Carbamazepine
- Generic Name
- Carbamazepine
- Brand Names
- Carbatrol, Carnexiv, Epitol, Equetro, Tegretol
- Drug Type
- Small Molecule
- Chemical Formula
- C15H12N2O
- CAS Number
- 298-46-4
- Unique Ingredient Identifier
- 33CM23913M
- Background
Carbamazepine, also known as Tegretol, is an anticonvulsant drug and analgesic drug used to control seizures and to treat pain resulting from trigeminal neuralgia. It was initially approved by the FDA in 1965. Aside from the above uses, this drug is also given to control the symptoms of bipolar 1. Interestingly, carbamazepine was the first anticonvulsant used to treat individuals with bipolar disorder.
- Indication
Carbamazepine is indicated for the treatment of epilepsy and pain associated with true trigeminal neuralgia. In particular, carbamazepine has shown efficacy in treating mixed seizures, partial seizures with complex symptoms, and generalized tonic-clonic seizures. Carbamazepine is also indicated for the treatment of manic episodes and mixed manic-depressive episodes caused by bipolar I disorder. Some off-label, unapproved uses of carbamazepine include the treatment of alcohol withdrawal syndrome and restless leg syndrome.
- Associated Conditions
- Acute Mania, Alcohol Withdrawal Syndrome, Complex Partial Seizure Disorder, Generalized Tonic-Clonic Seizures, Mixed manic depressive episode, Pain, Partial Seizures With Secondary Generalization, Restless Legs Syndrome (RLS)
Drug-Drug Interaction Potential of Mavorixafor
- Conditions
- Healthy Participants
- Interventions
- First Posted Date
- 2025-04-06
- Last Posted Date
- 2025-04-06
- Lead Sponsor
- X4 Pharmaceuticals
- Target Recruit Count
- 36
- Registration Number
- NCT06914869
- Locations
- 🇺🇸
Parexel International LLC, Baltimore, Maryland, United States
A Study of Carbamazepine (CBZ) and MK-8527 in Healthy Adult Participants (MK-8527-012)
- First Posted Date
- 2025-03-25
- Last Posted Date
- 2025-05-08
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 16
- Registration Number
- NCT06893081
- Locations
- 🇺🇸
Celerion ( Site 0001), Tempe, Arizona, United States
Comparison of Oxcarbazepine Versus Carbamazepine in the Management of Trigeminal Neuralgia
- Conditions
- Trigeminal Neuralgia
- Interventions
- First Posted Date
- 2025-02-27
- Last Posted Date
- 2025-03-04
- Lead Sponsor
- Jinnah Postgraduate Medical Centre
- Target Recruit Count
- 122
- Registration Number
- NCT06849219
- Locations
- 🇵🇰
Jinnah Postgraduate Medical Centre, Karachi, Sindh, Pakistan
A Drug-Drug Interaction Study to Evaluate the Effects of Itraconazole, Carbamazepine, Quinidine and Fluconazole on the Pharmacokinetics and Safety of EDP-323.
- Conditions
- RSV InfectionDrug Drug Interaction (DDI)
- Interventions
- First Posted Date
- 2025-02-26
- Last Posted Date
- 2025-02-26
- Lead Sponsor
- Enanta Pharmaceuticals, Inc
- Target Recruit Count
- 48
- Registration Number
- NCT06847464
- Locations
- 🇺🇸
ICON, plc, San Antonio, Texas, United States
A Drug-drug Interaction Study of S-892216 Coadministered With Carbamazepime to Healthy Adult Participants
- First Posted Date
- 2024-12-27
- Last Posted Date
- 2025-03-11
- Lead Sponsor
- Shionogi
- Target Recruit Count
- 16
- Registration Number
- NCT06751017
- Locations
- 🇺🇸
ICON Lenexa, Lenexa, Kansas, United States
A Multi-part Study of ALG-000184 to Evaluate Safety, Tolerability, Pharmacokinetics and Drug-drug Interaction Potential After Single and Multiple Doses in Healthy Volunteers
- Conditions
- Healthy Volunteer
- Interventions
- First Posted Date
- 2024-11-04
- Last Posted Date
- 2025-02-03
- Lead Sponsor
- Aligos Therapeutics
- Target Recruit Count
- 24
- Registration Number
- NCT06672900
- Locations
- 🇺🇸
PPD Austin Research Unit, Austin, Texas, United States
An Open-label Study in Healthy Participants to Evaluate AZD0780 as an Object or Precipitant of CYP3A4-mediated Drug-drug Interactions
- Conditions
- Dyslipidaemia
- Interventions
- Drug: Ethinyl estradiol/levonorgestrel
- First Posted Date
- 2024-11-04
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- AstraZeneca
- Target Recruit Count
- 59
- Registration Number
- NCT06671405
- Locations
- 🇺🇸
Research Site, Brooklyn, Maryland, United States
A Study to Learn If the Study Medicine Called Carbamazepine Changes How the Body Processes the Other Study Medicine Ibuzatrelvir in Healthy Adults
- First Posted Date
- 2024-10-17
- Last Posted Date
- 2025-02-03
- Lead Sponsor
- Pfizer
- Target Recruit Count
- 12
- Registration Number
- NCT06646042
- Locations
- 🇺🇸
Pfizer Clinical Research Unit - New Haven, New Haven, Connecticut, United States
A Drug-Drug Interaction Study of Carbamazepine and Opevesostat (MK-5684) in Healthy Adult Male Participants (MK-5684-012)
- Conditions
- Healthy
- Interventions
- First Posted Date
- 2024-10-09
- Last Posted Date
- 2025-04-17
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 14
- Registration Number
- NCT06633419
- Locations
- 🇺🇸
Celerion ( Site 0001), Tempe, Arizona, United States
Drug-Drug Interaction Study of Bomedemstat and Carbamazepine in Healthy Adult Participants (MK-3543-020)
- First Posted Date
- 2024-09-19
- Last Posted Date
- 2025-03-18
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 16
- Registration Number
- NCT06596668
- Locations
- 🇺🇸
Celerion, Inc. ( Site 0001), Tempe, Arizona, United States
Drug Development Updates
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