Brimonidine
- Generic Name
- Brimonidine
- Brand Names
- Alphagan, Combigan, Lumify, Mirvaso, Onreltea, Qoliana, Simbrinza
- Drug Type
- Small Molecule
- Chemical Formula
- C11H10BrN5
- CAS Number
- 59803-98-4
- Unique Ingredient Identifier
- E6GNX3HHTE
- Background
Brimonidine is an alpha-adrenergic agonist and 2-imidazoline derivative that was first introduced in 1996. It is considered to be a third generation alpha-2 aadrenergic receptor agonist, since it displays preferential binding at alpha-2 adrenoceptors over alpha-1 receptors. Brimonidine displays a higher selectivity toward the alpha-2 adrenergic receptors tha...
- Indication
Opthalmic
Indicated for lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension as monotherapy or combination product with brinzolamide.
Topical
Indicated for the treatment of persistent (non-transient) facial erythema of rosacea in adults 18 years of age or older.
- Associated Conditions
- Increased Intra Ocular Pressure (IOP), Ocular Hypertension, Facial erythema
- Associated Therapies
- -
INFLUENCE OF TOPICAL INDOMETHACIN ON HYPOTHENSIVE EFFECT OF BRIMONIDINE
- Conditions
- First Posted Date
- 2006-07-04
- Last Posted Date
- 2006-10-26
- Lead Sponsor
- Federal University of São Paulo
- Registration Number
- NCT00347035
Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise
- Conditions
- First Posted Date
- 2006-04-10
- Last Posted Date
- 2007-02-12
- Lead Sponsor
- Medical University of Vienna
- Target Recruit Count
- 18
- Registration Number
- NCT00312416
- Locations
- 🇦🇹
Department of Clinical Pharmacology, Vienna, Austria
Safety and Efficacy of Brimonidine in Patients With Glaucoma or Ocular Hypertension
- Conditions
- First Posted Date
- 2005-09-15
- Last Posted Date
- 2011-05-30
- Lead Sponsor
- Allergan
- Target Recruit Count
- 207
- Registration Number
- NCT00168363
Drug Development Updates
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