Itraconazole

Generic Name
Itraconazole
Brand Names
Sporanox, Tolsura
Drug Type
Small Molecule
Chemical Formula
C35H38Cl2N8O4
CAS Number
84625-61-6
Unique Ingredient Identifier
304NUG5GF4
Background

One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis & aspergillosis.

Indication

For the treatment of the following fungal infections in immunocompromised and non-immunocompromised patients: pulmonary and extrapulmonary blastomycosis, histoplasmosis, aspergillosis, and onychomycosis.

Associated Conditions
Aspergillosis, Blastomycosis, Chromoblastomycosis, Coccidioidal meningitis, Esophageal Candidiasis, Fungal Infections, Fungal skin infection, Histoplasmosis, Onychomycosis, Oropharyngeal Candidiasis, Paracoccidioidomycosis, Penicillium marneffei infection, Pulmonary coccidioides, Sporotrichosis, Vulvovaginal Candidiasis, Disseminated Other specified protozoal diseases
Associated Therapies
-

A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants

First Posted Date
2021-12-17
Last Posted Date
2022-08-10
Lead Sponsor
Bristol-Myers Squibb
Target Recruit Count
30
Registration Number
NCT05162222
Locations
🇺🇸

Covance Clinical Research Unit - Dallas, Dallas, Texas, United States

A Drug-Drug Interaction Study to Evaluate the Effect of Itraconazole on the Pharmacokinetic Profile of Etrumadenant in Healthy Adult Participants

Phase 1
Completed
Conditions
Interventions
First Posted Date
2021-12-10
Last Posted Date
2024-05-24
Lead Sponsor
Arcus Biosciences, Inc.
Target Recruit Count
20
Registration Number
NCT05154136
Locations
🇺🇸

Celerion, Lincoln, Nebraska, United States

A Phase 1/2a Study of DB-1303/BNT323 in Advanced/Metastatic Solid Tumors

First Posted Date
2021-12-09
Last Posted Date
2024-10-03
Lead Sponsor
DualityBio Inc.
Target Recruit Count
766
Registration Number
NCT05150691
Locations
🇺🇸

Kapi'olani Medical Center for Women and Children, Honolulu, Hawaii, United States

🇺🇸

Women's Cancer Care, Covington, Louisiana, United States

🇺🇸

Holy Cross Hospital, Silver Spring, Maryland, United States

and more 75 locations

Study of the Effects of Itraconazole and Rifampin on LOXO-305 in Healthy Participants

First Posted Date
2021-11-24
Last Posted Date
2021-11-24
Lead Sponsor
Loxo Oncology, Inc.
Target Recruit Count
24
Registration Number
NCT05134337
Locations
🇺🇸

Covance Clinical Research Unit, Daytona Beach, Florida, United States

A Prospective Study on Optimizing Treatment for ABPA

First Posted Date
2021-11-22
Last Posted Date
2021-11-22
Lead Sponsor
Shanghai Zhongshan Hospital
Target Recruit Count
100
Registration Number
NCT05129033

Drug-drug Interaction Study of Ganaplacide and Lumefantrine With Itraconazole

First Posted Date
2021-10-20
Last Posted Date
2022-10-28
Lead Sponsor
Novartis Pharmaceuticals
Target Recruit Count
19
Registration Number
NCT05084651
Locations
🇬🇧

Novartis Investigative Site, Belfast, Northern Ireland, United Kingdom

A Study to Investigate the Drug-drug Interactions (DDIs) of SKLB1028 With Itraconazole, Gemfibrozil or Rifampicin in Healthy Subjects

First Posted Date
2021-10-06
Last Posted Date
2021-10-06
Lead Sponsor
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Target Recruit Count
42
Registration Number
NCT05069870
Locations
🇨🇳

Beijing Friendship Hospital, Capital Medical University, Beijing, China

A Study of Soticlestat With Itraconazole and Mefenamic Acid in Healthy Adults

First Posted Date
2021-10-01
Last Posted Date
2023-10-03
Lead Sponsor
Takeda
Target Recruit Count
28
Registration Number
NCT05064449
Locations
🇺🇸

Celerion, Lincoln, Nebraska, United States

A Study to Evaluate Drug-Drug Interaction of Larotinib With Itraconazole and Rifampin in Healthy Adult Participants

Phase 1
Active, not recruiting
Conditions
Interventions
First Posted Date
2021-09-27
Last Posted Date
2022-10-27
Lead Sponsor
Sunshine Lake Pharma Co., Ltd.
Target Recruit Count
32
Registration Number
NCT05057949
Locations
🇨🇳

First Hospital of Jilin University, Changchun, Jilin, China

A Study to Evaluate the Effect of Multiple Doses of Itraconazole, Phenytoin, and Paroxetine on the Single-Dose Pharmacokinetics of Poziotinib in Healthy Adult Participants

First Posted Date
2021-07-29
Last Posted Date
2021-09-05
Lead Sponsor
Spectrum Pharmaceuticals, Inc
Target Recruit Count
74
Registration Number
NCT04981704
Locations
🇺🇸

Celerion, Phoenix clinical facility, Tempe, Arizona, United States

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