Overview
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
Associated Conditions
- Aspergillosis
- Blastomycosis
- Chromoblastomycosis
- Coccidioidal meningitis
- Esophageal Candidiasis
- Fungal Infections
- Fungal skin infection
- Histoplasmosis
- Onychomycosis
- Oropharyngeal Candidiasis
- Paracoccidioidomycosis
- Penicillium marneffei infection
- Pulmonary coccidioides
- Sporotrichosis
- Vulvovaginal Candidiasis
- Disseminated Other specified protozoal diseases
Clinical Trials
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Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2016/09/09 | Phase 4 | Terminated | Xian-Janssen Pharmaceutical Ltd. | ||
2016/08/30 | Phase 1 | Completed | |||
2016/08/23 | Phase 1 | Terminated | |||
2016/07/20 | Phase 1 | Completed | |||
2016/07/18 | Phase 1 | Completed | |||
2016/07/13 | Phase 1 | Completed | |||
2016/07/06 | Phase 1 | Completed | |||
2016/07/01 | Phase 1 | Completed | |||
2016/06/29 | Phase 1 | Completed | |||
2016/06/22 | Phase 1 | Completed |
FDA Drug Approvals
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Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
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Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
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Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
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Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||