Oxcarbazepine

Generic Name: Oxcarbazepine

Brand Names: Oxtellar, Trileptal

Drug Type: Small Molecule

Chemical Formula: C_₁₅H_₁₂N_₂O_₂

CAS Number: 28721-07-5

Unique Ingredient Identifier: VZI5B1W380

Background: Oxcarbazepine is an anti-epileptic medication used in the treatment of partial onset seizures that was first approved for use in the United States in 2000. It is a structural derivative of carbamazepine and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood - a pro-drug of the more active...

Indication: In the United States, oxcarbazepine is indicated for use as monotherapy or adjunctive therapy in the treatment of partial-onset seizures in adults and as monotherapy in the treatment of partial-onset seizures in pediatric patients aged 4 years and above, and as adjunctive therapy in pediatric patients aged 2 years and above with partial-onset seizures.
...

Associated Conditions: Partial-Onset Seizures

Associated Therapies: Monotherapy

Clinical Trials

The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children

Phase 4

Recruiting

Conditions: Drug Resistant Epilepsy

Interventions: Drug: Valproic acid
Drug: Lamotrigine
Drug: Carbamazepin
Drug: Clobazam
Drug: Phenytoin
Drug: Oxcarbazepine

First Posted Date: 2023-01-26

Last Posted Date: 2023-01-26

Lead Sponsor: Dr Cipto Mangunkusumo General Hospital

Target Recruit Count: 100

Registration Number: NCT05697614

Locations: 🇮🇩
Cipto Mangunkusumo Hospital, Jakarta Pusat, Jakarta, Indonesia
🇮🇩
Harapan Kita Hospital, Jakarta, Indonesia
🇮🇩
Fatmawati Hospital, Jakarta, Indonesia

Comparision Efficacy of Carbamazepine & Oxcarbazepine in the Treatment of Trigeminal Neuralgia- a Randomised Clinical Trial

Phase 4

Conditions: Trigeminal Neuralgia

Interventions: Drug: Carbamazepine
Drug: Oxcarbazepine

First Posted Date: 2021-08-09

Last Posted Date: 2021-10-15

Lead Sponsor: Postgraduate Institute of Dental Sciences Rohtak

Target Recruit Count: 132

Registration Number: NCT04996199

Locations: 🇮🇳
PGIDS, Rohtak, Haryana, India
🇮🇳
Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India

A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil

Phase 1

Completed

Conditions: Epilepsy

Interventions: Drug: Padsevonil
Drug: Levetiracetam
Drug: Oxcarbazepine
Drug: Lamotrigine
Drug: Brivaracetam

First Posted Date: 2018-10-03

Last Posted Date: 2020-06-04

Lead Sponsor: UCB Biopharma S.P.R.L.

Target Recruit Count: 31

Registration Number: NCT03695094

Locations: 🇳🇱
Up0070 401, Leiden, Netherlands
🇧🇬
Up0070 101, Sofia, Bulgaria

Population Pharmacokinetics of Antiepileptic in Pediatrics

First Posted Date: 2017-06-22

Last Posted Date: 2024-10-30

Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Target Recruit Count: 1000

Registration Number: NCT03196466

Locations: 🇫🇷
AP-HP Cochin, Paris, France

Longitudinal Comparative Effectiveness of Bipolar Disorder Therapies

Terminated

Conditions: Bipolar Disorder

First Posted Date: 2016-09-08

Last Posted Date: 2024-03-12

Lead Sponsor: University of New Mexico

Target Recruit Count: 1037352

Registration Number: NCT02893371

Locations: 🇺🇸
Christophe G Lambert, Albuquerque, New Mexico, United States

Effect of Carbamazepine and Oxcarbazepine on Serum Neuron-specific Enolase and S100B in Focal Seizures

Phase 4

Completed

Conditions: Seizures, Focal

Interventions: Drug: Oxcarbazepine
Drug: Carbamazepine

First Posted Date: 2016-03-11

Last Posted Date: 2017-09-19

Lead Sponsor: All India Institute of Medical Sciences, Bhubaneswar

Target Recruit Count: 90

Registration Number: NCT02705768

Locations: 🇮🇳
AIIMS, Bhubaneswar, Bhubaneswar, Odisha, India

Effect of Oxcarbazepine on Serum Brain Derived Neurotrophic Factor (BDNF) in Bipolar Disorder

Phase 4

Completed

Conditions: Bipolar Disorder

Interventions: Drug: Oxcarbazepine

First Posted Date: 2015-05-29

Last Posted Date: 2019-05-07

Lead Sponsor: All India Institute of Medical Sciences, Bhubaneswar

Target Recruit Count: 50

Registration Number: NCT02456896

Locations: 🇮🇳
All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, India

Pharmacovigilance in Gerontopsychiatric Patients

Phase 3

Terminated

Conditions: Dementia
Depression
Schizophrenia
Psychosomatic Disorders
Anxiety Disorders

Interventions: Drug: Phenobarbital
Drug: Phenytoin
Drug: Carbamazepine
Drug: Oxcarbazepine
Drug: Valproic Acid
Drug: Lamotrigine
Drug: Topiramate
Drug: Gabapentin
Drug: Levetiracetam
Drug: Pregabalin
Drug: Lacosamide
Drug: Clonazepam
Drug: Biperiden
Drug: Levomepromazine
Drug: Fluphenazine
Drug: Perphenazine
Drug: Perazine
Drug: Thioridazine
Drug: Haloperidol
Drug: Melperone
Drug: Pipamperone
Drug: Bromperidol
Drug: Benperidol
Drug: Sertindole
Drug: Ziprasidone
Drug: Flupentixol
Drug: Chlorprothixene
Drug: Zuclopenthixol
Drug: Fluspirilene
Drug: Pimozide
Drug: Clozapine
Drug: Olanzapine
Drug: Quetiapine
Drug: Sulpiride
Drug: Tiapride
Drug: Amisulpride
Drug: Prothipendyl
Drug: Risperidone
Drug: Aripiprazole
Drug: Paliperidone
Drug: Diazepam
Drug: Oxazepam
Drug: Lorazepam
Drug: Bromazepam
Drug: Clobazam
Drug: Alprazolam
Drug: Hydroxyzine
Drug: Buspirone
Drug: Chloral Hydrate
Drug: Flurazepam
Drug: Nitrazepam
Drug: Triazolam
Drug: Lormetazepam
Drug: Temazepam
Drug: Midazolam
Drug: Brotizolam
Drug: Zopiclone
Drug: Zolpidem
Drug: Zaleplon
Drug: Melatonin
Drug: Clomethiazole
Drug: Diphenhydramine
Drug: Promethazine
Drug: Imipramine
Drug: Clomipramine
Drug: Opipramol
Drug: Trimipramine
Drug: Amitriptyline
Drug: Nortriptyline
Drug: Doxepin
Drug: Maprotiline
Drug: Amitriptyline oxide
Drug: Fluoxetine
Drug: Citalopram
Drug: Paroxetine
Drug: Sertraline
Drug: Fluvoxamine
Drug: Escitalopram
Drug: Tranylcypromine
Drug: Moclobemide
Drug: Mianserin
Drug: Trazodone
Drug: Mirtazapine
Drug: Bupropion
Drug: Venlafaxine
Drug: Reboxetine
Drug: Duloxetine
Drug: Agomelatine
Drug: Pyritinol
Drug: Piracetam
Drug: Donepezil
Drug: Rivastigmine
Drug: Galantamine
Drug: Memantine
Drug: Nicergoline
Drug: Acamprosate
Drug: Lithium

First Posted Date: 2015-03-02

Last Posted Date: 2018-02-28

Lead Sponsor: Hannover Medical School

Target Recruit Count: 407

Registration Number: NCT02374567

Locations: 🇩🇪
Bezirkskrankenhaus Augsburg, Augsburg, Germany
🇩🇪
Krankenhaus Hedwigshöhe, Berlin, Germany
🇩🇪
Hannover Medical School, Hannover, Germany

and more 2 locations

Gabapentin and Oxcarbazepine for Chronic Neuropathic Pain in Children and Adolescents: A Clinical Effectiveness Study

Phase 3

Not yet recruiting

Conditions: Pediatric Chronic Neuropathic Pain

Interventions: Drug: Gabapentin
Drug: Oxcarbazepine
Other: Placebo

First Posted Date: 2014-08-18

Last Posted Date: 2024-08-16

Lead Sponsor: Boston Children's Hospital

Target Recruit Count: 60

Registration Number: NCT02219373

Locations: 🇺🇸
Boston Children's Hospital, Boston, Massachusetts, United States

Protective Role of Oxcarbazepine in Multiple Sclerosis

Phase 2

Completed

Conditions: Multiple Sclerosis

Interventions: Drug: Placebo
Drug: Oxcarbazepine

First Posted Date: 2014-04-04

Last Posted Date: 2018-04-18

Lead Sponsor: Queen Mary University of London

Target Recruit Count: 30

Registration Number: NCT02104661

Locations: 🇬🇧
Barts Health NHS Trust, London, United Kingdom

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