Syndrome
- Conditions
- Childhood Obstructive Sleep Apnea Syndrome (OSAS)
- Interventions
- First Posted Date
- 2008-01-28
- Last Posted Date
- 2015-05-04
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 24
- Registration Number
- NCT00603044
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
Intranasal Steroids and Oxymetazoline in Allergic Rhinitis
- Conditions
- Allergic Rhinitis
- Interventions
- Drug: Placebo Fluticasone furoate
- First Posted Date
- 2008-01-02
- Last Posted Date
- 2013-12-17
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 64
- Registration Number
- NCT00584987
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
Repeat Dose GW685698X With Magnesium Stearate, Excipient Bridging Study, In Healthy Volunteers
- First Posted Date
- 2007-08-30
- Last Posted Date
- 2017-08-04
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 36
- Registration Number
- NCT00522678
- Locations
- 🇦🇺
GSK Investigational Site, Melbourne, Victoria, Australia
Intranasal Steroids and the Nasal Ocular Response
- Conditions
- Seasonal Allergic Rhinitis
- First Posted Date
- 2007-05-16
- Last Posted Date
- 2013-06-03
- Lead Sponsor
- University of Chicago
- Target Recruit Count
- 20
- Registration Number
- NCT00473915
- Locations
- 🇺🇸
University of Chicago, Chicago, Illinois, United States
Single Dose GW685698X Magnesium Stearate Study In Asthmatic Patients.
- Conditions
- Asthma
- Interventions
- Drug: GW685698X containing magnesium stearate
- First Posted Date
- 2007-03-07
- Last Posted Date
- 2017-08-04
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT00444509
- Locations
- 🇳🇿
GSK Investigational Site, Wellington, New Zealand
Investigating The Pharmacokinetics Of An Inhaled Dose Of A New Corticosteroid In Patients With Impaired Liver Function
- First Posted Date
- 2007-01-08
- Last Posted Date
- 2017-11-06
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 20
- Registration Number
- NCT00419237
Study Of Perennial Allergic Rhinitis
- Conditions
- Rhinitis, Allergic, Seasonal
- First Posted Date
- 2006-07-31
- Last Posted Date
- 2018-08-31
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 65
- Registration Number
- NCT00358475
- Locations
GSK Investigational Site
Study In Adults And Adolescents With Seasonal Allergic Rhinitis.
- Conditions
- Rhinitis, Allergic, Seasonal
- First Posted Date
- 2005-09-26
- Last Posted Date
- 2016-09-15
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 288
- Registration Number
- NCT00225823
- Locations
- 🇸🇪
GSK Investigational Site, Ängelholm, Sweden
Long Term Safety Of GW685698X Via Nasal Biopsy
- Conditions
- Rhinitis, Allergic, Perennial
- Interventions
- First Posted Date
- 2005-09-23
- Last Posted Date
- 2016-10-28
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 125
- Registration Number
- NCT00224523
- Locations
- 🇳🇱
GSK Investigational Site, Nijmegen, Netherlands
Once-Daily Investigational Nasal Spray In Adults And Adolescents With Vasomotor Rhinitis
- Conditions
- Vasomotor RhinitisRhinitis, Vasomotor
- First Posted Date
- 2005-07-12
- Last Posted Date
- 2017-08-21
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 350
- Registration Number
- NCT00118703
- Locations
- 🇷🇴
GSK Investigational Site, Iasi, Romania
Drug Development Updates
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