Itraconazole
- Generic Name
- Itraconazole
- Brand Names
- Sporanox, Tolsura
- Drug Type
- Small Molecule
- Chemical Formula
- C35H38Cl2N8O4
- CAS Number
- 84625-61-6
- Unique Ingredient Identifier
- 304NUG5GF4
- Background
One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.
- Indication
For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.
- Associated Conditions
- Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
- Associated Therapies
- -
Randomized, Controlled, Double-Blind Study of Itraconazole Oral Solution Versus Fluconazole Tablets for the Treatment of Esophageal Candidiasis.
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen Pharmaceuticals
- Registration Number
- NCT00002132
- Locations
- 🇺🇸
Rush Presbyterian - Saint Luke's Med Ctr, Chicago, Illinois, United States
🇺🇸Univ of Missouri at Kansas City School of Medicine, Kansas City, Missouri, United States
🇺🇸Dr Eskild A Petersen, Tucson, Arizona, United States
A Study of Treatments for Fungal Infections of the Mouth and Throat in HIV-Infected Patients Who Have Had Success With Itraconazole But Not With Fluconazole
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen, LP
- Registration Number
- NCT00002341
- Locations
- 🇺🇸
Buckley Braffman Stern Med Associates, Philadelphia, Pennsylvania, United States
Study of Itraconazole in Patients With Advanced HIV Infection
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen, LP
- Target Recruit Count
- 36
- Registration Number
- NCT00002370
- Locations
- 🇺🇸
Erie County Med Ctr / Pharmacy D, Buffalo, New York, United States
A Study of Itraconazole in the Prevention of Histoplasmosis, a Fungal Infection, in HIV-Infected Patients
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen, LP
- Registration Number
- NCT00002438
- Locations
- 🇺🇸
Infectious Diseases Research Clinic / Indiana Univ Hosp, Indianapolis, Indiana, United States
🇺🇸Infectious Diseases of Indianapolis, Indianapolis, Indiana, United States
🇺🇸Infectious Diseases Association / Research Med Ctr, Kansas City, Missouri, United States
An Open Study of the Effect of Itraconazole Oral Solution for the Treatment of Fluconazole Refractory Oropharyngeal Candidiasis in HIV-Positive Subjects.
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen, LP
- Registration Number
- NCT00002133
- Locations
- 🇺🇸
Pennsylvania Hosp, Philadelphia, Pennsylvania, United States
🇺🇸Infectious Disease Clinic, Nashville, Tennessee, United States
🇺🇸Ohio State Univ Hosp, Columbus, Ohio, United States
A Randomized, Open, Comparative Multicenter Study of Initial Treatment With Intravenous Itraconazole Versus Amphotericin B Followed by Consolidation Treatment With Itraconazole Capsules in Patients With Blastomycosis or Histoplasmosis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2005-06-24
- Lead Sponsor
- Janssen, LP
- Target Recruit Count
- 60
- Registration Number
- NCT00002159
- Locations
- 🇺🇸
Community Hosp, Indianapolis, Indiana, United States
🇺🇸LSU Med Ctr / Div of Pulmonary & Critical Care Med, Shreveport, Louisiana, United States
🇺🇸Univ of Arkansas for Med Sciences, Little Rock, Arkansas, United States
A Study of Itraconazole in the Treatment and Prevention of Histoplasmosis, a Fungal Infection, in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-04
- Target Recruit Count
- 30
- Registration Number
- NCT00000975
- Locations
- 🇺🇸
USC CRS, Los Angeles, California, United States
🇺🇸Northwestern University CRS, Chicago, Illinois, United States
🇺🇸Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States
A Study of Itraconazole in Preventing the Return of Histoplasmosis, a Fungal Infection, in Patients With AIDS
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 30
- Registration Number
- NCT00000992
- Locations
- 🇺🇸
Indiana Univ. School of Medicine, Infectious Disease Research Clinic, Indianapolis, Indiana, United States
🇺🇸Univ. of Cincinnati CRS, Cincinnati, Ohio, United States
🇺🇸Washington U CRS, Saint Louis, Missouri, United States
Safety and Antifungal Activity of Recombinant Interferon-Gamma 1b (rIFN-Gamma 1b) Given With Standard Therapy in Patients With Cryptococcal Meningitis
- Conditions
- First Posted Date
- 2001-08-31
- Last Posted Date
- 2009-06-03
- Lead Sponsor
- InterMune
- Target Recruit Count
- 60
- Registration Number
- NCT00012467
- Locations
- 🇺🇸
Houston Veterans Administration Med Ctr, Houston, Texas, United States
🇺🇸Univ of Texas / Med School at Houston, Houston, Texas, United States
🇵🇪Instituto de Medicina Tropical, Lima, Peru
Phase I/II Study of Itraconazole for Blastomycosis, Histoplasmosis, and Sporotrichosis
- Conditions
- First Posted Date
- 2000-02-25
- Last Posted Date
- 2006-06-09
- Lead Sponsor
- National Center for Research Resources (NCRR)
- Target Recruit Count
- 7
- Registration Number
- NCT00004811
Drug Development Updates
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