Padsevonil
- Generic Name
- Padsevonil
- Drug Type
- Small Molecule
- Chemical Formula
- C14H14ClF5N4O2S
- CAS Number
- 1294000-61-5
- Unique Ingredient Identifier
- 0R1HN52K0N
- Background
Padsevonil is under investigation in clinical trial NCT03695094 (A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil).
A Study to Test the Blood Concentration of 4 Padsevonil Product Variants and the Effect of Food on Padsevonil
Phase 1
Withdrawn
- Conditions
- Healthy ParticipantsEpilepsy
- Interventions
- First Posted Date
- 2020-02-25
- Last Posted Date
- 2020-06-22
- Lead Sponsor
- UCB Biopharma SRL
- Registration Number
- NCT04283136
A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function
Phase 1
Terminated
- Conditions
- Healthy Study ParticipantsImpaired Hepatic Function
- Interventions
- First Posted Date
- 2019-10-23
- Last Posted Date
- 2021-07-28
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 12
- Registration Number
- NCT04136444
- Locations
- 🇺🇸
Up0056 004, Orlando, Florida, United States
A Study to Test the Interaction of Padsevonil With Oral Contraceptives in Healthy Female Participants
Phase 1
Terminated
- Conditions
- Healthy Female Participants
- Interventions
- Drug: Microgynon 30®
- First Posted Date
- 2019-10-18
- Last Posted Date
- 2021-06-24
- Lead Sponsor
- UCB Biopharma SRL
- Target Recruit Count
- 14
- Registration Number
- NCT04131517
- Locations
- 🇬🇧
Up0035 001, London, United Kingdom
A Study to Test the Cardiac Effects of Padsevonil in Healthy Study Participants
Phase 1
Terminated
- Conditions
- Healthy Study Participants
- Interventions
- First Posted Date
- 2019-10-15
- Last Posted Date
- 2021-06-18
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 54
- Registration Number
- NCT04126343
- Locations
- 🇬🇧
Up0050 001, London, United Kingdom
A Study to Test the Safety, and Tolerability of Padsevonil in Healthy Male Japanese Study Participants
- First Posted Date
- 2019-08-30
- Last Posted Date
- 2021-07-08
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 39
- Registration Number
- NCT04075409
- Locations
- 🇯🇵
Up0083 001, Tokyo, Japan
A Study to Test the Pharmacodynamic, Pharmacokinetic, Safety, and Tolerability of Padsevonil in Healthy Study Participants Receiving Either Ethanol or Cannabidiol
- First Posted Date
- 2019-07-31
- Last Posted Date
- 2021-06-18
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 40
- Registration Number
- NCT04039919
- Locations
- 🇳🇱
Up0071 001, Leiden, Netherlands
A Study to Test the Safety and Tolerability of Single and Multiple Doses of Padsevonil in Adult and Elderly Study Participants
Phase 1
Completed
- Conditions
- Elderly Study ParticipantsAdult Study Participants
- Interventions
- First Posted Date
- 2019-07-09
- Last Posted Date
- 2021-06-30
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 28
- Registration Number
- NCT04013191
- Locations
- 🇺🇸
Up0053 001, San Antonio, Texas, United States
A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy
Phase 3
Terminated
- Conditions
- Drug-Resistant EpilepsyFocal-Onset Seizures
- Interventions
- Drug: Placebo
- First Posted Date
- 2018-11-14
- Last Posted Date
- 2022-12-21
- Lead Sponsor
- UCB Biopharma SRL
- Target Recruit Count
- 232
- Registration Number
- NCT03739840
- Locations
- 🇧🇬
Ep0092 150, Blagoevgrad, Bulgaria
🇭🇷Ep0092 128, Zagreb, Croatia
🇪🇪Ep0092 276, Tallinn, Estonia
A Study in Participants With Epilepsy, to Evaluate the Pharmacokinetics, Safety and Tolerability of Oxcarbazepine on Padsevonil
Phase 1
Completed
- Conditions
- Epilepsy
- Interventions
- First Posted Date
- 2018-10-03
- Last Posted Date
- 2020-06-04
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 31
- Registration Number
- NCT03695094
- Locations
- 🇳🇱
Up0070 401, Leiden, Netherlands
🇧🇬Up0070 101, Sofia, Bulgaria
Study to Evaluate the Effect of Coadministered Erythromycin on the Pharmacokinetics and Safety of Padsevonil
- First Posted Date
- 2018-03-29
- Last Posted Date
- 2021-07-12
- Lead Sponsor
- UCB Biopharma S.P.R.L.
- Target Recruit Count
- 28
- Registration Number
- NCT03480243
- Locations
- 🇬🇧
Up0057 001, London, United Kingdom
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