Glyburide

Generic Name: Glyburide

Brand Names: Diabeta, Glucovance, Glynase, Amglidia

Drug Type: Small Molecule

Chemical Formula: C_₂₃H_₂₈ClN_₃O_₅S

CAS Number: 10238-21-8

Unique Ingredient Identifier: SX6K58TVWC

Background: Glyburide is a second generation sulfonylurea used to treat patients with diabetes mellitus type II. It is typically given to patients who cannot be managed with the standard first line therapy, metformin. Glyburide stimulates insulin secretion through the closure of ATP-sensitive potassium channels on beta cells, raising intracellular potassium and calcium ion concentrations.

Glyburide was granted FDA approval on 1 May 1984. A formulation with metformin was granted FDA approval on on 31 July 2000.

Indication: Glyburide is indicated alone or as part of combination product with metformin, as an adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus.

Associated Conditions: Gestational Diabetes Mellitus (GDM), Glycemic Control, Type 2 Diabetes Mellitus

Clinical Trials

Oral Antidiabetic Agents in Pregnancy

Phase 4

Conditions: Gestational Diabetes

Interventions: Drug: Metformin
Drug: Glyburide

First Posted Date: 2014-03-19

Last Posted Date: 2014-03-19

Lead Sponsor: Hospital de Clinicas de Porto Alegre

Target Recruit Count: 80

Registration Number: NCT02091336

Locations: 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil

A Feasibility Study Looking at the Use of Glibenclamide and metfoRmin Versus stAndard Care in gEstational diabeteS

Phase 3

Completed

Conditions: Pregnancy
Gestational Diabetes

Interventions: Drug: Glibenclamide
Drug: Insulin

First Posted Date: 2014-03-06

Last Posted Date: 2016-12-08

Lead Sponsor: University of Edinburgh

Target Recruit Count: 23

Registration Number: NCT02080377

Locations: 🇬🇧
St Johns Hospital, Livingston, West Lothian, United Kingdom
🇬🇧
Princess Royal Infirmary, Glasgow, Lanarkshire, United Kingdom
🇬🇧
Western General Hospital, Edinburgh, Lothian, United Kingdom

and more 2 locations

Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. Systematic Review

Completed

Conditions: Gestational Diabetes Mellitus

Interventions: Drug: Metformin vs Glyburide trials
Drug: Glyburide vs Insulin trials
Drug: Metformin vs Insulin trials

First Posted Date: 2013-11-28

Last Posted Date: 2015-03-24

Lead Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Target Recruit Count: 2509

Registration Number: NCT01998113

Locations: 🇪🇸
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain

Glycemic Profile in Women With Gestational Diabetes Treated With Glyburide

Phase 4

Withdrawn

Conditions: Gestational Diabetes

Interventions: Drug: Glyburide
Device: Continuous glucose monitor

First Posted Date: 2013-09-20

Last Posted Date: 2016-05-11

Lead Sponsor: University of Pittsburgh

Registration Number: NCT01947699

Locations: 🇺🇸
Magee Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States

Effect of Vildagliptin vs. Glibenclamide on Circulating Endothelial Progenitor Cell Number Type 2 Diabetes

Phase 3

Completed

Conditions: Type 2 Diabetes

Interventions: Drug: Vildagliptin
Drug: Glibenclamide
Drug: Metformin

First Posted Date: 2013-04-02

Last Posted Date: 2017-08-02

Lead Sponsor: Azienda Ospedaliero-Universitaria di Parma

Target Recruit Count: 64

Registration Number: NCT01822548

Locations: 🇮🇹
Azienda Opedaliera-Universitaria, Parma, Italy
🇮🇹
Azienda Ospedaliera-Universitaria, Parma, Italy

Glyburide Advantage in Malignant Edema and Stroke - Remedy Pharmaceuticals

Phase 2

Completed

Conditions: Ischemic Stroke
Malignant Edema

Interventions: Drug: Placebo
Drug: Glyburide for Injection

First Posted Date: 2013-02-18

Last Posted Date: 2024-11-12

Lead Sponsor: Remedy Pharmaceuticals, Inc.

Target Recruit Count: 86

Registration Number: NCT01794182

Locations: 🇺🇸
University of Maryland School of Medicine, Baltimore, Maryland, United States
🇺🇸
UPMC Presbyterian Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States

and more 14 locations