Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
A Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibitor (Itraconazole) and Inducer (Rifampin) on the Drug Levels of Golcadomide (BMS-986369) in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2024-04-12
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Celgene
- Target Recruit Count
- 36
- Registration Number
- NCT06363630
- Locations
- 🇺🇸
Local Institution - 0002, Atlanta, Georgia, United States
🇺🇸Local Institution - 0001, Lenexa, Kansas, United States
A Study to Investigate the Pharmacokinetics of Baxdrostat When Given Alone and in Combination With Itraconazole in Healthy Participants
- First Posted Date
- 2024-04-10
- Last Posted Date
- 2024-07-03
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 14
- Registration Number
- NCT06357520
- Locations
- 🇺🇸
Research Site, Brooklyn, Maryland, United States
A Study to Learn About How Itraconazole and Carbamazepine Affect the Level of BAY2927088 in the Blood When These Drugs Are Taken Together by Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2024-04-05
- Last Posted Date
- 2024-06-20
- Lead Sponsor
- Bayer
- Target Recruit Count
- 30
- Registration Number
- NCT06348888
- Locations
- 🇺🇸
Parexel Baltimore - Early Phase Clinical Unit, Baltimore, Maryland, United States
Study to Evaluate the Drug-drug Interaction of JMKX001899 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2024-04-04
- Last Posted Date
- 2024-04-04
- Lead Sponsor
- Jemincare
- Target Recruit Count
- 72
- Registration Number
- NCT06348290
A Study to Assess LY4100511 (DC-853) in Healthy Adult Participants
- Conditions
- Interventions
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-05-10
- Target Recruit Count
- 50
- Registration Number
- NCT06345794
- Locations
- 🇺🇸
ICON San Antonio Clinical Research Unit, San Antonio, Texas, United States
A Study to Evaluate the Effect of Itraconazole and Rifampicin on the Pharmacokinetics of SY-5007 in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2024-03-27
- Last Posted Date
- 2024-03-27
- Lead Sponsor
- Shouyao Holdings (Beijing) Co. LTD
- Target Recruit Count
- 28
- Registration Number
- NCT06332053
- Locations
- 🇨🇳
West China Hospital of Sichuan University, Chengdu, Sichuan, China
Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of Sporotrichosis
- Conditions
- Interventions
- First Posted Date
- 2024-03-08
- Last Posted Date
- 2024-03-08
- Lead Sponsor
- First Hospital of China Medical University
- Target Recruit Count
- 150
- Registration Number
- NCT06300138
Studies Evaluating the Effects of Itraconazole or Rifampicin on the Pharmacokinetics of TY-9591 Tablets in Healthy Subjects
- First Posted Date
- 2024-02-13
- Last Posted Date
- 2024-02-26
- Lead Sponsor
- TYK Medicines, Inc
- Target Recruit Count
- 48
- Registration Number
- NCT06255951
- Locations
- 🇨🇳
Yali Liu, Guangdong, Shantou, China
Drug-Drug Interaction of ASN51 With Fluvoxamine, Itraconazole and Paroxetine in Healthy Subjects
- Conditions
- Interventions
- First Posted Date
- 2024-01-30
- Last Posted Date
- 2024-12-18
- Lead Sponsor
- Asceneuron S.A.
- Target Recruit Count
- 50
- Registration Number
- NCT06232109
- Locations
- 🇳🇱
ICON Groningen Van Swietenlaan 6, Groningen, Netherlands
Assessment of the Safety, Tolerability and Pharmacokinetics of AV078 in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2024-01-16
- Last Posted Date
- 2024-11-27
- Lead Sponsor
- Aeovian Pharmaceuticals, Inc.
- Target Recruit Count
- 136
- Registration Number
- NCT06205381
- Locations
- 🇦🇺
Q-Pharm, Herston, Queensland, Australia
🇦🇺Nucleus Network Pty Ltd, Melbourne, Victoria, Australia
Drug Development Updates
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