Muromonab

概览

Muromonab is a monoclonal anti-CD3 antibody used as immunosuppressive therapy in kidney, heart, and liver transplant patients.

作用机制

Muromonab binds to the T-cell surface glycoprotein CD3 epsilon chain. It appears to kill CD-3 positive cells by inducing Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

适应症

For treatment of organ transplant recipients, prevention of organ rejection

• Acute Renal Allograft Rejection
• Steroid resistant Heart transplant rejection
• Steroid resistant hepatic transplant rejection